Hormonal contraception for women exposed to HIV infection

Hofmeyr, G Justus; Singata, Mandisa; Sneden, Jennifer

doi:10.1002/14651858.cd009741

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…In the context of the above findings, it would be worthwhile clarifying whether the use of injected contraceptives associated with a moderate increased risk for HIV-1 infection in high-risk populations [43,44] may be due to altered PMN behaviour in the FRT.…”

Section: Nets In the Vaginal Mucosa Tackle Virusesmentioning

confidence: 99%

The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines

Hahn

Harmatz

Vokálová

et al. 2019

Clinical and Experimental Immunology

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Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrating this regulation are cyclical steroid sex hormones present during the menstrual cycle and pregnancy. This review describes the role of sex hormones in regulating directly or indirectly the functionality of neutrophils, the role of neutrophils during fertilization and pregnancy and in controlling viral, fungal and bacterial infection. This review also discusses the consequence of overt neutrophil activation in pregnancy pathologies.Our intention in this review is to highlight new observations made during discrete stages of the reproductive cycle, focusing particularly on the role of sex hormones and cytokines in modulating neutrophil activity and their potential dysregulation in pathology.

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Section: Nets In the Vaginal Mucosa Tackle Virusesmentioning

confidence: 99%