Hormonal Induction of Pseudopregnancy in Rats

Banik, U. K.; Ketchel, Melvin M.

doi:10.1530/jrf.0.0100085

Cited by 10 publications

(7 citation statements)

References 6 publications

(7 reference statements)

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“…Carlson & DeFeo (1965) showed that implantation may be induced in rats with severed pelvic nerves by an injection of reserpine. Banik & Ketchel (1965) and Mantalenakis & Ketchel (19666) have shown that implantation of transferred blastocysts occurs in rats in which pseudopregnancy was induced by daily injection of prolactin. It seems that prolactin can suppress the formation and release of follicle-stimulating hormone and luteinizing hormone as suggested by Rothchild (1960), but since the implantation of transferred blastocysts occurs promptly after the removal of the suckling young in post-partum pseudopregnant rats, there appears to be a release of gonadotrophin in response to the withdrawal of the litter.…”

Section: Discussionmentioning

confidence: 99%

Blastocyst Implantation During Post-Partum Pseudopregnancy in the Rat

Mantalenakis¹,

Ketchel²

1967

Journal of Endocrinology

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Five-day blastocysts were transferred to the uteri of rats during post \ x=req-\ partum pseudopregnancy. Low implantation rates were observed when blastocysts were transferred on days 5 to 11 of lactation pseudopregnancy to recipients which were suckling their litters. Two incidents of asynchronous implantation occurred. If the suckling young were removed at the time of blastocyst transfer, high rates of implantation were obtained. If the cervix of the recipients was electrically stimulated at the time of the post-partum oestrus, implantation, while delayed, occurred at a high rate even though the recipients were suckling their litters. These results suggest that the cervical stimulation which occurs at copulation is a requirement for implantation in normally mated lactating rats.

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Section: Discussionmentioning

confidence: 99%

Blastocyst Implantation During Post-Partum Pseudopregnancy in the Rat

Mantalenakis¹,

Ketchel²

1967

Journal of Endocrinology

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“…The definition of 'pseudopregnancy' used here is a persistence of such a smear for 9 or more days followed bya return to oestrus, and the resumption of regular cycles. Quotation marks are used because of the doubt that this period is truly equivalent to the state of pseudo-pregnancy induced by sterile coitus or mechanical stimulation of the uterine cervix, in terms of the ability of the uterus to form deciduomata or permit implantation of blastocysts (Banik & Ketchel, 1965).…”

Section: Methodsmentioning

confidence: 99%

The effects of a single injection of progesterone on the oestrous cycle, thyroid gland activity and uterus‐plasma concentration ratio for radio‐iodide in the rat

Brown-Grant¹

1967

The Journal of Physiology

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SUMMARY1. A single subcutaneous injection of 5 mg, 1-25 mg or 625 ,tg, but not 312 jtg, of progesterone in oil delayed ovulation in the rat by 1 or more days, when injected at the dioestrous stage of a 4-day oestrous cycle.2. When ovulation was delayed in this way the expected increase in the thyroid-serum concentration ratio for 1311 was also delayed but the ratio did increase when delayed ovulation occurred.3. A single injection of progesterone resulted in an increase in the uterusplasma and oviduct-plasma concentration ratios for 1311; the increase was greatest when steroid was injected at the dioestrous stage of the cycle and was delayed and least when the steroid was given at the pro-oestrous stage. 4. Ovulation was advanced by 1 day when progesterone was injected on the second day of dioestrus in rats showing regular 5-day cycles; this ovulation was not accompanied by an increase in the thyroid-serum concentration ratio. In these experiments a dose of progesterone that failed to advance ovulation produced a rise in uterus-plasma and oviductplasma ratio for 1311 but no rise was seen when ovulation was induced, suggesting that oestrogen secretion had been stimulated. 5. 20a-Dihydroprogesterone (pregn-4-en-20ax-ol-3-one) was not effective in delaying or advancing ovulation at a dose level of 2-5 mg per rat and had no effect on the uterus-plasma concentration ratio for radio-iodide.6. These results are discussed in relation to the hypothesis that the increase in thyroid gland activity at the oestrous stage of the cycle is related to the neuro-endocrine changes that lead to ovulation.

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“…Such a deteriorated CAR performance was also observed in pseu dopregnancy (PSP), which is a condition normally induced by the agency of reproductive hormones [Banik and Ketchel, 1965;Rothchild and Schubert, 1963]. Hence, it is tempting to assume that the sex hormones, particularly progesterone, could be involved in this attenuation of emotionality that possibly accounted for the sub sequent behavioural effects in both normal pregnancy and PSP.…”

Section: Discussionmentioning

confidence: 99%

Influence of Pseudopregnancy and Sex Hormones on Conditioned Behaviour in Rats

Banerjee¹

1971

Neuroendocrinology

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Performance of a prelearned conditioned avoidance response (CAR) showed gross deterioration in albino female rats during pregnancy and pseudopregnancy (PSP). To create a PSP-like condition, progesterone and oestradiol were given exogenously, singly and in combination, to different groups of rats. Progesterone alone caused a partial deterioration of behaviour; but when administered in combination with oestradiol, it produced effects on the CAR performance and body weight comparable to those observed in PSP. There was also a good correlation between the behavioural deficits and weight gains resulting from such treatment. Endogenous augmentation of the luteal hormones by prolactin administration in another group produced effects that were comparable to those seen in PSP, although quantitatively poorer. Progesterone, in conjunction with oestrogen, appeared to be responsible for the behavioural deteriorations in the female rats, but was ineffective in the males.

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Hormonal Induction of Pseudopregnancy in Rats

Cited by 10 publications

References 6 publications

Blastocyst Implantation During Post-Partum Pseudopregnancy in the Rat

Blastocyst Implantation During Post-Partum Pseudopregnancy in the Rat

The effects of a single injection of progesterone on the oestrous cycle, thyroid gland activity and uterus‐plasma concentration ratio for radio‐iodide in the rat

Influence of Pseudopregnancy and Sex Hormones on Conditioned Behaviour in Rats

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