Hormonal treatment and quality of life of prostate cancer patients: new evidence

Tucci, Marco; Leone, Gianmarco; Buttigliero, Consuelo; Zichi, Clizia; Stefano, Rosario Francesco Di; Pignataro, Daniele; Vignani, Francesca; Scagliotti, Giorgio Vittorio; Maïo, Massimo Di

doi:10.23736/s0393-2249.17.03066-1

Cited by 38 publications

(30 citation statements)

References 15 publications

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“…Many patients that receive Intensity-Modulated Radiation Therapy or Volumetric-Modulated Arc Therapy for PC experience acute GU toxicities and acute GI toxicities (46.4-47.1%) [5] . Toxicities may also occur due to concurrent hormone therapy, including vasomotor flushing, loss of libido, erectile dysfunction, fatigue, reduced cognition and mood impairment, poor quality of sleep, gynecomastia, and anemia [6] .…”

Section: Introductionmentioning

confidence: 99%

An observational study evaluating the impact on prostate patient outcomes and experiences when radiation therapists use a standard grading system tool to assess and document treatment-related toxicities and interventions

Leung

Fineberg

Larsen

et al. 2022

Journal of Medical Imaging and Radiation Sciences

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Section: Introductionmentioning

confidence: 99%

An observational study evaluating the impact on prostate patient outcomes and experiences when radiation therapists use a standard grading system tool to assess and document treatment-related toxicities and interventions

Leung

Fineberg

Larsen

et al. 2022

Journal of Medical Imaging and Radiation Sciences

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“…Unfortunately, ADT can have several detrimental side effects including; increases in fat mass, low bone mineral density, loss of muscle mass and reduced muscle strength [ 8 – 10 ]. These side effects can lead to significant reductions in physical performance of everyday activities [ 8 , 11 ] and reduced quality of life [ 12 ], and they can increase the risk of cardiovascular diseases, diabetes, fractures [ 5 , 8 , 9 ] and depression [ 8 , 13 , 14 ]. The management of these considerable negative effects is an essential part of the supportive cancer care for men receiving ADT [ 9 , 12 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Supervised exercise therapy compared with no exercise therapy to reverse debilitating effects of androgen deprivation therapy in patients with prostate cancer: a systematic review and meta-analysis

Ussing

Mikkelsen

Villumsen

et al. 2021

Prostate Cancer Prostatic Dis

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Background Androgen deprivation therapy (ADT) in patients with prostate cancer can have several debilitating side effects. Supervised exercise is recommended to ameliorate these negative effects. Objective To systematically evaluate the effect of supervised exercise therapy compared to no exercise therapy in patients with prostate cancer undergoing ADT, primarily according to the patient critical outcomes, ‘disease-specific quality of life’ and ‘walking performance’ measured at end of treatment. Methods We searched PubMed/Medline, Embase, Cochrane Library, Cinahl and Pedro, to identify randomised controlled trials (RCTs), which investigated the effect of supervised exercise therapy compared to no exercise therapy in patients with prostate cancer receiving ADT, last search: June 2021. Two independent reviewers extracted data, and assessed risk of bias using Cochrane Risk of Bias Tool and evaluated the certainty of evidence using the GRADE-method. Results Eigthteen RCTs (n = 1477) comprised patients with prostate cancer stages T1-T4 were included in the meta-analyses. Compared to no exercise therapy, supervised exercise therapy showed clinically relevant improvements in ‘disease-specific quality of life’ and ‘walking performance’. The standardised mean differences were 0.43 (95% confidence interval (CI): 0.29, 0.58) and −0.41 (95% CI: −0.60, −0.22), respectively. The overall certainty of evidence was moderate due to serious risk of bias. Conclusions Evidence of moderate quality shows that supervised exercise therapy probably is superior to no exercise therapy in improving ‘disease-specific quality of life’ and ‘walking performance’ in patients with prostate cancer undergoing ADT. The results apply to all patients receiving androgen deprivation therapy regardless of cancer stage. The results support a strong recommendation for supervised exercise therapy for managing side effects in this population. Protocol registration NKR-38-Focused-questions-PICOs-for-updating1.ashx (sst.dk)

