Hormonal Relationships to Bone Mass in Elderly Spanish Men as Influenced by Dietary Calcium and Vitamin D

Abstract

We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men. Serum PTH and 25-OH-Vitamin D3 were measured in 195 healthy elderly men (mean age: 73.31 ± 5.10 year). Food intake was quantified using a dietetic scale. Participants with 25-OH-Vitamin D3 levels ≥ 30 ng/mL (75 nmol/L) and a calcium intake of 800–1200 mg/day exhibited the lowest PTH levels (41.49 ± 16.72 ng/mL). The highest PTH levels (75.60 ± 14.16 ng/mL) were observed in the <30 ng/mL group 25-OH-Vitamin D3 with a calcium intake >1200 mg/day. No significant differences in the serum PTH levels based on the serum 25-OH-Vitamin D3 levels were observed among participants with a calcium intake of 800–1200 mg/day. Serum PTH was inversely correlated with serum 25-OH-Vitamin D3 in the entire patient sample (r = −0.288, p = 0.019). No differences in any of the three densitometry techniques were observed between any of the age groups in the 800–1200 mg/day and >1200 mg/day calcium intake groups. PTH levels correlate negatively with serum 25-OH-Vitamin D3 levels, and neither calcium nor vitamin D intake exert a strong influence on either of the two parameters.

Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

“…Total dietary vitamin D, calcium and energy intake were assessed via validated frequency questionnaires as previously described ( Calderon-Garcia et al, 2013 ; Moran et al, 2013 ).…”

The Daily Consumption of Cola Can Determine Hypocalcemia: A Case Report of Postsurgical Hypoparathyroidism-Related Hypocalcemia Refractory to Supplemental Therapy with High Doses of Oral Calcium

“…Other previous reports described a significant effect of cola on bone ( 9 ). Indeed, diets full of phosphorus and low in calcium lead to complexes that reduce serum calcium, stimulating PTH, which, in turn, causes bone resorption.…”

“…In both the clinical ( 4 , 5 ) and experimental settings ( 6 ), heavy consumption of cola soft drinks is associated with hypocalcemia, and with increased risk of bone fractures ( 7 – 9 ). Indeed, it is well known that in patients with normally functioning parathyroids, oral or parenteral phosphate intake can decrease serum calcium levels by reducing calcium intestinal absorption or increasing calcium excretion ( 10 ).…”

Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs

“…We did not observe any case of vitamin D deficiency, but the QUS technique was able to detect bone mass differences between the groups. Most patients in our study were ambulant and the sunlight exposure in our area is one of the greatest in Spain [ 36 ], so vitamin D deficiency could not be a key determinant of bone mass in Spanish children.…”