Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation

Da, Nguyen; Af, Parlow; Mc, Neville

doi:10.1677/joe.0.1700347

Cited by 162 publications

(139 citation statements)

References 28 publications

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“…Indeed, the decrease in plasma IgG occurred when plasma P4 concentrations were still high. Moreover, P4 was shown to prevent closure of tight junctions between lactocytes in the mouse [10,11] and, when associated with E2, to enable paracellular transfer of immunoglobulins from plasma to the alveolar lumen of mammary glands in the cow [41]. In sows, Jackson et al [42] confirmed the positive role of P4 on IgG transfer by showing higher colostrum concentrations of IgG in sows treated with P4 and farrowing at 116 days of gestation instead of 114 days.…”

Section: Plasma Hormones Lactose and Igg Variations Around Parturitionmentioning

confidence: 94%

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Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

et al. 2004

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-Blood, colostrum and saliva samples were serially taken from 6 multiparous sows from day 109 of gestation until day 3 postpartum. Plasma was assayed for oestradiol-17β (E2), progesterone (P4), prolactin (PRL), cortisol, immunoglobulin G (IgG) and lactose. Colostrum was assayed for E2, P4, IgG and lactose. Lactoserum, obtained after ultra centrifugation of colostrum, was assayed for PRL. Saliva was assayed for cortisol. Time-related variations in hormone, IgG and lactose concentrations measured in plasma were parallel to those measured in colostrum, lactoserum or saliva. However, the concentrations were higher in colostrum or lactoserum and lower in saliva than in plasma. Ratios of concentrations of cortisol in saliva and PRL in lactoserum over those in plasma did not vary with time and averaged 0.2 and 1.6, respectively. Conversely, the ratios of concentrations of E2 and P4 in colostrum over those in plasma varied with time (P < 0.05) but were quite constant before the end of parturition, averaging 2.7 and 3.6, respectively. The ratios of concentrations of IgG and lactose in colostrum over those in plasma also varied with time (P < 0.05). The concentrations of hormones in plasma on the one hand and in colostrum, lactoserum or saliva on the other hand were significantly correlated but correlations varied with time (PRL across periods: r = 0.31; cortisol across periods: r = 0.60; E2 during parturition: r = 0.83; P4 before parturition: r = 0.82; P4 during parturition: r = 0.67). The present results indicate that around parturition, assays of hormones in colostrum or saliva can be used to study the hormonal status of sows. Furthermore, variations in colostrum and plasma concentrations of IgG and lactose are good indicators of the transition from colostrum to milk synthesis. sow / parturition / steroid / prolactin / lactose / immunoglobulins

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Section: Plasma Hormones Lactose and Igg Variations Around Parturitionmentioning

confidence: 94%

“…It can be depicted from variations of concentrations of Ig and lactose in colostrum and plasma. This closure occurs between 24 and 36 h after the onset of parturition and is under the control of P4, cortisol and PRL [10,11].…”

Section: Introductionmentioning

confidence: 99%

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

et al. 2004

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“…Insulin-like growth factor 1 (IGF1; 7.6 kDa), another member of the insulin family of hormones, is found in porcine colostrum at high concentrations (Simmen et al 1990a, which decline within the first 24-36 h of lactation during the transition from colostrum to mature milk (Klobasa et al 1987, Nguyen et al 2001. In the porcine neonate, a window for transmission of macromolecules, including MbFs, is open before gut closure, which is estimated to occur within 48 h of birth (Leece 1973).…”

Section: Introductionmentioning

confidence: 99%

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Camp¹,

Wiley²,

Boulos³

et al. 2014

Reproduction

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Nursing supports neonatal porcine uterine and testicular development, however, lactocrine effects on cervical development are undefined. Studies were conducted to determine the effects of i) age and the imposition of the lactocrine-null state from birth (postnatal day 0 (PND0)) by milk replacer feeding on cervical histology; ii) imposition of the lactocrine-null state for 2 days from birth on cervical cell proliferation, as reflected by proliferating cell nuclear antigen immunostaining; and iii) a single feeding of colostrum or milk replacer, administered at birth, with or without oral IGF1, on cervical cell proliferation and phosphorylated AKT (pAKT) and B-cell lymphoma 2 (BCL2) protein levels at 12 h postnatal. Cervical crypt depth and height of luminal epithelium (LE) increased with age by PND14, when both responses were reduced in replacer-fed gilts. Cell proliferation was reduced in LE at PND2, and in crypt epithelium and stroma by PND14 in replacer-fed gilts. Returning replacer-fed gilts to nursing on PND2 did not rescue the cervical phenotype by PND14. A single feeding of colostrum, but not milk replacer, was sufficient to support cervical cell proliferation at 12 h postnatal. IGF1 supplementation induced cell proliferation in replacer-fed gilts, and increased cervical pAKT and BCL2 levels in colostrum-fed gilts and replacer-fed gilts at 12 h postnatal. Results indicate that age and nursing support porcine cervical development, support is initiated at first ingestion of colostrum, IGF1 may be lactocrine-active, and identification of lactocrine-active factors can be accomplished by 12 h postnatal using this bioassay system.

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“…For example, the mammary epithelium reorganizes during distinct stages of the ovarian cycle in preparation for lactation. [16][17][18] Conversely, pathogens may destabilize homotypic interactions between adjacent cells and thereby destabilize the epithelial monolayer to gain entry. 19,20 Although many of the components involved in cellular communication are known, identifying the regulatory networks that control the collective cellular response within tissues remains a challenge.…”

Section: Tissues As Dynamic Systemsmentioning

confidence: 99%

Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling

Klinke

2015

Molecular & Cellular Oncology

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In the past decade, cumulative clinical experiences with molecular targeted therapies and immunotherapies for cancer have promoted a shift in our conceptual understanding of cancer. This view shifted from viewing solid tumors as a homogeneous mass of malignant cells to viewing tumors as heterogeneous structures that are dynamically shaped by intercellular interactions among the variety of stromal, immune, and malignant cells present within the tumor microenvironment. As in any dynamic system, identifying how cells communicate to maintain homeostasis and how this communication is altered during oncogenesis are key hurdles for developing therapies to restore normal tissue homeostasis. Here, I discuss tissues as dynamic systems, using the mammary gland as an example, and the evolutionary concepts applied to oncogenesis. Drawing from these concepts, I present 2 competing hypotheses for how intercellular communication might be altered during oncogenesis. As an initial test of these competing hypotheses, a recent secretome comparison between normal human mammary and HER2C breast cancer cell lines suggested that the particular proteins secreted by the malignant cells reflect a convergent evolutionary path associated with oncogenesis in a specific anatomical niche, despite arising in different individuals. Overall, this study illustrates the emerging power of secretome proteomics to probe, in an unbiased way, how intercellular communication changes during oncogenesis.

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Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation

Cited by 162 publications

References 28 publications

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling

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