Hormonal homeostasis in a group of 216 aging Czech males and correlation with responses to a questionnaire of the University of St Louis

Miroslav, Hanuš; Matoušková, Michaela; Stárka, L.; Hill, Martin

doi:10.1080/13685530600624150

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…In line with our study, other studies [14,15] have failed to identify a connection between LOH symptoms and circulating androgen levels. It is likely that symptoms associated with LOH have a complex background and are not caused simply by partial androgen deficiency.…”

Section: Partial Androgen Deficiency In Aging Males (Padam) or Androgsupporting

confidence: 81%

Symptoms of testosterone deficiency in early middle aged men

Holm¹,

Fredrikson²,

Hammar³

2012

The Aging Male

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Symptoms of testosterone deficiency and concentrations of testosterone (T) and bioavailable testosterone (BT) were studied in 35-and 45-year-old men. Methods: A questionnaire, was sent to all 35-and 45-year-old men in Linkoping, Sweden (n = 1998). The questionnaire has earlier been used for 55- to 75-year-old men and included demographic data, medical history, different symptoms possibly of T deficiency and the 10 questions from the "ADAM-questionnaire". Totally 200 men randomly selected among the men who answered the questionnaire were asked to give blood samples for analysis of T-and BT-concentrations. Results: A total of 38.7% of the questionnaires were returned and analysed, and 43.5% of the 200 randomly selected men gave blood samples. The older age group reported more symptoms that may be connected to low B and BT and had lower T-and BT-concentrations. Less strong erections and higher alcohol consumption were associated with lower concentrations of BT in 45-year-old men. Conclusions: The burden of symptoms possibly related to low T concentrations were higher in 45-year-old men, and BT and T were lower. However, due to the low answer frequency and number of blood samples analyzed no general conclusions can be drawn

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Section: Partial Androgen Deficiency In Aging Males (Padam) or Androgsupporting

confidence: 81%

Symptoms of testosterone deficiency in early middle aged men

Holm¹,

Fredrikson²,

Hammar³

2012

The Aging Male

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“…Various possible metabolic markers and mechanisms are also investigated, for instance by the team of the Department of Gerontology and Metabolism, Medical Faculty and Teaching Hospital Hradec Králové. The topic of male ageing is also explored by several teams (Hanus et al 2006;Stárka 2003). Some other research institutes focus on different organ systems, e.g.…”

Section: Biogerontology In the Czech Republicmentioning

confidence: 99%

Biogerontology in the Czech Republic

Holmerová¹,

Vaňková²,

Jurašková

2010

Biogerontology

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Authors provide results of their review of research in the field of biogerontology. Despite the fact that the term "biogerontology" is not commonly used in Czech scientific practice, there have been many research efforts in this field. Up to present, the Czech research teams have focused on the theoretical and biological models of ageing, its immunological aspects, the risk factors of unsuccessfull human ageing, and also metabolic and nutritional factors. Many research teams are dealing with the mechanisms of the neurodegeneration. The authors conclude that better coordination and systematic funding of research in gerontology is needed because of the actual demographic challenges.

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“…Also in line with previous reports [9], 4.5% of men reported hot flushes, which is why we suggest that hot flushes should be regarded as a possible LOH symptom. There are also other studies [10,11] that have failed to identify a connection between LOH symptoms and circulating androgen levels. To monitor changes in LOH symptoms as well as androgens, we used the same cross-sectional study design as in 2003 in the same cohort of men but five years later.…”

Section: Introductionmentioning

confidence: 99%

Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism

Holm

Fredrikson²,

Theodorsson

et al. 2011

The Aging Male

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Symptoms of Late onset Hypogonadism (LOH) and concentrations of Testosterone (T) andBioavailable Testosterone (BT) were studied in relation to the data from the same men five years earlier. Methods:In 2008, 282 men, 60-82 years answered a questionnaire regarding demographic data, medical history, different symptoms of LOH and the 10 questions from the "ADAM-questionnaire".Blood samples were analysed for concentrations of T and calculations were made for BT.Results: 87.2% of the questionnaires were returned and analysed, and 75.2% of the responders gave blood samples. The oldest third of the men were most affected by LOH symptoms (p<0.05). Both T and BT-concentrations decreased during the five years (p<0.05) but only the symptom "less strong erections" changed significantly (p<0.05). Men reporting one of four specific symptoms from the "ADAM-questionnaire" for the first time in 2008 had a higher loss of T and BT than men who had unchanged or fewer symptoms than reported in 2003. Conclusions:The magnitude of the decrease in concentrations is a better predictor of LOH than are the actual concentrations of T and or BT. A combination of symptoms predicts LOH better than any single symptom.

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Hormonal homeostasis in a group of 216 aging Czech males and correlation with responses to a questionnaire of the University of St Louis

Cited by 8 publications

References 29 publications

Symptoms of testosterone deficiency in early middle aged men

Symptoms of testosterone deficiency in early middle aged men

Biogerontology in the Czech Republic

Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism

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