Hormonal induction of endometrial receptivity

Paulson, Richard J.

doi:10.1016/j.fertnstert.2011.07.1097

Cited by 181 publications

(153 citation statements)

References 69 publications

(67 reference statements)

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“…Sator et al concluded that the novel progesterone aqueous formulation showed similar bioavailability as the reference oil-based product [24]. In these preliminary studies, it was demonstrated that the serum levels of P achieved with 25 mg were above the threshold necessary for pre-decidualization to occur [25,26]. In addition, an earlier phase II study [27] performed in 24 healthy subjects provided evidence that this aqueous progesterone administered SC at a daily dose of 25 or 50 mg was effective at priming the endometrial changes seen in the menstrual cycle in the absence of endogenous P. Because of no difference in the endometrial biopsies having been shown between the two doses tested, the lowest dose (25 mg/days, which corresponds to the physiologic amount produced by the ovary in the midluteal phase [28] was selected for the phase III trials of LPS in assisted reproduction technologies (ART).…”

Section: Discussionmentioning

confidence: 97%

Has ART Finally Got a Patient-Friendly Progesterone?

Allahbadia

2015

J Obstet Gynecol India

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Section: Discussionmentioning

confidence: 97%

Has ART Finally Got a Patient-Friendly Progesterone?

Allahbadia

2015

J Obstet Gynecol India

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“…Therefore, it is necessary to conduct randomized controlled studies in a prospective manner, which should also evaluate the above-mentioned factors. Intravaginal -----------------------------------100 or 200 mg 300 or 600 mg (daily) (14 ) (15-26) Intramuscular -----------------------------------50 mg 100 mg (daily) (14 ) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) …”

Section: Which Methods Is Preferable?mentioning

confidence: 99%

“…The administration of hCG to induce ovulation in a natural cycle (or modified natural cycle) has been reported to negatively affect the rates for ongoing pregnancies (14.3% vs 31.1%) (18). In natural or modified natural cycles, the embryo transfer is performed three to five days after ovulation, depending on when the embryos were frozen (19). Ovulation may occur unexpectedly while planning a natural cycle, which can lead to difficulties in adjusting the time of thawing and transferring the embryos.…”

Section: Embryo Transfer In a Natural (Spontaneous) Cyclementioning

confidence: 99%

Methods for endometrial preparation in frozen-thawed embryo transfer cycles

Kalem

Gürgan

2016

J Turkish German Gynecol Assoc

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Review 168 IntroductionFrozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. Another preferred practice to prevent multiple pregnancies in IVF cycles is to transfer a single embryo and freeze all surplus embryos (1). However, the best solution for endometrial preparation in these cycles is still a matter of debate (2). Frozen-thawed embryo transfer prevents embryo waste and increases the probability of pregnancy in a single stimulated cycle. Protocols applied in FT cycles aim for endometrial preparation only and are therefore simpler than complicated protocols that aim to develop many follicles. As the treatment for subfertility increases, so does the importance of FT embryo transfer; however, there is no consensus about which method is the best (3, 4). Pregnancy rates following FT embryo transfer have been found to be higher than those following fresh embryo transfer (5). Further, FT embryo transfer increases the cumulative pregnancy rate and decreases the cost; in addition, it is easy to perform and can be applied in a shorter time duration when compared to repetitive fresh embryo transfers (5). Using frozen excess embryos obtained as a result of the time-totime implementation of in vitro maturation (IVM) in patients with polycystic ovaries, successful pregnancies have been achieved (6). Therefore, studies have concentrated on factors affecting the success rate of FT embryo transfer cycles.Various cycle protocols are used for the preparation of the endometrium in an FT embryo transfer cycle. In one of these procedures, the transfer time is determined either by the natural course of a cycle [i.e., in an ovulatory patient exhibiting a natural (spontaneous) cycle] or by inducing ovulation during the course of a natural cycle. The second procedure involves the artificial preparation of the endometrium through the administration of exogenous estrogen and progesterone, which can be performed with or without the association of a gonadotropin-releasing hormone agonist. In the third procedure, the cycle is stimulated by gonadotropins and ovulation is induced by recombinant-human chorionic gonadotropin (rHcg) or hCG; however, this practice is no longer applied (7,8). Embryo transfer in a natural (spontaneous) cycleBoth embryo and endometrial development have to be synchronized in FT embryo transfer cycles in order to maximize the pregnancy rate (9). This synchronization can be achieved in several ways. The easiest is the endocrinological preparation of the endometrium during the natural cycle using the patient's own follicular sex steroids. In this application, the timing for embryo transfer (ET) is determined by either investigating the spontaneous luteinizing hormone (LH) surge or by the administration o...

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“…Oral progesterone route is ineffective, requiring high dosing, resulting in less active metabolites secondary to a hepatic first-pass effect [1, 8,[16][17][18]. Oral formulations appear to be clinically inferior for luteal support, whereas intramuscular and vaginal preparations lead to comparable rates of implantation and clinical pregnancy.…”

Section: Rationale For Vaginal Ringmentioning

confidence: 99%

Progesterone Vaginal Ring for Luteal Support

Stadtmauer

Waud

2014

J Obstet Gynecol India

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Progesterone supplementation is universally used and has been shown to be beneficial in supplementation of the luteal phase in IVF. There are multiple options and the most commonly used include intramuscular and vaginal progesterone. A progesterone vaginal ring is a novel system for luteal support with advantages of controlled release with less frequent dosing. This review examines options for progesterone luteal support focusing on the rationale for a progesterone vaginal ring. Pub-med search of the literature. A weekly vaginal ring, although not yet FDA approved, is an effective and safe alternative for luteal supplementation in IVF. Large prospective clinical trials are needed to determine the best protocols for replacement cycles.

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Hormonal induction of endometrial receptivity

Cited by 181 publications

References 69 publications

Has ART Finally Got a Patient-Friendly Progesterone?

Has ART Finally Got a Patient-Friendly Progesterone?

Methods for endometrial preparation in frozen-thawed embryo transfer cycles

Progesterone Vaginal Ring for Luteal Support

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