Hormonal therapy in advanced renal cell carcinoma

Abstract

A series of advanced renal cell carcinoma patients given clinical hormonal treatment is described. Eight cases (16.7%) showed objective signs of tumor regression with hormone therapy in our series of 43 consecutive cases of progressive metastatic renal cell carcinoma. Six out of 7 (objective) partial responses were from medroxyprogesterone acetate. The only case of complete regression of pulmonary metastases occurred in a female with testosterone therapy.

Adjuvant Therapy for Adenocarcinoma of the Kidney: Present Position and Prospects1

“…In this series and in most others, the best results, including the disappearance of tumour, have been confined to men. However, good objective responses in women have been reported by Samuels et al (1968) and also by Wagle and Murphy (1971).…”

Current status of the therapy of advanced renal carcinoma

“…Each of these nine studies includes a progestational agent, except that of Jenkin (13), wluch used androgens alone. The studies range in size There are nine studies in the literature prior to 1971 (2,13,18,22,23,25,(31)(32)(33) (13) with androgens alone] to 33% [4 of 12 patients treated by Papac (23) with progestins followed by androgens] . The response rates of most of the other studies hover very closely around the mean of a 17% objective response.…”

Androgen and Androgen Receptor in Kidney Cancer

“…[4][5][6][7][8] Despite the discovery of the therapeutic effects of both progesterone and androgen in RCC patients, their therapeutic outcomes had not been appreciated. 9 Since androgen and AR are involved in male-genderassociated diseases, recent studies have switched the focus to target androgen and AR signaling in RCC.…”