Hormonal regulation of complement biosynthesis in human cell lines—II. Upregulation of the biosynthesis of complement components C3, factor B and Cl inhibitor by interleukin-6 and interleukin-1 in human hepatoma cell line

Falus, András; Rokita, Hanna; Walcz, E; Brózik, Márta; Hidvegi, Tunda; Merétey, K.

doi:10.1016/0161-5890(90)90115-g

Cited by 58 publications

(24 citation statements)

References 20 publications

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“…Several of these cytokines (IL-1 and IL-6, for example), have been shown to up-regulate C3 transcription (19). We suggest that these cytokines may gain access to the proximal tubular epithelium and the epithelium of Bowman's capsule via glomerular filtrate or, in the case of the proximal tubule, the vasa recta.…”

Section: Discussionmentioning

confidence: 83%

Evidence of a Role for Local Complement Expression in a Murine Model of Progressive Glomerulonephritis

2000

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Section: Discussionmentioning

confidence: 83%

Evidence of a Role for Local Complement Expression in a Murine Model of Progressive Glomerulonephritis

2000

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“…Moreover, IL-6 also stimulates production of CRP, which has been shown to activate the classical complement pathway and stimulate production of C3 (Jarav, et al, 1999). Interestingly, IL-6 (and IL-1) does not appear to affect the biosynthesis of C4 (Falus, et al, 1990;Kulics, et al, 1990) that could explain the nonsignificant relation of psychological attributes to C4.…”

Section: Discussionmentioning

confidence: 93%

Hostility, anger, and depression predict increases in C3 over a 10-year period

Boyle¹,

Jackson²,

Suarez³

2007

Brain, Behavior, and Immunity

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We examined the relation of hostility, anger and depression to 10-year changes in the third (C3) and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health consequences of dioxin exposure. Hostility, depression and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997 and 2002. Regression analyses controlling for age, race, alcohol use, body mass index and cigarette use as well as onset of disease and use of lipid lowering and blood pressure medications during follow-up revealed a significant time X composite score interaction for C3 complement (p < .0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease.

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“…Since IL-6 levels are elevated in active SLE (20,40) and can stimulate hepatic secretion of C3 as an acute-phase reactant (41), decreased levels of C3 during prasterone treatment may reflect either a direct or an indirect effect on hepatic C3 production. Decreased serum C3 complement levels were observed during administration of prasterone 200 mg/day to normal premenopausal women who were participating in a preclinical pharmacokinetic/pharmacodynamic study (Genelabs, Inc.: unpublished observations), which is consistent with a physiologic effect of prasterone on hepatic complement production.…”

Section: Discussionmentioning

confidence: 99%

Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus

Petri¹,

Mease²,

Merrill³

et al. 2004

Arthritis & Rheumatism

132

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Objective. To determine whether prasterone administration results in improvement or stabilization of systemic lupus erythematosus (SLE) disease activity and its symptoms.Methods. Women with active SLE were treated with prasterone 200 mg/day plus standard SLE treatments or with placebo plus standard SLE treatments for up to 12 months in this randomized, double-blind investigation conducted at 27 centers. Standard SLE treatments included prednisone (<10 mg/day), antimalarials, and immunosuppressive agents; dosages were required to be stable for >6 weeks prior to enrollment and remain unchanged during protocol treatment. Re-

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Hormonal regulation of complement biosynthesis in human cell lines—II. Upregulation of the biosynthesis of complement components C3, factor B and Cl inhibitor by interleukin-6 and interleukin-1 in human hepatoma cell line

Cited by 58 publications

References 20 publications

Evidence of a Role for Local Complement Expression in a Murine Model of Progressive Glomerulonephritis

Evidence of a Role for Local Complement Expression in a Murine Model of Progressive Glomerulonephritis

Hostility, anger, and depression predict increases in C3 over a 10-year period

Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus

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