Hormonal Factors Influencing Erythropoiesis

Dyke, Donald C. Van; Contopoulos, A. N.; Williams, B. S.; Simpson, Miriam E.; Lawrence, John H.; Evans, Herbert M.

doi:10.1159/000204551

Cited by 80 publications

(13 citation statements)

References 1 publication

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“…per 100 gln. of body weight, to 2.18 ml., a level identical with that found in normal rats (68). It may be further noted that the erythropoietic activity of the hormone increases with the dosage, reaching a maximum at a daily dose of 25 #g. There appears to be some indication of an inhibition of this increment in red cell volume at the higher dose levels.…”

Section: Discussionsupporting

confidence: 69%

Corticotropins (Acth)

Fønss-Bech

Geschwind

et al. 1957

The Journal of Experimental Medicine

109

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The isolation and structure of a-corticotropin, a polypeptide of 39 amino acid residues, derived from sheep pituitary glands and possessing an adrenocorticotropic (ACTH) activity of 150 I.V. per rag., have been reported from this laboratory (1-3). The present paper is concerned with various biological properties of the peptide hormone. A. Stimulation of the Adrenal Glands in Normal and Hypopkysectomized RatsExperiments witk Normal Rats.--The increment of adrenal weight in 21-dayold normal male rats induced by the administration of ACTH preparations has been suggested by Moon (4) as a criterion for the assay of ACTH potency. Because various substances and conditions will produce adrenal hypertrophy in the intact animal, this criterion is not specific, and hence, as has been discussed elsewhere (5), this type of assay does not furnish a reliable index of degree of biological potency. It is, however, useful for detecting activity in a preparation, since adrenocorticotropicaUy active preparations should be capable of increasing the adrenal weight in normal animals.The hormone peptide was suspended in peanut oil and S per cent beeswax according to the procedure described by Bruce, Parkes, and Perry (6). Male rats, 28 days of age, of the Long-Evans strain were injected intraperltoneally with 0.1 ml. of the hormone suspension once daily for 4 days, and the --|reals were autopsied 24 hours after the last injection. As Table I reveals, 1 a daily dose of 1S/zg of a-corticotropin for 4 days produced an increase in * Present address:

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Section: Discussionsupporting

confidence: 69%

Corticotropins (Acth)

Fønss-Bech

Geschwind

et al. 1957

The Journal of Experimental Medicine

109

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“…Anaemia is also described in patients suff ering from Addison disease leading to a decrease of steroid hormones [10]. Th is is further corroborated by evidence from experimental adrenalectomy in animals that resulted in anaemia [11,12].…”

Section: Discussionmentioning

confidence: 96%

An uncommon cause of anaemia: Sheehan's syndrome

Melchardt¹,

Namberger²,

Weiß³

et al. 2010

Wien Klin Wochenschr

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Ischemic pituitary necrosis due to severe postpartum haemorrhage called Sheehan's syndrome is a rare cause of hypopituitarism in the western world, but much more common in developing countries. A 45-year-old female patient being a war refugee from Chechnya with severe anaemia and fatigue was diagnosed at our outpatient department with Sheehan's syndrome after severe postpartum haemorrhage and emergency hysterectomy 15 years ago. Panhypopituitarism was adequately treated with substitution of hydrocortisone, thyroxine and transdermal oestrogen which resulted in haemoglobin increase to nearly normal levels and symptoms improved immediately. Severe anaemia caused by panhypopituitarism shows the importance of the hormonal system for erythropoiesis. Clinical and basic scientific evidence indicates thyroidal hormones to be the main cause.

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“…Thus, estrogens induce anemia in normal and castrated animals (9,15,(28)(29)(30) and intensify the post-hypophysectomy anemia in rats (9). Along the same lines, administration of gonadotrophin (PMS) induces anemia TABLE 6.…”

Section: Discussionmentioning

confidence: 95%

Mechanism of Estrogen Action in Erythropoiesis

Mirand

Gordon

1966

Endocrinology

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Whereas plasma from mice, rats and tamarins subjected to hypoxia significantly augmented erythropoiesis Fe incorporation values) in transfusioninduced plethoric mice, plasma from animals injected with estradiol cyclopentylpropionate (ECP) before exposure to hypoxia lacked this capacity. The ability of ECP to counteract the erythropoiesis-stimulating action of hypoxia was not due to the presence of residual biologically active estrogen in the plasma. That it was also not attributable to other blood-borne erythropoiesis-inhibiting agents evoked by the estrogen was evident because plasma from ECP-treated mice failed to 1) depress erythropoiesis in normal mice, 2) prevent the production of the erythropoiesisstimulating factor (ESF) in plethoric mice exposed to hypoxia, and 3) antagonize the erythropoietic action of exogenous ESF. The conclusion drawn is that estrogen inhibits the production of the ESF. It was further shown that, whereas the stimulatory action of androgen (testosterone cyclopentylpropionate) on erythropoiesis required the presence of the kidneys, the erythropoiesis-inhibiting effects of estrogen were evident in nephrectomized as well as in intact mice. It is suggested that estrogens inhibit erythropoiesis by suppressing the production of an extrarenal precursor of ESF which requires activation by a kidney mechanism for elaboration of the functional circulating ESF. (Endocrinology 78: 325, 1966)

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Hormonal Factors Influencing Erythropoiesis

Cited by 80 publications

References 1 publication

Corticotropins (Acth)

Corticotropins (Acth)

An uncommon cause of anaemia: Sheehan's syndrome

Mechanism of Estrogen Action in Erythropoiesis

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