Hormonal Therapy and Cholelithiasis

Weiss, Gerald N.; Weiss, Elaine B.

doi:10.1097/00006254-197706000-00020

Cited by 2 publications

(4 citation statements)

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“…Several reports have indicated a relationship between estrogens, oral contraceptives, and conjugated estrogens, and an increased incidence of gallstones [266][267][268][269]. Similar findings have appeared for clofibrate, a drug used in the treatment of hyperlipidemia [270][271][272].…”

Section: Gallstonesmentioning

confidence: 59%

Drug-induced gastrointestinal disease

Hyson

Burrell

Toffler

1977

Gastrointest Radiol

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The gastrointestinal tract is a common target for adverse drug reactions. The resultant changes are often nonspecific (e.g., mucosal ulceration, intestinal infarction, motility disturbance) and in many cases no radiographically detectable lesion may occur. A comprehensive review of the reported drug-induced disorders of the digestive organs is herein presented and their radiographic manifestations are described.

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Section: Gallstonesmentioning

confidence: 59%

Drug-induced gastrointestinal disease

Hyson

Burrell

Toffler

1977

Gastrointest Radiol

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“…The effect of pregnancy on the occurrence of gallstone disease has been documented [10,11,12,13,14,15,16]. Women are more likely to develop gallstones than men [16,17].…”

Section: Discussionmentioning

confidence: 99%

“…There are several reports that suggest that the lithogenicity of estrogen is related to the increase in content of cholesterol in bile. Other studies report that the emptying of the gallbladder becomes poor during pregnancy [11,12,13,14]. Moreover, pregnant women gain weight, and it has been well known that obesity is a risk factor in the development of gallstones ever since Deaver first characterized patients at risk as "female, fair, fat, forty and fertile" [18].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, pregnant women gain weight, and it has been well known that obesity is a risk factor in the development of gallstones ever since Deaver first characterized patients at risk as "female, fair, fat, forty and fertile" [18]. In all, reviewing the literature [11,12,13,14,15,16], pregnancy is a very important pathogenic factor favoring gallstone formation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous hepatic duct perforation in pregnancy: a case report and review of the literature

et al. 2004

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Spontaneous perforation of the hepatic duct is a rare disease, and occurrence during pregnancy is even rarer. Treatment during pregnancy is crucial for both the mother and fetus. However, the treatment is a subject of controversy. We will discuss the case of an 18-year-old G1P1, 31 weeks pregnant, who showed acute onset of abdominal pain with peritoneal signs. She was taken to the operating room for exploratory laparotomy and was discovered to have a perforation of the common hepatic duct. Several factors thought to have caused spontaneous rupture of the bile tract were present: biliary calculi, infection, vessel thrombosis and pregnancy. The patient underwent a cholecystectomy, choledochotomy with removal of gallstones, repair of the perforation and placement of a T-tube. The postoperative course passed without problems for the mother and fetus. There were no complications, and the woman successfully carried her pregnancy to term. We conclude that the treatment of this unique and highly dangerous complication can be applied with an excellent outcome. The mechanism in this rare condition is discussed and reviewed.

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Hormonal Therapy and Cholelithiasis

Cited by 2 publications

References 0 publications

Drug-induced gastrointestinal disease

Drug-induced gastrointestinal disease

Spontaneous hepatic duct perforation in pregnancy: a case report and review of the literature

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