Hormonal therapy using gonadotropin releasing hormone for improvement of fertility index among children with cryptorchidism: a meta-analysis and systematic review

Chua, Michael; Mendoza, Jonathan S.; Gaston, Michael John V.; Luna, Saturnino; Morales, Marcelino L.

doi:10.1016/j.jpedsurg.2014.06.013

Cited by 29 publications

(12 citation statements)

References 25 publications

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“…Boys with bilateral undescended testes suffer both lower fertility and paternity rates. Fertility rate is the number of offspring born per mating pair, individual of population, whereas paternity reflects the actual potential of fatherhood [68].…”

Section: Undescended Testes and Fertilitymentioning

confidence: 99%

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Radmayr

Doğan

Hoebeke

et al. 2016

Journal of Pediatric Urology

168

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Section: Undescended Testes and Fertilitymentioning

confidence: 99%

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Radmayr

Doğan

Hoebeke

et al. 2016

Journal of Pediatric Urology

168

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“…6 ). Chua et al supported these statements in a recent published meta-analysis on studies using gonadotrophin-releasing hormone for improvement of fertility index among children with cryptorchidism [ 43 ].…”

Section: Adjunctive Therapymentioning

confidence: 87%

Hormonal Treatment

Hutson¹,

Thorup²,

Beasley³

2015

Descent of the Testis

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Section: Role Of Hormonal Treatment In Cryptorchidismmentioning

confidence: 99%

“…In some studies, hormonal treatments, particularly GnRH, have been used before, but also after orchiopexy or orchiolysis (231). The aim has been to improve fertility potential in addition to the orchiopexy (231). This is based on the assumption that the hormonal surge during mini-puberty has a role in the transformation of gonocytes into Ad spermatogonia, which has been suggested to be important for male fertility (221,232).…”

Section: Role Of Hormonal Treatment In Cryptorchidismmentioning

confidence: 99%

“…The number of A dark spermatogonia from testicular biopsy at the time of orchiopexy was reported to predict the risk of infertility in adulthood (221,232). Some studies of GnRH administration, before (in most studies) or after orchiopexy or orchiolysis, showed increased fertility indices, as assessed by the number of germ cells or spermatogonia per tubular cross-section or percentage of normal histology from testicular biopsy in childhood, or semen quality (16,231,233,234). To date, there is only one study that reported a long-term effect of hormonal treatment on semen quality in adulthood (235), therefore the combined or sequential surgical and hormonal treatment cannot be recommended as routine practice at this time.…”

Section: Role Of Hormonal Treatment In Cryptorchidismmentioning

confidence: 99%

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Hypogonadism and Cryptorchidism

et al. 2020

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Congenital cryptorchidism (undescended testis) is one of the most common congenital urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born with normal birth weight ranges from 1.8 to 8.4%. Cryptorchidism is associated with a risk of low semen quality and an increased risk of testicular germ cell tumors. Testicular hormones, androgens and insulin-like peptide 3 (INSL3), have an essential role in the process of testicular descent from intra-abdominal position into the scrotum in fetal life. This explains the increased prevalence of cryptorchidism among boys with diseases or syndromes associated with congenitally decreased secretion or action of androgens, such as patients with congenital hypogonadism and partial androgen insensitivity syndrome. There is evidence to support that cryptorchidism is associated with decreased testicular hormone production later in life. It has been shown that cryptorchidism impairs long-term Sertoli cell function, but may also affect Leydig cells. Germ cell loss taking place in the cryptorchid testis is proportional to the duration of the condition, and therefore early orchiopexy to bring the testis into the scrotum is the standard treatment. However, the evidence for benefits of early orchiopexy for testicular endocrine function is controversial. The hormonal treatments using human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone (GnRH) to induce testicular descent have low success rates, and therefore they are not recommended by the current guidelines for management of cryptorchidism. However, more research is needed to assess the effects of hormonal treatments during infancy on future male reproductive health.

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Hormonal therapy using gonadotropin releasing hormone for improvement of fertility index among children with cryptorchidism: a meta-analysis and systematic review

Cited by 29 publications

References 25 publications

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Hormonal Treatment

Hypogonadism and Cryptorchidism

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