Hormonal Differences Between Female Kidney Transplant Recipients and Healthy Women With the Same Gynecologic Conditions

Kim, J.M.; Song, Reem; Kim, M.-J.; Lee, D.Y.; Jang, Hye-Ryoun; Kwon, Choon Hyuck David; Huh, Woo Seong; Kim, G.S.; Kim, Seung Ju; Choi, Doo Seok; Joh, Jae‐Won; Lee, S.-K.; Oh, Hayoung

doi:10.1016/j.transproceed.2011.12.072

Cited by 10 publications

(14 citation statements)

References 12 publications

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“…It is postulated that this may partly be due to an increase in irregular menses and menorrhagia after kidney transplantation compared to prior [ 17 ]. This abnormal bleeding may be associated with changes to the hormonal profile post-transplantation [ 18 ]. However, we did not have data on menopausal status to address this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with anaemia in kidney transplant recipients in the first year after transplantation: a cross-sectional study

2018

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BackgroundAnaemia after kidney transplantation may reduce quality of life, graft or patient survival. We aimed to determine the prevalence and risk factors for anaemia in the initial 12 months after transplantation.MethodsWe conducted a cross-sectional study at 6 and 12 months after transplantation. Anaemia was defined by World Health Organization criteria taking into consideration erythropoietin use. Logistic regression was used to determine the association between demographic, clinical and pharmacological risk factors for the main outcome of moderate-severe anaemia.ResultsA total of 336 transplant recipients were included and the prevalence of moderate-severe anaemia was 27.4% at 6 months and 15.2% at 12 months. Lower kidney function, female gender, transferrin saturation below 10% and proteinuria were associated with moderate-severe anaemia at both time points. Recent intravenous immunoglobulin treatment was associated with anaemia at 6 months. Recent infection and acute rejection were also associated with anaemia 12 months. Around 20% of patients had at least one blood transfusion but they were uncommon beyond 3 months.ConclusionsAnaemia remains highly prevalent requiring treatment with erythropoietin and transfusions. Most identifiable risk factors relate to clinical problems rather than pharmacological management, while markers of iron-deficiency remain difficult to interpret in this setting.Electronic supplementary materialThe online version of this article (10.1186/s12882-018-1054-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Factors associated with anaemia in kidney transplant recipients in the first year after transplantation: a cross-sectional study

2018

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“…Some hormonal disturbances can be corrected by normalization of the serum PRL level through improving renal replacement therapy such as nocturnal hemodialysis (NHD) or renal transplantation (RT) [ 10 , 11 ]. Despite successful RT, in previous studies [ 12 , 13 ], menstrual disturbances were commonly seen in premenopausal women with ESRD. Thus, the role and effects of RT on menstrual cycle remodeling in premenopausal women with ESRD remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Menstrual Disturbances in Premenopausal Women with End-Stage Renal Disease: A Cross-Sectional Study

Lin

Liu

et al. 2016

Med Princ Pract

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Objective: To evaluate menstrual disturbances and sex hormonal status in premenopausal women with end-stage renal disease (ESRD). Subjects and Methods: The study consisted of 184 patients with ESRD treated with one of four treatment modalities (46/modality): conventional hemodialysis (CHD), continuous ambulatory peritoneal dialysis (CAPD), nocturnal hemodialysis (NHD) and renal transplantation (RT). Blood samples were collected to determine sex hormone levels. Sociodemographic and clinical data were collected from medical records. A questionnaire was administered to analyze menstrual patterns, and the final analysis included 46, 43, 40 and 36 patients in the CHD, CAPD, NHD and RT groups, respectively. Results: The overall prevalence of menstrual disturbances was 64.2% for all four treatment modalities (RT: 50%; NHD: 55%; CAPD: 72.1%, and CHD: 76.1%). Serum prolactin levels were significantly lower (p < 0.01) in the NHD (25.1 ± 10.9 ng/ml) and RT (13.4 ± 5.1 ng/ml) groups than in the CHD group (55.2 ± 10.8 ng/ml). Serum progesterone levels were significantly higher (p < 0.01) in the NHD (25.7 ± 8.3 nmol/l) and RT (30.1 ± 5.9 nmol/l) groups than in the CHD group (17.7 ± 7.3 nmol/l). Moreover, the hormonal status (follicle-stimulating hormone, luteinizing hormone and testosterone) was much closer to normal in the NHD and RT groups compared to the other two groups. Conclusions: In this study, successful transplantation and NHD partially improved the symptoms of menstrual disturbances. Therefore, we recommend that further studies are necessary to confirm our finding in ESRD patients.

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“…Comparable research was performed on grafted women and the same trend of hypothalamic-pituitary-gonadal axis disturbances were visible [19]. Inversed results were observed by Kim et al [18], which might be related to a different immunosuppressive regimen that was applied. Surprisingly, approximately five years after transplantation, the concentration of E2 in grafted women of reproductive age was not established to its level in the healthy control.…”

Section: Renal Transplant Recipients Vs Ckd/dialyzed Patientsmentioning

confidence: 89%

Hormonal (Im)Balance and Reproductive System’s Disorders in Transplant Recipients—A Review

Szypulska-Koziarska

Misiakiewicz-Has

Wiszniewska

2021

Biology

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The rising need for treatment of end stage of organ failure results in an increased number of graft recipients yearly. The most commonly transplanted organs are kidney, heart, liver, bone marrow, lung and skin. The procedure of transplantation saves and prolongs the lives of chronically ill patients or at least improves the quality. However, following transplantation recipients must take immunosuppressive drugs on a daily basis. Usually, the immunosuppressive therapy comprises two or three drugs from different groups, as the mechanism of their action varies. Although the benefits of intake of immunosuppressants is undeniable, numerous side effects are associated with them. To different extents, they are neurotoxic, nephrotoxic and may influence the function of the reproductive system. Nowadays, when infertility is an urgent problem even among healthy pairs, transplant recipients face the problem of disturbance in the hypothalamic−pituitary axis. This review will provide an overview of the most common disturbances among the concentration of sex-related hormones in recipients of both sexes at different ages, including sexually immature children, adults of reproductive age as well as elderly women and men. We have also focused on the numerous side effects of immunosuppressive therapy regarding function and morphology of reproductive organs both in males and females. The current review also presents the regimen of immunosuppressive therapy and time since transplantation.

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Hormonal Differences Between Female Kidney Transplant Recipients and Healthy Women With the Same Gynecologic Conditions

Cited by 10 publications

References 12 publications

Factors associated with anaemia in kidney transplant recipients in the first year after transplantation: a cross-sectional study

Factors associated with anaemia in kidney transplant recipients in the first year after transplantation: a cross-sectional study

Menstrual Disturbances in Premenopausal Women with End-Stage Renal Disease: A Cross-Sectional Study

Hormonal (Im)Balance and Reproductive System’s Disorders in Transplant Recipients—A Review

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