Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise

Saracino, Patrick G.; Rossetti, Michael L.; Steiner, Jennifer L.; Gordon, Bradley S.

doi:10.1016/j.bbrc.2018.12.034

Cited by 30 publications

(31 citation statements)

References 31 publications

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“…Treadmill running acutely increases Per1 and Per2 expression in mouse plantaris muscle 1 h following the exercise bout (Saracino et al . 2019). This increase in Per1 , but not Per2 expression, was attributed to exercise‐secreted hormones such as epinephrine.…”

Section: Discussionmentioning

confidence: 99%

Contraction influences Per2 gene expression in skeletal muscle through a calcium‐dependent pathway

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Laker

et al. 2020

The Journal of Physiology

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Exercising at different times of day elicits different effects on exercise performance and metabolic health. However, the specific signals driving the observed time-of-day specific effects of exercise have not been fully identified. r Exercise influences the skeletal muscle circadian clock, although the relative contribution of muscle contraction and extracellular signals is unknown. r Here, we show that contraction acutely increases the expression of the core circadian clock gene Period Circadian Regulator 2 (Per2) and phase-shifts Per2 rhythmicity in muscle cells. This contraction effect on core clock genes is mediated through a calcium-dependant mechanism; r The results obtained in the present study suggest that a proportion of the ability of exercise to entrain the skeletal muscle clock is driven directly by muscle contraction. Contraction interventions may be used to mimic some time-of-day specific effects of exercise on metabolism and muscle performance.

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Section: Discussionmentioning

confidence: 99%

Contraction influences Per2 gene expression in skeletal muscle through a calcium‐dependent pathway

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Altıntaş

Laker

et al. 2020

The Journal of Physiology

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“…The central pacemaker of this rhythm is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The positive and negative feedback loops of the circadian proteins BMAL1, CLOCK, PER1, and PER2 regulate various physiological processes of the human body, including blood pressure, hormone secretion, sleep and immune activities [3–6]. Circadian rhythm disorders may increase the risk of diseases such as cardiovascular disease, immune system diseases and cancer [7–10].…”

Section: Introductionmentioning

confidence: 99%

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression

Wang

et al. 2019

Cancer Cell Int

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Background Metastasis is an important factor in the poor prognosis of breast cancer. As an important core clock protein, brain and muscle arnt-like 1 (BMAL1) is closely related to tumorigenesis. However, the molecular mechanisms that mediate the role of BMAL1 in invasion and metastasis remain largely unknown. In this study, we investigated the BMAL1 may take a crucial effect in the progression of breast cancer cells. Methods BMAL1 and MMP9 expression was measured in breast cell lines. Transwell and scratch wound-healing assays were used to detect the movement of cells and MTT assays and clonal formation assays were used to assess cells’ proliferation. The effects of BMAL1 on the MMP9/NF-κB pathway were examined by western blotting, co-immunoprecipitation and mammalian two-hybrid. Results In our study, it showed that cell migration and invasion were significantly enhanced when overexpressed BMAL1. Functionally, overexpression BMAL1 significantly increased the mRNA and protein level of matrix metalloproteinase9 (MMP9) and improved the activity of MMP9. Moreover, BMAL1 activated the NF-κB signaling pathway by increasing the phosphorylation of IκB and promoted human MMP9 promoter activity by interacting with NF-kB p65, leading to increased expression of MMP9. When overexpressed BMAL1, CBP (CREB binding protein) was recruited to enhance the activity of p65 and further activate the NF-κB signaling pathway to regulate the expression of its downstream target genes, including MMP9, TNFα, uPA and IL8, and then promote the invasion and metastasis of breast cancer cells. Conclusions This study confirmed a new mechanism by which BMAL1 up-regulated MMP9 expression to increase breast cancer metastasis, to provide research support for the prevention and treatment of breast cancer.

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“…Here, adrenaline increased the mRNA of Redd1 and the core clock component Per1 in a manner similar to that observed in mouse skeletal muscle 1 hour after acute aerobic exercise. 58 Similar to glucocorticoids, these data suggest that adrenaline may also contribute to the regulation of REDD1-controlled processes as well as entrainment of the skeletal muscle core clock via genomic effects ( Figure 4B).…”

Section: Catecholamines and Aerobic Exercise Trainingmentioning

confidence: 80%

“…Firstly, the induction of Redd1 and Per1 mRNA that occurred in the plantaris of mice following acute aerobic exercise (discussed above) was also mimicked by treating C 2 C 12 myotubes with 50 nM aldosterone for a time that recapitulated acute exercise (1.5 hours). 58 This indicates that aldosterone may regulate both REDD1-sensitive gene programmes and core clock entrainment in the skeletal muscle in a manner that is similar to glucocorticoids and adrenaline ( Figure 6B). Further, treatment of human myotubes with aldosterone for 48 hours increased the mRNA expression of JUNB, 175 which was previously shown to be increased in the skeletal muscle of mice following acute aerobic exercise in a REDD1-dependent manner.…”

Section: Aldosterone and Aerobic Exercisementioning

confidence: 94%

Adrenal stress hormone action in skeletal muscle during exercise training: An old dog with new tricks?

et al. 2020

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Exercise is a key component of a healthy lifestyle as it helps maintain a healthy body weight and reduces the risk of various morbidities and co‐morbidities. Exercise is an acute physiological stress that initiates a multitude of processes that attempt to restore physiological homeostasis and promote adaptation. A component of the stress response to exercise is the rapid release of hormones from the adrenal gland including glucocorticoids, the catecholamines and aldosterone. While each hormone targets several tissues throughout the body, skeletal muscle is of interest as it is central to physical function and various metabolic processes. Indeed, adrenal stress hormones have been shown to elicit specific performance benefits on the muscle. However, how the acute, short‐lived release of these stress hormones during exercise influences adaptations of skeletal muscle to long‐term training remains largely unknown. Thus, the objective of this review was to briefly highlight the known impact of adrenal stress hormones on skeletal muscle metabolism and function (Old Dog), and critically examine the current evidence supporting a role for these endogenous hormones in mediating long‐term training adaptations in skeletal muscle (New Tricks).

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Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise

Cited by 30 publications

References 31 publications

Contraction influences Per2 gene expression in skeletal muscle through a calcium‐dependent pathway

Contraction influences Per2 gene expression in skeletal muscle through a calcium‐dependent pathway

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression

Adrenal stress hormone action in skeletal muscle during exercise training: An old dog with new tricks?

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