Hormonal influence on antimicrobial peptide synthesis by fat body cells of a blowfly, Calliphora vicina R.-D. (Diptera, Calliphoridae)

Yakovlev, A. Yu.; Gordya, N. A.

doi:10.1134/s0013873813020024

Cited by 1 publication

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tyrosine decarboxylase, an enzyme catalysing the first decarboxylation step in the biosynthesis of tyramine and octopamine, is extremely important in the modulation of insect homeostasis during the stress response, including the modulation of insect metabolism and immune system functioning 56 , 122 . The decreased expression level of the TDC gene may lead to the inhibition of the immune response after Tenmo-TRP-7 administration because octopamine can enhance phagocytosis and AMP synthesis 123 , 124 . The importance of this observation is highlighted by the fact that one of the most representative GO terms was tyrosine metabolism process (Fig.…”

Section: Resultsmentioning

confidence: 99%

Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.

Urbański

Johnston

Bittermann

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Tachykinins (TKs) are a group of conserved neuropeptides. In insects, tachykinin-related peptides (TRPs) are important modulators of several functions such as nociception and lipid metabolism. Recently, it has become clear that TRPs also play a role in regulating the insect immune system. Here, we report a transcriptomic analysis of changes in the expression levels of immune-related genes in the storage pest Tenebrio molitor after treatment with Tenmo-TRP-7. We tested two concentrations (10–8 and 10–6 M) at two time points, 6 and 24 h post-injection. We found significant changes in the transcript levels of a wide spectrum of immune-related genes. Some changes were observed 6 h after the injection of Tenmo-TRP-7, especially in relation to its putative anti-apoptotic action. Interestingly, 24 h after the injection of 10–8 M Tenmo-TRP-7, most changes were related to the regulation of the cellular response. Applying 10–6 M Tenmo-TRP-7 resulted in the downregulation of genes associated with humoral responses. Injecting Tenmo-TRP-7 did not affect beetle survival but led to a reduction in haemolymph lysozyme-like antibacterial activity, consistent with the transcriptomic data. The results confirmed the immunomodulatory role of TRP and shed new light on the functional homology between TRPs and TKs.

show abstract