HORMONAL FACTORS INFLUENCING FAT DEPOSITION IN THE INTERSCAPULAR BROWN ADIPOSE TISSUE OF THE WHITE RAT<sup>1</sup>

Lachance, Jean-Paul; Pagé, Edouard

doi:10.1210/endo-52-1-57

Cited by 100 publications

(8 citation statements)

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“…The present evidence indicates that melatonin acts directly on BAT to cause the above-mentioned increase in weight. Administration of either thyroxine or adrenal glucocorticoids stimulates growth of BAT (Lachance, 1953 ;LaChance & PagC, 1952), an effect similar to that elicited by melatonin. Yet melatonin has been shown to inhibit both the thyroid and the adrenal (see above).…”

Section: Brown Adipose Tissuementioning

confidence: 95%

The Pineal Complex and Thermoregulation

et al. 1979

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Section: Brown Adipose Tissuementioning

confidence: 95%

The Pineal Complex and Thermoregulation

et al. 1979

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“…Finally, a more proximate involvement of corticosterone cannot be excluded. It has long been known that corticosterone treatment stimulates lipogenesis and glycogenesis in brown adipose tissue (Lachance & Page, 1953) and corticosteroid receptors are present in this tissue. In addition, corticosteroids may regulate /3-adrenoreceptor number and affinity in the rat (Hedburg, 1983) again raising the possibility that part of the response involves catecholamine-mediated events.…”

Section: Discussionmentioning

confidence: 99%

The effect of catabolic doses of corticosterone on heat production in the growing rat

Coyer¹,

Cox²,

Rivers³

et al. 1985

Br J Nutr

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1. The effect of corticosterone treatment on energy balance and heat production was investigated in growing rats. Animals were treated with daily subcutaneous injections of a vehicle containing 0, 50 or 100 mg corticosterone/kg for 5 d.2. Measurements of digestible energy intake and urinary energy losses showed that corticosterone treatment resulted in a depression of metabolizable energy intake due to elevated urinary energy losses resulting from massive glucosuria.3. Measurements of the metabolizable energy intake and the change in carcass energy indicated that at 50 mg/kg energy deposition and heat production were reduced, whilst at 100 mg/kg energy deposition was completely abolished with heat production increased. Postprandial oxygen consumption was unchanged at 50 mg/kg and increased at 100 mg/kg.4. Factorial analysis of these results based on reported values for the energy cost of protein and fat deposition indicated that (a) the depression of total heat production at 50 mg/kg could be entirely accounted for by the concomitant suppression of growth, and (b) the elevation of total and postprandial heat production at 100 mg/kg reflected a specific influence of corticosterone on thermogenesis.5. The significance of these findings is discussed in the light of reports that corticosterone in low doses suppresses heat production.

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“…However, simultaneous stimulation of the conversion of cholesterol into bile acids [158] and the elimination of cholesterol from the body [505] provide an explanation for this observation. Thyroxine increases the deposition of fat in the brown adipose tissue of rats, acting in this respect synergistically with cortisone [361]. However, it is not yet proved whether lipid synthesis is increased under these conditions.…”

Section: Metabolismmentioning

confidence: 99%

Physiological Effects of the Thyroid Hormones

et al. 1975

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The thyroid gland has a powerful influence over the activities of the whole body. If the function of the gland is for any reason lost, serious disturbances of chemical and morphological structure arise and are manifested as physical and mental disorders. The diversity of the action of thyroid hormones on physiological functions, on the metabolic rate, and on the activity of various enzyme systems both in the body as a whole and in tissue preparations has been known for a long time. Our knowledge of the role of thyroid hormones is based on experiments in which a particular thyroid hormone has been given to healthy and athyrotic animals and on extensive clinical observations on patients with hyperthyroid and hypothyroid states.The effect of thyroid hormones in vivo is expressed as reactions of whole organs and of individual physiological functions and morphological structures. The internal secretions of the thyroid gland modify growth and metamorphosis, the utilization of oxygen by the body as a whole or by tissue preparations in vitro, various aspects of metabolism, and the activity of particular enzyme systems.The extreme diversity of the effects observed after injection of thyroid hormone may reflect the primary action of this agent on a single link fundamental to the mechanism of biochemical processes in the cell or on a single morphological structure responsible for the proper integration of processes at the cell level. These problems will be examined fully later. Here I shall merely state that when the action of a thyroid hormone is discussed, the term is used not only with respect to the thyroxine and triiodothyronine produced in the thyroid gland, but also to several of their derivatives and analogs. However, we know that all compounds with the biological activity 125 Y. K. Turakulov et al., Thyroid Hormones

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HORMONAL FACTORS INFLUENCING FAT DEPOSITION IN THE INTERSCAPULAR BROWN ADIPOSE TISSUE OF THE WHITE RAT¹

Cited by 100 publications

References 0 publications

The Pineal Complex and Thermoregulation

The Pineal Complex and Thermoregulation

The effect of catabolic doses of corticosterone on heat production in the growing rat

Physiological Effects of the Thyroid Hormones

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HORMONAL FACTORS INFLUENCING FAT DEPOSITION IN THE INTERSCAPULAR BROWN ADIPOSE TISSUE OF THE WHITE RAT1

Cited by 100 publications

References 0 publications

The Pineal Complex and Thermoregulation

The Pineal Complex and Thermoregulation

The effect of catabolic doses of corticosterone on heat production in the growing rat

Physiological Effects of the Thyroid Hormones

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Product

Resources

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HORMONAL FACTORS INFLUENCING FAT DEPOSITION IN THE INTERSCAPULAR BROWN ADIPOSE TISSUE OF THE WHITE RAT¹