Hormonal Regulation of Cell Division in Epithelial and Connective Tissues of the Mouse Uterus

Martin, L.; Finn, C. A.

doi:10.1677/joe.0.0410363

Cited by 200 publications

(121 citation statements)

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“…Mitosis in the luminal and glandular epithelium is observed just prior to implantation in mice (Finn & Martin 1967), ferrets (Gulamhusein & Beck 1973) and horses (Gerstenberg et al 1999). In vitro, this mitosis is stimulated by oestrogen (Martin & Finn 1968), and the mitosis just prior to implantation is presumed to be a delayed response to the pre-ovular oestrogen in mice (Tranguch et al 2005), but is thought to be a response to conceptus-secreted oestrogen in horses (Gerstenberg et al 1999). The final mitotic pulse observed here occurred in both pregnant and non-pregnant cycles.…”

Section: Discussionmentioning

confidence: 99%

Progesterone concentration in the marsupial Sminthopsis macroura: relationship with the conceptus, uterine glandular regeneration and body weight

2009

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Close examination of hormonal profiles and uterine morphology in the marsupial reproductive cycle highlights significant differences between pregnant and non-pregnant cycles. In the polyovular dasyurid marsupial Sminthopsis macroura, we identified changes associated with gestation by comparing ovarian and plasma progesterone concentrations, uterine weights, uterine epithelial mitoses, body weights and gestation lengths between pregnant and non-pregnant luteal phases. The plasma progesterone profile of S. macroura was biphasic, peaking during unilaminar blastocyst expansion and on the day of implantation. Periods of rapid embryonic development were associated with increasing plasma progesterone concentrations and animal body weight. For the first time in a polyovular marsupial, we identified 1) a correlation between ovarian progesterone concentration and conceptus number during the luteal phase just prior to implantation (total ovarian progesterone), indicating a conceptus influence on progesterone concentration; 2) a pulse of uterine epithelial mitotic activity at the time of implantation and 3) increased mitotic activity in pregnant animals during unilaminar blastocyst formation compared with non-pregnant animals. Gestation length was reduced by up to 15%, due to the loss of, or reduction in, the fourcell arrest and more rapid definitive blastocyst expansion. This is the first time a conceptus influence on gestation length has been identified in a dasyurid. This study provides further evidence for the modification of the luteal phase by pregnancy in S. macroura.

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Section: Discussionmentioning

confidence: 99%

Progesterone concentration in the marsupial Sminthopsis macroura: relationship with the conceptus, uterine glandular regeneration and body weight

2009

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“…To obtain glandular mitosis required 3 days' treatment with oestrogen (Table 4). Progesterone alone stimulated some cell proliferation in the stroma, although the mitotic counts were very much lower than those Martin & Finn, 1968) is critical in implantation; lack of stromal mitosis may not be so important. In the mouse, the blastocyst itself stimulates mitosis in the stroma (Finn & Martin, 1967) at the time of implanta¬ tion and a similar effect in the guinea-pig may compensate for the lack of hormonally stimulated stromal cell proliferation.…”

Section: Introductionmentioning

confidence: 87%

“…The patterns of cell proliferation in the tissues of the endometrium associated with the preparation of the uterus for implantation have been studied exten¬ sively in mice (Finn & Martin, 1967) and rats (Clark, 1971;Chaudhury & Sethi, 1970) and the hormonal control has been worked out in some detail (Martin & Finn, 1968).…”

Section: Introductionmentioning

confidence: 99%

Cell Proliferation in the Uterus of the Guinea-Pig

Mehrotra¹,

Finn²

1974

Reproduction

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Summary. The pattern of cell division in the uterus of the guinea-pig has been studied, during the oestrous cycle (with and without mating) and after treatment of ovariectomized animals with ovarian hormones.During the oestrous cycle, there were many luminal epithelial cells undergoing mitosis just before and after the time of ovulation whilst mitosis counts in the glandular epithelium were maximal about 4 days after ovulation. In the stroma, cell division reached a peak on Day 6 of the cycle, just before the expected time of implantation.In ovariectomized animals, mitosis was stimulated by exogenous oestradiol, indicating that epithelial mitosis during the cycle is associated with follicular oestrogen secreted during pro-oestrus. Progesterone alone stimulated only a few mitoses in the stroma, but the number was increased considerably by the addition of a small quantity of oestradiol. This indicates that luteal progesterone cannot be solely responsible for the very high level of stromal mitosis on Days 5 and 6 of the cycle and suggests that some oestrogen is also being secreted at this time.

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“…2) (Martin and Finn 1968;Sandow et al 1979). Estrogen promotes epithelial cell proliferation in the uterine endometrium (Pollard et al 1987).…”

Section: Uterine Endometriummentioning

confidence: 99%

Hormonal regulation of physiological cell turnover and apoptosis

Medh

Thompson

2000

Cell Tissue Res

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Physiological cell turnover plays an important role in maintaining normal tissue function and architecture. This is achieved by the dynamic balance of cellular regeneration and elimination, occurring periodically in tissues such as the uterus and mammary gland, or at constant rates in tissues such as the gastrointestinal tract and adipose tissue. Apoptosis has been identified as the prevalent mode of physiological cell loss in most tissues. Cell turnover is precisely regulated by the interplay of various endocrine and paracrine factors, which modulate tissue and cell-specific responses on proliferation and apoptosis, either directly, or by altering expression and function of key cell proliferative and/or death genes. Although recent studies have provided significant information on specific tissue systems, a clearly defined pathway that mediates cell turnover has not yet emerged for any tissue. Several similarities exist among the various tissues with regard to the intermediates that regulate tissue homeostasis, enabling a better understanding of the general mechanisms involved in the process. Here we review the mechanisms by which hormonal and cytokine factors mediate cell turnover in various tissues, emphasizing common themes and tissue-specific differences.

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Hormonal Regulation of Cell Division in Epithelial and Connective Tissues of the Mouse Uterus

Cited by 200 publications

References 0 publications

Progesterone concentration in the marsupial Sminthopsis macroura: relationship with the conceptus, uterine glandular regeneration and body weight

Progesterone concentration in the marsupial Sminthopsis macroura: relationship with the conceptus, uterine glandular regeneration and body weight

Cell Proliferation in the Uterus of the Guinea-Pig

Hormonal regulation of physiological cell turnover and apoptosis

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