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“…At present, there are few drugs with definite curative effect specifically for cancerinduced sleep disturbance, with treatment being limited to supportive care, such as yoga, aerobic exercise, psycho-education, cognitivebehavioral strategies (Cramer et al, 2017;Kwekkeboom, 2016;Takemura et al, 2020). In addition, it has been reported that hormonal treatment and vitamin C can relieve cancer symptom clusters including sleep disturbance (Fritz et al, 2014;Tucci et al, 2018). However, the problem is far from settled.…”

Section: Introductionmentioning

confidence: 99%

1,25(OH)₂D₃ attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo

Chen

et al. 2021

Journal Cellular Physiology

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Many clinical studies have reported that patients diagnosed with cancer will suffer from sleep disturbance during their clinical process, especially among lung cancer patients, and this effect will not easily subside. 1,25-dihydroxy-vitamin-D 3 [1,25(OH) 2 D 3 ], the activated form of vitamin D, can participate in neuronal differentiation and prevent damage to the nervous system. However, little is known about the potential therapeutic effects of cancer-related psychiatric symptoms. In light of this, we hypothesized that a low circulating level of vitamin D was related to sleep quality in the presence of a tumor, 1,25(OH) 2 D 3 may be an effective way to ameliorate sleep disturbance and neurochemical alterations along with the cancer progress. Male C57BL/6 mice were implanted with intracranial transmitters to monitor electroencephalogram and were subcutaneously inoculated with Lewis lung cancer cells. The results demonstrated that on Days 19-20, tumor-bearing mice displayed fragmented sleep, shortened wake phase, prolonged sleep in the nonrapid eye movement phase, and the levels of vitamin D-associated genes in the brain had changed a lot compared to control mice. Importantly, 1,25(OH) 2 D 3 treatment really effectively saved the sleep quality of tumor-bearing mice. We further explored and confirmed that 1,25(OH) 2 D 3 repressed tumor-induced neuroinflammation (IL-1β, TNF-α, IL-6, IL-10, IFN-γ, and IL-2), enhanced neurotrophic factors (brain-derived neurotrophic factor [BDNF], glialcellline-derived neurotrophic factor) and 5-HT system in the hippocampus, hypothalamus or cortex. A molecular docking approah manifested the ability of 1,25(OH) 2 D 3 to affect the activity of tryptophan hydroxylase 2 and BDNF. Together, our results suggested that 1,25(OH) 2 D 3 treatment may attenuate sleep disturbance in Lewis lung cancer-bearing mice, and become a promising strategy for treating cancer symptom clusters to ameliorate the quality of life of patients with cancer.

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Hormonal treatment and quality of life of prostate cancer patients: new evidence

Cited by 38 publications

References 15 publications

An observational study evaluating the impact on prostate patient outcomes and experiences when radiation therapists use a standard grading system tool to assess and document treatment-related toxicities and interventions

An observational study evaluating the impact on prostate patient outcomes and experiences when radiation therapists use a standard grading system tool to assess and document treatment-related toxicities and interventions

Supervised exercise therapy compared with no exercise therapy to reverse debilitating effects of androgen deprivation therapy in patients with prostate cancer: a systematic review and meta-analysis

1,25(OH)₂D₃ attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo

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Hormonal treatment and quality of life of prostate cancer patients: new evidence

Cited by 38 publications

References 15 publications

An observational study evaluating the impact on prostate patient outcomes and experiences when radiation therapists use a standard grading system tool to assess and document treatment-related toxicities and interventions

An observational study evaluating the impact on prostate patient outcomes and experiences when radiation therapists use a standard grading system tool to assess and document treatment-related toxicities and interventions

Supervised exercise therapy compared with no exercise therapy to reverse debilitating effects of androgen deprivation therapy in patients with prostate cancer: a systematic review and meta-analysis

1,25(OH)2D3 attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo

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1,25(OH)₂D₃ attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo