Hormonal Imbalance in Polycystic Ovarian Syndrome (Pcos) in Teaching Hospitals in Ekiti State, Nigeria

Oyebanji, Olufisayo G; Asaolu, M. F.; Amonimo, E. O.

doi:10.4236/ojog.2018.813147

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…In line with the report by Lv et al [26], estradiol levels in our study did not significantly differ between groups. However, this result disagreed with earlier findings by Ezeiruaka and Onitsha and Oyebanji et al [14,25]. The age range of the subjects in this study may account for this observed inconsistency.…”

Section: Resultscontrasting

confidence: 99%

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Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Akinola,

Inyangudo,

Ottun

et al. 2024

Cureus

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BackgroundPolycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by dyslipidemia, hormonal imbalances, and metabolic dysfunctions. Vitamin D deficiency may be implicated in the pathogenesis of PCOS, potentially exacerbating its metabolic syndrome. However, the exact interplay between these factors remains underexplored. AimThis study aimed to evaluate serum levels of vitamin D and its association with modalities of PCOS among women with PCOS and healthy controls. MethodsThis was a hospital-based case-control study where 60 women newly diagnosed with PCOS and 56 non-PCOS controls were consecutively recruited within a 10-month period. The women aged 20-40 were recruited at the gynecology clinics of Lagos State University Teaching Hospital and Lagos Island Maternity Hospital. PCOS was diagnosed using the Rotterdam's criteria. The biodata, anthropometry, clinical features, serum vitamin D, cortisol, progesterone, testosterone, estradiol, prolactin, anti-Mullerian hormone (AMH), thyroid-stimulating hormone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), insulin, fasting blood glucose (FBG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and very-low-density lipoprotein cholesterol (VLDL-C) levels of PCOS-diagnosed women were assessed and compared with those of women without PCOS. The exclusion criteria comprised known diabetics, women with gynecological pathologies such as fibroids, and women on medications affecting the study analytes or hormones. Statistical analyses included chi-square or Fisher's exact tests for categorical variables, student t-test for continuous variables, and Pearson's correlation for assessing relationships between continuous variables. The significance level was set at p<0.05 and a confidence interval of 95%. ResultsIndividuals with PCOS exhibited a younger mean age (26.90±3.73 versus 29.95±5.00 years, p=0.001) and a higher prevalence of irregular menstrual patterns (46.7% versus 14.3%, p=0.0001) and acne (58.3% versus 37.5%, p=0.025). Moreover, PCOS was associated with elevated levels of TC (p = 0.03), TG (p = 0.03), LDL-C (p = 0.014), FBG (p = 0.001), LH:FSH ratio (p = 0.002), AMH (p = 0.0001), and testosterone (p = 0.003), but low progesterone (p = 0.001) and vitamin D (p = 0.033), alongside a higher incidence of vitamin D deficiency (33.3% versus 26.1%) and insufficiency (66.7% versus 56.5%). Additionally, significant but weak correlations were observed between serum vitamin D levels and waist-hip ratio (r = 0.4, p = 0.016) and FBG (r = -0.4, p = 0.036) in the PCOS group, suggesting potential metabolic implications. ConclusionThe PCOS subjects in this study had decreased vitamin D and progesterone levels, with elevated concentrations of testosterone, AMH, lipid profile (TC, LDL, and TG), FBG, and LH:FSH ratio. Studies on the therapeutic effect of vitamin D administration in managing PCOS will need to be further evaluated.

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Section: Resultscontrasting

confidence: 99%

“…This observed hyperandrogenism was in accordance with earlier studies by Ezeiruaka and Onitsha [14] and Oladoso et al [23]. Conversely, serum progesterone levels consistent with previous studies [14,25] were significantly lower in the PCOS group, indicating potential ovulatory dysfunction.…”

Section: Resultssupporting

confidence: 93%

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Akinola,

Inyangudo,

Ottun

et al. 2024

Cureus

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“…[ 45 ] Oyebanji et al . [ 46 ] showed that PCOS women have higher levels of total testosterone, oestrogen and the LH/FSH ratio compared to non-PCOS. These hormones are expected to play a role in uric acid regulation, but the mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Association between Polycystic Ovarian Syndrome, Impaired Kidney Function and Hyperuricaemia: A Systematic Review and Meta-analysis

Widjanarko,

Iskandar,

Suryatenggara

et al. 2024

Journal of Human Reproductive Sciences

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Background: Polycystic ovarian syndrome (PCOS) is a gynaecological problem affecting women within reproductive age, accompanied by several metabolic anomalies, thus leading to alteration in kidney function and hyperuricaemia. Due to the high prevalence of cardiometabolic factors in PCOS, there is a need to anticipate an increased number of kidney impairments amongst these women. Objectives: This review aims to investigate the potential link between PCOS, impaired kidney function, and elevated uric acid levels. By elucidating this association, we hope to provide clinicians with a tool to stratify the risk of kidney disease in women diagnosed with PCOS, based on readily available kidney function parameters. Materials and Methods: The recommendations used for the analysis were outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Subsequently, eligible studies were identified using several databases (MEDLINE, ProQuest and EBSCOhost) between 1996 and 2022, with a total of 13 studies included. Serum uric acid, serum creatinine, as well as estimated glomerular filtration rate (eGFR) were evaluated as the outcome of interest. Quality assessment for cohort, case–control and cross-sectional studies was conducted utilising the Newcastle–Ottawa Scale, while Review Manager 5.4 was utilised for meta-analysis. Results: Uric acid was significantly higher in women with PCOS (mean difference [MD] = 0.70, 95% confidence interval [CI] [0.45–0.95], P < 0.00001). Meanwhile, serum creatinine and eGFR were statistically similar in each group (MD = 0.08, 95% CI [−0.05–0.21], P = 0.22 and MD = 3.54, 95% CI [−4.53–11.61], P = 0.39, respectively). Interpretation: This review showed that PCOS was significantly associated with elevated uric acid. However, no significant difference was found between eGFR and creatinine levels compared to healthy controls. Routine uric acid assessment in PCOS patients is recommended as a simple tool for risk stratification. Limitations: No body mass index (BMI) subgroup analysis was done due to limited BMI reporting in our included studies. Quantitative analysis of all kidney function parameters was also limited by sparse data on urea and albumin. PROSPERO Registration Number: CRD42023410092 (02 April 2023).

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“…Stimulation of EV causes a decrease in follicle-stimulating hormone hormones and their transformation into large follicles in ovarian morphology, such as cysts with atresia. While estradiol is the main female sex hormone controlling female reproduction during estrus and menstruation, high estrogen levels in the body can cause PCOS ( Oyebanji et al , 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of renal disturbance in animal models of polycystic ovary syndrome

Oktanella,

Untari,

Wuragil

et al. 2023

Open Vet J

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Background: Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by hyperandrogenism, hyperinsulinemia, followed by luteinizing hormone (LH) and follicle stimulating hormone (FSH) deficiency. PCOS conditions cause metabolic disorders that increase uric acid levels and malondialdehyde levels. Animal models of PCOS have been used extensively in research to study the pathogenesis, clinical characteristics and treatment of PCOS. Aim: This study aimed to identify the pathological mechanisms underlying renal dysfunction in PCOS by observing several parameters, including BUN, creatinine, uric acid, and renal MDA levels. Methods: This research was an experimental designed study using Wistar rat (Rattus norvegicus) as animal model of PCOS which were divided into three groups: negative control (CN) group (n=6), Testosterone propionate induction group (n=6), and estradiol valerate induction group (n=6). Results: According to statistical analysis it indicated that induction of TP and EV can increase blood uric acid levels in PCOS model rats (p<0.05), TP induction can increase kidney BUN and MDA levels significantly (p<0.05), However, the observation of creatinine levels did not show significant differences in all treatment groups (p>0.05). Conclusion: Based on the results of this study, it can be concluded that the induction of animal models with testosterone propionate can trigger a significant renal damage compared to estradiol valerate.

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Hormonal Imbalance in Polycystic Ovarian Syndrome (Pcos) in Teaching Hospitals in Ekiti State, Nigeria

Cited by 4 publications

References 21 publications

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Association between Polycystic Ovarian Syndrome, Impaired Kidney Function and Hyperuricaemia: A Systematic Review and Meta-analysis

Evaluation of renal disturbance in animal models of polycystic ovary syndrome

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