Hormonal Changes in 3-Month-Old Cryptorchid Boys

Suomi, Anne-Maarit; Main, Katharina M.; Kaleva, Marko; Schmidt, Ida Maria; Chellakooty, Marla; Virtanen, Helena E.; Boisen, Kirsten A; Damgaard, Ida; Kai, Claudia Mau; Skakkebæk, Niels E.; Toppari, Jorma

doi:10.1210/jc.2004-2318

Cited by 125 publications

(118 citation statements)

References 31 publications

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“…Three month old male infants with cryptorchidism were shown to have significantly elevated levels of FSH and LH as well as reduced inhibin B concentrations compared with controls (38). Similar changes in hormone levels were also seen in boys with hypospadias (39).…”

Section: Evidence From Human Retrospective Studiesmentioning

confidence: 66%

Is male infertility a forerunner to cancer?

et al. 2010

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Purpose: The frequency of testicular cancer and male infertility has been increasing in the past several decades. This article examines the relationship between male infertility and testicular cancer, concentrating particularly on causal links. Results: Both of these disorders are associated with testicular dysgenesis syndrome and have also been traced to mutations in genes involving DNA repair and tumor suppression, as well as environmental exposure. Conclusion:The identification and examination of these common points of origin supports the integration of testicular cancer screenings into the routine evaluation of infertile men.

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Section: Evidence From Human Retrospective Studiesmentioning

confidence: 66%

Is male infertility a forerunner to cancer?

et al. 2010

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“…Полученные нами данные сопо-ставимы с результатами A. Suomi и соавт. [11], ко-торые при обследовании мальчиков с крипторхиз-мом в возрасте 3 мес выявили увеличение содержа-ния гонадотропинов и снижение уровня ингибина B, увеличение соотношений ЛГ/тестостерон и ФСГ/ингибин B. Показатели тестостерона и глобу- …”

Section: результаты и обсуждениеunclassified

“…Изучение мини-пубертата у мальчиков с крипторхизмом представляется перспективным для определения потенциала репродуктивной системы. При анализе данных литературы [10,11] мы обнару-жили единичные исследования, характеризующие мини-пубертат у пациентов с крипторхизмом, одна-ко они не учитывают зависимость клинико-гормо-нальных показателей от уровня задержки яичка. Цель настоящего исследования -оценка функ-ционального состояния гонад у мальчиков с различ-ными формами крипторхизма на основании пост-натального гормонального обследования.…”

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The state of the testis in the boys presenting with cryptorchism during the mini-pubertal period

Райгородская¹,

Bolotova²,

Морозов³

et al. 2014

Probl Endokrinol (Mosk)

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The period of transitory postnatal activation of the hypotalamo-pitutary-gonadal axis (mini-puberty) plays an important role in the testicular maturation and the development of the reproductive system. The objective of the present study was to evaluate the functional condition of the testicles in the boys at the age of 2-3 months born with cryptorchism. A total of 32 boys presenting with inguinal retention of the testes (group 1), 10 patients with unilateral abdominal criptorchism (group 2), and 40 healthy boys ages 2-3 month (control group) were available for the clinical examination and hormonal analysis. The methods employed in the study included orchidometry and genitometry, meagurement of serum gonadotropin, testosterone, and inhibin B levels by immunoenzyme assays. The results investigations made it possible to diagnose gonadal pathology in 80% of the examinad children presenting with unilateral abdominal cryptorchism and subclinical disorders of the testicular function in 40% of the patients with inguinal retention of a testicle.

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“…Androgens play a crucial role in the development of male external genital organs and testicular descent. Hormonal dysregulation can be one out of many etiological factors of cryptorchidism (Suomi 2006). Testicular descent is at least partly dependent on fetal testicular testosterone, which in turn is initiated and maintained by human chorionic gonadotropin produced by the placenta (Biggs 2002).…”

Section: Pathogenesis Of Cryptorchidismmentioning

confidence: 99%

“…There are various forms of cryptorchidism (congenital with or without spontaneous descent, mild versus severe, acquired). These forms may reflect distinct hormonal patterns which differ in each situation (Suomi 2006). Apart from anatomical configuration and hormonal stimulation, genetic control of testis descent is very important.…”

Section: Hormonal Regulation Of Testicular Descentmentioning

confidence: 99%