Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study

Custer, Brian; Longstreth, W. T.; Phillips, Lorraine J.; Koepsell, Thomas D.; Belle, Gerald van

doi:10.1186/1471-2407-6-152

Cited by 120 publications

(158 citation statements)

References 30 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…In addition, as in this study, previous studies have found no association between oral contraceptive use and meningioma or glioma risk (Jhawar et al, 2003;Custer et al, 2006;Wigertz et al, 2006).…”

Section: Discussionsupporting

confidence: 65%

Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

et al. 2008

View full text Add to dashboard Cite

Previous studies have reported inconsistent results on the effect of anthropometric and lifestyle factors on the risk of developing glioma or meningioma tumours. A prospective cohort of 1.3 million middle-aged women was used to examine these relationships. During 7.7 million women-years of follow-up, a total of 1563 women were diagnosed with a primary incident central nervous system tumour: 646 tumours were classified as glioma and 390 as meningioma. Our results show that height is related to the incidence of all central nervous system tumours with a risk of about 20% per 10 cm increase in height (relative risk ¼ 1.19, 95% CI ¼ 1.10 -1.30 per 10 cm increase in height, Po0.001): the risks did not differ significantly between specified glioma and meningioma. Body mass index (BMI) was also related to central nervous system tumour incidence, with a risk of about 20% per 10 kg m À2 increase in BMI (relative risk ¼ 1.17, 95% CI ¼ 1.03 -1.34 per 10 kg m À2 increase in BMI, P ¼ 0.02). Smoking status, alcohol intake, socioeconomic level, parity, age at first birth, and oral contraceptive use were not associated with the risk of glioma or meningioma tumours. In conclusion, for women in the United Kingdom, the incidence of glioma or meningioma tumours increases with increasing height and increasing BMI. British Journal of Cancer (2008) Keywords: body mass index; glioma; height; meningioma; women Primary brain and central nervous system cancers are relatively rare and represent approximately 2% of all cancers diagnosed in the United Kingdom. However, due to a poor prognosis, they are responsible for 7% of the years of life lost from cancer before the age of 70 years (Cancer Research UK, 2007). Very little is known about the aetiology of central nervous system tumours, but environmental factors are thought to play a role (McKinney, 2004;Connelly and Malkin, 2007).The two most common types of central nervous system tumour are glioma and meningioma (Claus et al, 2005). Gliomas arise from glial cells, are found predominantly in the brain and to a lesser extent in the spinal cord or other parts of the central nervous system, and represent more than 70% of all brain tumours (Ohgaki and Kleihues, 2005). Gliomas are typically histologically malignant, can be either slow or fast growing, and are more frequently diagnosed in men than in women. Meningiomas arise from the arachnoidal cells of the leptomeninges (the pia mater and arachnoid mater of the meninges) (Sanson and Cornu, 2000), are also more frequently found in the brain than elsewhere in the central nervous system, and represent more than 20% of all brain tumours (Longstreth et al, 1993). Meningiomas are typically benign (490%) and slow growing. The risk of meningioma increases with age (Sanson and Cornu, 2000), and they are more frequently diagnosed in women (Sanson and Cornu, 2000;Perry et al, 2007).There are few well-established risk factors for glioma and meningioma tumours among adults; while exposure to ionizing radiation and rare inherited genetic conditions such as n...

show abstract

Section: Discussionsupporting

confidence: 65%

Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Because little is known of the etiology of brain tumors and current knowledge of how reproductive factors influence the risk is conflicting (12,13,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), we conducted an international population-based case-control study to investigate how reproductive history affects the risk of glioma and meningioma. Brain tumor growth and especially the growth of meningiomas has been reported to be related to pregnancy (28); therefore, we decided to investigate if the relations between pregnancy related factors and brain tumor risk differed between young (fertile ages) and older women.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Factors and Risk of Meningioma and Glioma

Wigertz¹,

Lönn

Hall

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Female sex hormones have previously been suggested as possible risk factors for brain tumors, but published studies have reported conflicting results. We conducted a population-based case-control study of glioma (n = 626) and meningioma (n = 906) cases and randomly selected controls stratified on age and geographic region (n = 1,774) in Denmark, Finland, Norway, Sweden, and the United Kingdom. Unconditional logistic regression was used to estimate odds ratios (OR) for glioma and meningioma in relation to reproductive factors. A decreased glioma risk was associated with ever-pregnancy compared with neverpregnancy [OR, 0.8; 95% confidence interval (95% CI), 0.6-1.0]. Meningioma risk among women ages <50 years was increased in relation to number of pregnancies leading to a live birth (OR, 1.8; 95% CI: 1.1-2.8 for giving birth to 3 children compared with nulliparous women; P trend among parous women = 0.01). This relation was not found for older women. Breastfeeding among parous women increased the glioma risk (OR, 2.2; 95% CI, 1.3-3.9 for breast-feeding 36 months or more compared with breast-feeding 3 months or less). Menopausal status and age at menopause were not associated with meningioma or glioma risk. Our findings imply that reproductive hormones may influence the occurrence of meningioma and glioma.

show abstract

“…Issues that might be examined include the criteria for inclusion in analyses, the definitions of exposures or outcomes,79 which confounding variables merit adjustment, the handling of missing data,80, 81 possible selection bias or bias from inaccurate or inconsistent measurement of exposure, disease and other variables, and specific analysis choices, such as the treatment of quantitative variables (see item 11). Sophisticated methods are used increasingly to simultaneously model the influence of several biases or assumptions82, 83, 84 …”

Section: (E) Describe Any Analyses Used To Assess the Robustness Ofmentioning

confidence: 99%

Explanation and Elaboration Document for the STROBE‐Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary Extension

O’Connor

Sargeant

Dohoo

et al. 2016

Veterinary Internal Medicne

View full text Add to dashboard Cite

The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement was first published in 2007 and again in 2014. The purpose of the original STROBE was to provide guidance for authors, reviewers, and editors to improve the comprehensiveness of reporting; however, STROBE has a unique focus on observational studies. Although much of the guidance provided by the original STROBE document is directly applicable, it was deemed useful to map those statements to veterinary concepts, provide veterinary examples, and highlight unique aspects of reporting in veterinary observational studies. Here, we present the examples and explanations for the checklist items included in the STROBE‐Vet statement. Thus, this is a companion document to the STROBE‐Vet statement methods and process document (JVIM_14575 “Methods and Processes of Developing the Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary (STROBE‐Vet) Statement” undergoing proofing), which describes the checklist and how it was developed.

show abstract

Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study

Abstract: Background: The role of exogenous hormone exposures in the development of meningioma is unclear, but these exposures have been proposed as one hypothesis to explain the over-abundance of such tumors in women.

Cited by 120 publications

References 30 publications

Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

Reproductive Factors and Risk of Meningioma and Glioma

Explanation and Elaboration Document for the STROBE‐Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary Extension

Contact Info

Product

Resources

About