Hormonal Characteristics of Androgen Status in Males of Different Age Groups

Selyatitskaya, V. G.; Епанчинцева, Е. А.; Новикова, Е Г; Shilina, N I; Пинхасов, Б. Б.

doi:10.1134/s2079057020030169

Cited by 2 publications

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References 13 publications

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“…В свою очередь, ГЛЖ и ХСН, как и ФП, являются следствием ремоделирования миокарда на фоне длитель- ного течения неконтролируемой артериальной гипертензии [20,21,22]. АнД был выявлен примерно у трети обследованных пациентов, что хорошо соотносится с ранее полученными результатами обследования практически здоровых мужчин соответствующего возраста в г. Новосибирске [23], а ГЭ отмечена у 1/2 обследованных пациентов, что превышает результаты других исследований [24,25]. Можно предположить, что этот феномен обусловлен высокой частотой в выборке обследованных мужчин ожирения, о чем уже было сказано выше, при котором повышенное количество жировой ткани ассоциировано с большей конверсией тестостерона в эстрадиол ароматазой адипоцитов [26].…”

Section: Discussionunclassified

“…Следует отметить, что при развитии возрастного АнД снижение уровня ДГЭА-С в сыворотке крови выражено даже сильнее, чем уровней Тобщ. и Тсв., однако, в отличие от полученных нами в настоящем исследовании результатов, возрастное снижение уровней андрогенов у практически здоровых мужчин, частично компенсируется повышением уровня ЛГ [23]. У мужчин с ГБ из Г2 повышения уровня ЛГ не было обнаружено, что позволяет предполагать нарушение гипофизарной регуляции функциональной активности периферических желёз внутренней секреции (надпочечников и гонад).…”

Section: Discussionunclassified

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Hormonal characteristics of androgen status and their relationship with the anthropometric and metabolic parameter in men depending on the severity of hypertension

Yankovskaya

Кузьминова

Пинхасов

et al. 2022

Acta biomedica scientifica

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Background. According to the literature data, long-term and poorly controlled hypertension (HTN) leads to target organs damage, and in some cases, to the development of associated diseases, the severity of which in men may be partly due to the characteristics of the androgenic status.The aim: to reveal the features of hormonal indicators of androgen status and their relationship with the anthropometric and metabolic characteristics of the therapeutic clinic male patients, depending on the severity of HTN.Materials and methods. 296 men aged 59,0 [54,0; 65,0] years with confirmed HTN were examined. All study participants in the morning on an empty stomach underwent anthropometry, determination of metabolic and androgenic status, and assessment of comorbid burden. Depending on the severity of hypertension, all patients were divided into two groups (G): G1 (n = 134) – patients with hypertension without a history of coronary artery disease or stroke; G2 (n = 162) – patients with hypertension with a history of ischemic heart disease (IHD) and/or stroke.Results. In male patients of G2 with severe HTN, a decrease in the levels of free testosterone (FT) and, to a greater extent, dehydroepiandrosterone sulfate (DHEA-S), as well as total cholesterol, high and low density lipoproteins, was revealed. The correlation analysis performed revealed statistically significant negative correlations between the levels of total testosterone (TT) and FT with body mass index, the value of the ratio of waist circumference to hips, only the level of FT – with the presence of IHD, chronic heart failure (CHF), disorders of carbohydrate metabolism and abdominal type of fat distribution, and the level of DHEA-S – with the presence of IHD and CHF.Conclusion. A decrease in FT and DHEA-S is associated with early progression of atherosclerosis and the risk of developing HTN-associated cardiovascular events, which can aggravate the course of HTN.

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Section: Discussionunclassified

Hormonal characteristics of androgen status and their relationship with the anthropometric and metabolic parameter in men depending on the severity of hypertension

Yankovskaya

Кузьминова

Пинхасов

et al. 2022

Acta biomedica scientifica

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“…Данная закономерность может быть обусловлена возрастными особенностями выборки пациентов, так как известно, что у мужчин с увеличением возраста происходит накопление жировой МТ и доли лиц с ожирением [12]. АнД в зависимости от выбранного критерия был отмечен у 30-40 % обследованных пациентов, а ГЭ -примерно у 26 %, что хорошо соотносится с результатами предыдущих исследований и данными других авторов [13][14][15].…”

Section: Discussionunclassified

Association of rs9939609 polymorphism in the FTO gene with features of androgen status in men

Yankovskaya

Mosalev

Ivanov

et al. 2022

Sibirskij nauchnyj medicinskij zhurnal

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The purpose of the study was to investigate the association of carriage of rs9939609 polymorphism in the FTO gene with features of androgen status in men.Material and methods. The observational one-stage examination of 139 male patients aged 22 to 69 years, admitted to a therapeutic hospital in a planned manner has been carried out in the Clinic of the Federal Research Center for Fundamental and Translational Medicine in the period 2020–2021. All fasting men in the morning (8:00–8:30) were carried out of an anthropometric examination to determine physical development, sampling of venous blood from the cubital vein to assess the hormonal parameters of androgen status, and taking a sample of the buccal epithelium for molecular genetic research. Based on the carriage of the rs9939609 (T>A) polymorphism of the FTO gene, the following groups (G) of patients were distinguished: G1 – wild-type homozygotes (WT/WT), G2 – heterozygotes (WT/A), G3 – homozygotes for the mutant allele (A/A).Results and discussion. The statistically significant differences were found in the levels of total testosterone between G1 and G3 (11.6 vs 14.5 nmol/L, p = 0.010), as well as free testosterone in G1 compared to G2 (0.233 vs 0.287 nmol/L, p = 0.012) and G3 (0.233 vs 0.321 nmol/L, p = 0.002) when analyzing the clinical-anthropometric and hormonal features of the androgen status of the examined male patients in the selected groups. Assessment of the association revealed statistically significant positive correlations between the carriage of the mutant allele and the levels of total (r = 0.247; p = 0.013) and free (r = 0.296; p = 0.003) testosterone, and negative - with the frequency of androgen deficiency according to the free testosterone criteria (r = –0.240; p = 0.016).Conclusions. It has been shown that the carriage of the A/A genotype of rs9939609 polymorphism of the FTO gene is associated with an increase in the levels of total and free testosterone, that indicates a protective effect against the development of androgen deficiency in men. The obtained results suggest that this effect is due to the epigenetic effect of the FTO gene protein product on the expression of other genes involved in the synthesis of androgens in the gonads, but also in the adrenal cortex since no association of the carriage of the rs9939609 polymorphism of the FTO gene with the DHEA-C level was found.

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Hormonal Characteristics of Androgen Status in Males of Different Age Groups

Cited by 2 publications

References 13 publications

Hormonal characteristics of androgen status and their relationship with the anthropometric and metabolic parameter in men depending on the severity of hypertension

Hormonal characteristics of androgen status and their relationship with the anthropometric and metabolic parameter in men depending on the severity of hypertension

Association of rs9939609 polymorphism in the FTO gene with features of androgen status in men

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