Hormonal replacement therapy in women with Turner's syndrome in Poland: Analysis of 176 cases

Wacław, Jeż; Irzyniec, Tomasz

doi:10.1080/09513590903015510

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Finally, it seems important to comment on the significantly higher FSH levels and the percentage of patients with FSH > 40 IU/L in GH+ group as compared to GH−, which was difficult to account for. In our previous study, we reported that a large percentage of women with TS did not use HRT; those who did used this method of treatment insufficiently, i.e., HRT doses were most likely too low 36 . However, some local effects of GH or GH degradation products on the secretion of other anterior pituitary hormones cannot be ruled out.…”

Section: Discussionmentioning

confidence: 94%

Childhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects

Irzyniec

Jeż

Lepska

et al. 2019

Sci Rep

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Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and biochemical findings of 33 TS women treated with GH in childhood (GH+) were compared to those of 124 TS women who did not receive GH (GH−). It seems that the GH-treated group might have had a more severe initial phenotype than the untreated group, as evidenced by higher FSH, more feeding issues in infancy, more lymphedema cases and urinary system malformations. GH+ women were significantly taller and had a better lipid profile and lower prevalence of arterial hypertension than GH− . However, they also had lower thrombocyte counts, a greater prevalence of retrognathism and nail anomalies, especially when the GH treatment was delayed. Long-term GH use was not as effective for growth as GH treatment during the initial period and seemed to have resulted in elevated creatinine levels. GH treatment in childhood has benefits in adulthood; however, adverse effects may occur, especially in individuals with treatment that is delayed or is too long.

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Section: Discussionmentioning

confidence: 94%

Childhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects

Irzyniec

Jeż

Lepska

et al. 2019

Sci Rep

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“…Although about 40% of these young women reported health problems, almost 13% did not consult any physician. According to one study, 14% did not take oestrogen replacement therapy (120), whilst in another, only half of young adults with TS used HRT (121).…”

Section: Complex Health Care During Transition In Studiesmentioning

confidence: 99%

“…In order to maintain feminisation and prevent osteoporosis, oestrogen replacement is usually required until the time of normal menopause (Table 4) (2). Still, recent studies have shown that a considerable percentage of TS patients discontinue therapy in adult life (120,121).…”

Section: Puberty/fertility In Transition Timementioning

confidence: 99%

TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

Gawlik

Małecka-Tendera

2014

European Journal of Endocrinology

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Transition in health care for young patients with Turner's syndrome (TS) should be perceived as a staged but uninterrupted process starting in adolescence and moving into adulthood. As a condition associated with high risk of short stature, cardiovascular diseases, ovarian failure, hearing loss and hypothyroidism, TS requires the attention of a multidisciplinary team. In this review paper, we systematically searched the relevant literature from the last decade to discuss the array of problems faced by TS patients and to outline their optimal management during the time of transfer to adult service. The literature search identified 233 potentially relevant articles of which 114 were analysed. The analysis confirmed that all medical problems present during childhood should also be followed in adult life. Additionally, screening for hypertension, diabetes mellitus, dyslipidaemia, and osteoporosis is needed. After discharge from the paediatric clinic, there is still a long way to go.

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The influence of hormonal replacement and growth hormone treatment on the lipids in Turner syndrome

Irzyniec

Wacław²

2014

Gynecological Endocrinology

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Hormonal replacement therapy in women with Turner's syndrome in Poland: Analysis of 176 cases

Abstract: (1) Large percentage of women with TS does not use HRT. (2) Women with TS, who receive HRT, use this method of treatment insufficiently.

Cited by 3 publications

References 11 publications

Childhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects

Childhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects

TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

The influence of hormonal replacement and growth hormone treatment on the lipids in Turner syndrome

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