Hormonal replacement therapy in patients after cervical cancer treatment

Iatrogenic Menopause After Treatment for Cervical Cancer

“…Any complications that were present were milder and of shorter duration when compared with those women in the control group who did not receive HRT, p<0.01) [62]. Topical oestrogens are highly effective at relieving urogenital symptoms related to vaginal atrophy [63].…”

“…Oestrogen containing HRT has been shown to be effective in managing menopausal symptoms after radiotherapy for cervical cancer with a reduced incidence of postradiotherapy complications [62]. Any complications that were present were milder and of shorter duration when compared with those women in the control group who did not receive HRT, p<0.01) [62].…”

“…There is only one randomised, controlled trial in the literature investigating the effect on HRT on survival for women treated with radiotherapy alone or combined with surgery for a stage I/II cervical cancer [62]. No significant difference in cervical cancer recurrence or in overall survival was seen at the end of 5-years between women who took HRT and those who did not therefore women using HRT should be reassured that HRT does not appear to cause an increase in recurrence of cervical cancer.…”

Menopause and Cancers

“…74 Hormone therapy is not contraindicated in women with cervical cancer and should be considered for the treatment of menopausal symptoms. 75,76 …”

Hormonal Replacement Therapy after Gynaecological Cancer

“…Furthermore, the squamous cervical cancer is not considered responsive to oestrogens, though oestrogen receptors can be found in the neoplastic tissue. Ploch [41] compared 80 women with stage I-II cervical cancer treated with HRT and 40 nontreated women, with no significant change either in survival or disease-free survival at 5 years, even if women in the HRT group experienced fewer radiotherapeutic complications.…”