Hormonal monitoring of early pregnancy by a direct radioimmunoassay of steroid glucuronides in first morning urine

Mendizabal, A. F.; Quiroga, S.; Farinati, Zulema; Lahoz, Mónica; Nagle, Carlos A.

doi:10.1016/s0015-0282(16)48199-9

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Concentrations increase very early in gestation, decline in the fourth or fifth week after implantation, and then increase as the placenta becomes the primary source of progesterone [14,15]. However, there are few data on change in progesterone levels around the time of implantation, data that would reflect the time of CL rescue [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Rescue of the Corpus Luteum in Human Pregnancy1

Baird

Weinberg

McConnaughey

et al. 2003

Biology of Reproduction

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Rescue of the corpus luteum from its programmed senescence maintains progesterone production required for pregnancy. In primates, chorionic gonadotropin produced by the developing conceptus acts as the primary luteotrophic signal. The purpose of this research was to assess corpus luteum rescue by examining changes in daily urinary progesterone metabolite levels during the first week after implantation. We determined the variability in progesterone metabolite profiles and evaluated its relationship to early pregnancy loss in 120 naturally conceived human pregnancies, including 43 early pregnancy losses. In other primates, an abrupt increase in the progesterone metabolite occurs at the time of implantation. This pattern occurred in an estimated 45% of the pregnancies in the present study. In the remaining pregnancies, there was a delayed rise (18%), neither a rise or decline (22%), or a decline (15%) during the week after implantation. The estimated rate of early pregnancy loss increased across these categories (from 5% loss with an abrupt rise at implantation to 100% loss with progesterone metabolite decline). Low urinary hCG levels in early pregnancy were significant determinants of a decline in postimplantation progesterone metabolite. However, preimplantation steroid metabolite levels were not significant, suggesting no inherent problem with the corpus luteum. Examination of individual progesterone metabolite profiles in relation to hCG profiles also indicated that few losses were caused by corpus luteum failure. Delineating the functional importance of an abrupt progesterone rise at the time of implantation may provide new strategies for promoting successful implantation in assisted reproduction. corpus luteum, corpus luteum function, human chorionic gonadotropin, pregnancy, progesterone

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Section: Introductionmentioning

confidence: 99%

Rescue of the Corpus Luteum in Human Pregnancy1

Baird

Weinberg

McConnaughey

et al. 2003

Biology of Reproduction

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“…During the luteal phase (i.e., following ovulation), the corpus luteum, formed from the ruptured follicle, is the principal source of P until about 5 weeks after conception, at which time placental production begins to predominate (16,17). During this initial period, either surgically removing the corpus luteum or biochemically blocking P with mefipristone leads to pregnancy failure (18,19).…”

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confidence: 99%

A prospective study of early pregnancy loss in humans

Vitzthum

Spielvogel

Thornburg

et al. 2006

Fertility and Sterility

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“…Hertz et al [4] found good correlations (90070) between the 24-h urinary PdG levels and the outcome of pregnancy. Mendizabad et al [9] found low levels of urinary PdG in women with apparent normal fetal development ultrasonographically but who later aborted. Recently, Davidson [2] recommended estimation of PdG for evaluation of threatened abortion.…”

Section: Discussionmentioning

confidence: 98%

Urinary estrone glucuronide, pregnanediol glucuronide and human chorionic gonadotrophin in threatened abortion

Ishwad

Chitlange

Joshi

et al. 1988

Intl J Gynecology & Obste

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Estimations of urinary estrone glucuronide, pregnanediol glucuronide and human chorionic gonadotrophin were carried out by ELISA to see their potential in predicting an abnormal outcome in cases with vaginal bleeding in early pregnancy. Reference values were set up with samples from women without bleeding in present or past pregnancies and with normal ultrasonic findings. None of the parameters were found to be sensitive enough to predict an abnormal outcome. However, predictability of an abnormal value was found to be 95% for estrone-3-glucuronide (E1G), 93% for pregnanediol glucuronide (PdG) and 87% for human chorionic gonadotrophin (hCG).

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Hormonal monitoring of early pregnancy by a direct radioimmunoassay of steroid glucuronides in first morning urine

Cited by 12 publications

References 15 publications

Rescue of the Corpus Luteum in Human Pregnancy1

Rescue of the Corpus Luteum in Human Pregnancy1

A prospective study of early pregnancy loss in humans

Urinary estrone glucuronide, pregnanediol glucuronide and human chorionic gonadotrophin in threatened abortion

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