Hormonal profile in Indian men with premature androgenetic alopecia

Narad, Smita; Pande, Sushil; Gupta, Madhur; Chari, Suresh

doi:10.4103/0974-7753.122961

Cited by 26 publications

(40 citation statements)

References 21 publications

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“…In our study, the mean value of testosterone in cases was significantly higher as compared to controls in agreement with studies by Narad et al [11], Schmidt et al [12] and Yildiaz et al [13]. However, Duskova et al [14] and Starka et al [15] showed subnormal levels of testosterone in their cases.…”

Section: Discussionsupporting

confidence: 82%

“…Similar findings were noted by Duskova et al [14] and Narad et al [11] lower the levels of SHBG, higher the free testosterone and thus hyperandrogenism.…”

Section: Discussionsupporting

confidence: 79%

“…However, Narad et al. [11] and Schtmidt et al [12] found normal values of DHEAS in their studies. Increased levels of DHEAS indirectly point towards increased androgens.…”

Section: Discussionmentioning

confidence: 91%

See 2 more Smart Citations

Free Androgen Index (FAI): Marker of Premature Androgenetic Alopecia in Men

Sanke¹,

Ch²,

er³

et al. 2016

J Microb Biochem Technol

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Section: Discussionsupporting

confidence: 82%

“…Similar findings were noted by Duskova et al [14] and Narad et al [11] lower the levels of SHBG, higher the free testosterone and thus hyperandrogenism.…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Free Androgen Index (FAI): Marker of Premature Androgenetic Alopecia in Men

Sanke¹,

Ch²,

er³

et al. 2016

J Microb Biochem Technol

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“…[12][13][14] However, most authors have defined premature or early-onset alopecia as starting before age 30 years. 12,[16][17][18][19][20] According to most studies, patterned hair loss in men occurring before age 30 years is considered the phenotypic equivalent of PCOS. 5,6,9,10 Hence, the age group of 19 to 30 years was used in our study to define early AGA.…”

mentioning

confidence: 99%

A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women

et al. 2016

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IMPORTANCE Early androgenetic alopecia (AGA) is patterned hair loss occurring before age 30 years. Early AGA in men is frequently reported as the phenotypic equivalent of polycystic ovarian syndrome (PCOS) in women, which carries the risk of developing obesity, metabolic syndrome, and cardiovascular diseases. Very few studies have been conducted to evaluate this.OBJECTIVE To study the hormonal profile of men with early AGA and to evaluate if early AGA in men can be considered as the phenotypic equivalent of PCOS, the associated risks of which are well known. DESIGN, SETTING, AND PARTICIPANTSThis case-control study was conducted from January 1, 2014, to March 31, 2015, in a tertiary care government hospital. Fifty-seven men aged 19 to 30 years presenting with patterned hair loss were recruited as study participants. Thirty-two age-matched men with no evidence of hair loss were recruited as controls. Men who had any established endocrine disorder, diabetes mellitus, or cardiovascular disease and those who took any oral medication or hormonal treatment for hair loss were excluded from the study. The serum concentrations of total testosterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, fasting plasma glucose, and insulin levels were measured. Insulin resistance (IR) and free androgen index (FAI) were calculated and compared with age-and sex-matched controls. MAIN OUTCOMES AND MEASURESThe primary outcome was to measure the clinico-endocrinological profiles (LH, FSH, SHBG, DHEAS, and testosterone levels) of men with early AGA and to compare it with the PCOS profile; the secondary outcome was to establish a relationship between this endocrinological profile and IR.RESULTS Compared with the 32 controls, the 57 participants with AGA showed significantly increased mean (SD) levels of testosterone (24.61 [7.97] vs 20.57 [4.9] nmol/L; P = .04), DHEAS (3.63 [2.19] vs 2.64 [1.49] μg/mL; P = .02), LH (7.78 [3.19] vs 4.56 [2.01] mIU/mL; P < .001), and prolactin (14.14 [9.48] vs 9.97 [3.12] ng/mL; P = .01) and decreased mean levels of FSH (4.02 [2.69] vs 5.66 [1.93] mIU/mL; P < .001) and SHBG (35.07 [11.11] vs 46.41 [14.03] nmol/L; P < .001). The mean FAI and LH/FSH ratio were was also increased in the AGA group. These hormonal parameters resemble the well-known profile of women with PCOS. The mean (SD) insulin levels did not show any significant difference between the cases and controls (6.34 [3.92] vs 5.09 [3.38] μIU/mL; P = .07). There was no statistically significant association between hormone levels and AGA or IR grade severity.CONCLUSIONS AND RELEVANCE Men with early AGA could be considered as male phenotypic equivalents of women with PCOS. They can be at risk of developing the same complications associated with PCOS, including obesity, metabolic syndrome, IR, cardiovascular diseases, and infertility.

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“…It has also been recently proven that thyroid abnormalities are strongly associated with hair growth [8]. There is a putative role of glucocorticosteroids and prolactin in hair biology [9,10]. The role of parathyroid hormone (PTH) and abnormalities of parathyroid gland function in hair growth remains not well understood.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia

Skrok

Bednarczuk

Skwarek

et al. 2015

Skin Pharmacol Physiol

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Parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) influence hair follicles through paracrine and intracrine routes. There is significant evidence that PTH and PTHrP influence the proliferation and differentiation of hair follicle cells. The PTH/PTHrP receptor signalling plays an important role in the hair follicle cycle and may induce premature catagen-telogen transition. Transgenic mice with an overexpression or blockade (PTH/PTHrP receptor knockout mice) of PTHrP activity revealed impaired or increased hair growth, respectively. Some findings also suggest that PTHrP may additionally influence the hair cycle by inhibiting angiogenesis. Antagonists of the PTH/PTHrP receptor have been shown to stimulate proliferation of hair follicle cells and hair growth. A hair-stimulating effect of a PTH/PTHrP receptor antagonist applied topically to the skin has been observed in hairless mice, as well as in mice treated with cyclophosphamide. These data indicate that the PTH/PTHrP receptor may serve as a potential target for new (topical) hair growth-stimulating drugs, especially for chemotherapy-induced alopecia.

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Hormonal profile in Indian men with premature androgenetic alopecia

Cited by 26 publications

References 21 publications

Free Androgen Index (FAI): Marker of Premature Androgenetic Alopecia in Men

Free Androgen Index (FAI): Marker of Premature Androgenetic Alopecia in Men

A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women

The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia

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