Hormonal Contraceptive Use Among Adolescent Girls in Germany in Relation to Health Behavior and Biological Cardiovascular Risk Factors

Du, Yong; Rosner, Bettina; Knopf, Hildtraud; Schwarz, Sabine; Dören, Martina; Scheidt‐Nave, Christa

doi:10.1016/j.jadohealth.2011.01.004

Cited by 21 publications

(38 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of the present study indicate that HDL function is influenced by oral contraceptives in a similar manner, as there was no difference in HDL function between males and females without oral contraceptives. A large study of German adolescents has shown a correlation between oral contraceptives and an unfavorable CVD risk factor profile [27]. They found increased levels of both CRP and HDL in users of oral contraceptives, which is in line with a recent study of adult women [28].…”

Section: Discussionsupporting

confidence: 77%

Reduced HDL function in children and young adults with type 1 diabetes

Heier

Borja²,

Brunborg

et al. 2017

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundPatients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum levels of HDL cholesterol. The objective of this study was to evaluate HDL function in T1D patients shortly after disease onset compared with healthy control subjects.MethodsParticipants in the atherosclerosis and childhood diabetes study were examined at baseline and after 5 years. At baseline, the cohort included 293 T1D patients with a mean age of 13.7 years and mean HbA1c of 8.4%, along with 111 healthy control subjects. Their HDL function, quantified by HDL-apoA-I exchange (HAE), was assessed at both time points. HAE is a measure of HDL’s dynamic property, specifically its ability to release lipid-poor apolipoprotein A-I (apoA-I), an essential step in reverse cholesterol transport.ResultsThe HAE-apoA-I ratio, reflecting the HDL function per concentration unit apoA-I, was significantly lower in the diabetes group both at baseline, 0.33 (SD = 0.06) versus 0.36 (SD = 0.06) %HAE/mg/dL, p < 0.001 and at follow-up, 0.34 (SD = 0.06) versus 0.36 (SD = 0.06) %HAE/mg/dL, p = 0.003. HAE-apoA-I ratio was significantly and inversely correlated with HbA1c in the diabetes group. Over the 5 years of the study, the mean HAE-apoA-I ratio remained consistent in both groups. Individual changes were less than 15% for half of the study participants.ConclusionsThis study shows reduced HDL function, quantified as HAE-apoA-I ratio, in children and young adults with T1D compared with healthy control subjects. The differences in HDL function appeared shortly after disease onset and persisted over time.

show abstract

Section: Discussionsupporting

confidence: 77%

Reduced HDL function in children and young adults with type 1 diabetes

Heier

Borja²,

Brunborg

et al. 2017

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…We observed a higher prevalence of HC use among the most advantaged social classes and among women with smoking history, and we observed a lower prevalence of HC use among obese women, in agreement with previous literature. [15][16][17][18] Our rate of ever use of HT (9.8%) falls within the ranges of two other Spanish surveys conducted among women attending breast cancer screening programs (prevalence of 5.2% and 12.0%). 8,9 A cross-sectional telephone survey in 2002 observed that 22.3% of women aged 45 to 65 years had ever been prescribed HT, using a sample from the reference population of a primary healthcare center.…”

Section: Costas Et Alsupporting

confidence: 54%

Hormonal contraception and postmenopausal hormone therapy in Spain

et al. 2015

View full text Add to dashboard Cite

show abstract

“…It is possible that withdrawal from the use of OCs can lower DBP. Indeed when this was tested in 171 women on OCs for 6 months, both the DBP and SBP declined by 10.4 mmHg and 15.1 mmHg, respectively18 However, the association between HC use and CV risk factors among 2,285 young German girls aged 13–17 years gave relative contributions of HC use to be <1% for SBP and DBP 19. Other age-related factors may be involved in BP increase.…”

Section: Discussionmentioning

confidence: 99%

Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community

Asare¹,

Santa²,

Ngala³

et al. 2014

IJWH

View full text Add to dashboard Cite

BackgroundHormonal contraceptives (HCs) have been shown to alter lipid profile among various population groups with different patterns of dyslipidemia and cardiovascular (CV) risk. The study aimed at determining the lipid profile pattern and CV risk in a Ghanaian cohort.MethodsPurposive random sampling was done. Forty-seven and 19 cases were on oral contraceptives (OCs) and injectable contraceptives (ICs), respectively; five were on subdermal implant. Twenty-four non-users served as controls. Biodemographic and lipid profiles were determined. Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and very-low-density lipid lipoprotein cholesterol (VLDLC), were determined. Castelli index I and II were calculated.ResultsThe mean age difference between the HC and control groups was insignificant. However, diastolic blood pressure (BP) differences were significant (P=0.006). The body mass index (BMI) of the OC and IC groups were significantly different from the control group (P=0.003 and P=0.008, respectively). TC levels for the control and case groups were 3.35±0.62 mmol/L and 4.07±0.91 mmol/L, respectively (P=0.002). LDLC levels for the control and case groups were 1.74±0.57 mmol/L and 2.38±0.84 mmol/L, respectively (P=0.003). Castelli index I (TC/HDLC) and II (LDLC/HDLC) were significantly different between the control and OC groups (P=0.026 and P=0.014, respectively). Spearman’s rho correlation showed significant influence of HC use on TG (P=0.026), TC (P=0.000), LDLC (P=0.004), and VLDLC (P=0.026) over time.ConclusionHC use is associated with significant increases in BMI, diastolic BP, TC, LDLC, and Castelli index I and II. These changes carry a potential risk in the development of CV disease.

show abstract

Hormonal Contraceptive Use Among Adolescent Girls in Germany in Relation to Health Behavior and Biological Cardiovascular Risk Factors

Cited by 21 publications

References 34 publications

Reduced HDL function in children and young adults with type 1 diabetes

Reduced HDL function in children and young adults with type 1 diabetes

Hormonal contraception and postmenopausal hormone therapy in Spain

Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community

Contact Info

Product

Resources

About