Hormonal Control of Ca Homeostasis in Lower Vertebrates: Considering the Evolution

Sasayama, Yuichi

doi:10.2108/zsj.16.857

Cited by 31 publications

(17 citation statements)

References 95 publications

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“…The tree also indicates that the rainbow trout sCT precursors are much more closely related to chicken CT precursors than to mammalian counterparts. The topology of this phylogenetic tree is consistent with the similarity among CT peptides from these species (Sasayama 1999, Suzuki et al 1999b, and further suggests that the CT genes of teleost and chicken might be more similar than is estimated by phylogenetic analysis of CT regions (Clark et al 2002).…”

Section: Rainbow Trout Sct Cdna and Precursorsupporting

confidence: 76%

“…Intriguingly, their patterns of tissue expression were remarkably different: sCT-IV mRNA was detected in the testis, whereas sCT-V mRNA occurred in most tissues examined. Expression of CT mRNA had already been reported in the gills of pink salmon and rainbow trout (Martial et al 1994, Sasayama 1999), but our RT-PCR analysis revealed that the CT mRNA expressed in this tissue is only sCT-I. In addition, in situ hybridization histochemistry showed expression of sCT-IV gene in the Leydig cells of trout testis.…”

Section: Discussionsupporting

confidence: 56%

“…Down the phylogenetic lineages of vertebrates, non-mammalian calcitonin is produced by the ultimobranchial gland, and the sequences of CT peptides and mRNAs have been determined in a number of species, from fish to mammals (Sasayama 1999, Suzuki et al 1999b. Sequence analysis reveals that CT is a 32 amino acid polypeptide that is derived from a larger precursor molecule, and further that some species produce more than one form of CT (Suzuki et al 1999b).…”

Section: Introductionmentioning

confidence: 99%

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Identification and tissue distribution of mRNAs encoding salmon-type calcitonins-IV and -V in the rainbow trout

Hidaka

Suzuki

2004

Journal of Molecular Endocrinology

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Four types of calcitonin are produced in salmonid fish, although their functional diversity is almost unknown. To explore the significance of these isoforms, we have characterized salmon-type calcitonin (sCT) mRNAs in the rainbow trout (Oncorhynchus mykiss), and examined their tissue distribution. In addition to the previously isolated sCT-I cDNAs, two new forms of sCT cDNA were cloned from the ultimobranchial gland, and one of them (sCT-IV cDNA) was predicted to encode an N-terminal peptide of 80 amino acid residues, a putative cleavage site Lys-Arg, sCT-IV, a cleavage and amidation sequence Gly-Lys-Lys-Arg, and a C-terminal peptide of 18 amino acids. The sCT-IV precursor was 78% identical with the rainbow trout sCT-I precursors. The other cloned cDNA encoded a precursor for a novel CT, sCT-V. The sCT-V peptide was different from sCT-IV by only one amino acid residue: Val at position 8 in the latter was replaced by Met. The sCT-V precursor had 80 and 90% identity with the sCT-I and -IV precursors respectively. No cDNA clones were obtained for sCTs-II or -III.Tissue distribution of sCT-I, -IV and -V mRNAs was examined by RT-PCR and specific cleavage with restriction enzymes. An amplified fragment from sCT-I mRNA was detected not only in the ultimobranchial gland, but also in the gills, testis and ovary. RT-PCR analysis coupled to restriction digestion further revealed that sCT-IV mRNA was expressed in both the testis and the ultimobranchial gland. The expression sites of sCT-IV mRNA were localized to the Leydig cells of the testis and to the parenchymal cells of the ultimobranchial gland, by in situ hybridization histochemistry. Although the amino acid sequence of sCT-V peptide was nearly the same as that of sCT-IV, the sCT-V gene showed a much wider pattern of expression: the band amplified by RT-PCR was detected in all the tissues examined except the kidney, gills and blood cells. The sCT-V mRNA was shown to be localized in the parenchymal cells of the ultimobranchial gland, but not in other tissues at the cellular level, suggesting very low expression of sCT-V mRNA in those tissues. Our results show different patterns of tissue expression of three types of sCT genes in the rainbow trout, suggesting that sCTs-I, -IV and -V might differ in their local actions.

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Section: Rainbow Trout Sct Cdna and Precursorsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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Identification and tissue distribution of mRNAs encoding salmon-type calcitonins-IV and -V in the rainbow trout

Hidaka

Suzuki

2004

Journal of Molecular Endocrinology

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“…In teleosts, active sites of calcium deposition are considered to be the skeletal bone and scales (Sasayama, 1999), and it is reported that sCT stimulates the growth of these tissues in a cichlid fish (Wendelaar Bonga and Lammers, 1982). CT also suppresses osteoclastic activities in the scales of other fishes (Suzuki et al, 2000a).…”

Section: Discussionmentioning

confidence: 99%

“…regulation of the sperm mobility and capacitation (Gnessi et al, 1984;Fraser et al, 2001), and of the embryonic implantation and development (Ding et al, 1994;Wang et al, 1998). As for fish, accumulating evidence also indicates that CT may be synthesized in various tissues including the ultimobranchial gland, the major production site of fish CT (Martial et al, 1994;Sasayama 1999;Clark et al, 2002). Although its physiological significance is controversial, it is suggested that serum fish CT might protect scales from excessive resorption in the goldfish ( Carassius auratus ) and nibbler fish ( Girella punctata ) (Suzuki et al, 2000a), and be involved in the reproductive physiology of rainbow trout ( Oncorhynchus mykiss ) (Bjornsson et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Shift of Chloride Cell Distribution during Early Life Stages in Seawater-Adapted Killifish, Fundulus heteroclitus

et al. 2000

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Stimulatory effects of short-term calcitonin administration on plasma calcium, magnesium, phosphate, and glucose in juvenile Siberian sturgeon Acipenser baerii

Jafari

Abdollahpour

Falahatkar

2020

Fish Physiol Biochem

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Hormonal Control of Ca Homeostasis in Lower Vertebrates: Considering the Evolution

Cited by 31 publications

References 95 publications

Identification and tissue distribution of mRNAs encoding salmon-type calcitonins-IV and -V in the rainbow trout

Identification and tissue distribution of mRNAs encoding salmon-type calcitonins-IV and -V in the rainbow trout

Shift of Chloride Cell Distribution during Early Life Stages in Seawater-Adapted Killifish, Fundulus heteroclitus

Stimulatory effects of short-term calcitonin administration on plasma calcium, magnesium, phosphate, and glucose in juvenile Siberian sturgeon Acipenser baerii

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