Hormonal Changes and Sexual Function in Aging Men*

Davidson, Julian M.; Chen, Jeanette J.; Crapo, Larry; Gray, Gary D.; Greenleaf, Walter J.; Catania, Joseph A.

doi:10.1210/jcem-57-1-71

Cited by 359 publications

(185 citation statements)

References 20 publications

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“…24,25 A similar effect of aging has been reported on the development of BPH, with the age-dependent decrease in prostatic dihydrotestosterone with stable estradiol concentration leading to a relatively estrogen-dominant environment inducing stromal proliferation. 26 Smoking was another variable reported to be a risk factor for the development of ED and cardiovascular disease.…”

Section: Correlation Between Luts and Edmentioning

confidence: 56%

Correlation between LUTS (AUA-SS) and erectile dysfunction (SHIM) in an age-matched racially diverse male population: data from the Prostate Cancer Awareness Week (PCAW)

et al. 2005

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The relationship between lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia and sexual health in men participating in a national multicenter screening program was studied. A total of 12 679 men were screened for prostate cancer in the year 2003. Of these, 6641 men had completed both the American Urological Association Symptom Score (AUA-SS) and the Sexual Health Inventory for Men (SHIM) questionnaires. We assessed the apparent effect of comorbidities (ischemic heart disease, hypertension, hypercholesteremia and diabetes), smoking habits and testosterone level on the overall sexual health. Age and race were also assessed as factors affecting the SHIM score. We used a general linear multivariable regression analysis to express the effect of these variables on the sexual health in these men adjusting for the apparent effect of LUTS. The mean and median age of the population was 58.479.8 and 58 y, respectively. The median AUA-SS was 4/25 (mean ¼ 5.775.3) and SHIM score was 19/25 (mean ¼ 16.375.9). Of the men, 4948 (75%) were Caucasian and 1154 (17%) were from African-American racial origin. A high AUA-SS appears to have a negative effect on the overall sexual health (Po0.05) after adjusting for all other confounding factors. As expected, age showed a significant inverse correlation with SHIM score (Po0.05). Caucasian men on average appear to have a significantly higher SHIM score by 6.5 points when compared to African-American men after adjusting for age, comorbidities, smoking habits, and AUA-SS (Po0.05). However, with increasing age, the difference in SHIM score diminishes between the two groups. Further, smoking and comorbidities were strong predictors of poor sexual health performance. Interestingly, hypogonadism (testosterone o300 ng/dl) was not a significant risk factor (P ¼ 0.104) when adjusting for all other variables. Nonetheless, in a univariate analysis, testosterone levels significantly correlated with reported SHIM scores (Po0.05). The overall sexual health in aging men is substantially affected not only by age, but by the severity of their urinary symptoms after adjusting for the most common known risk factors, suggesting perhaps a common underlying pathophysiology. Moreover, race appears to constitute another neglected potential risk factor, which should be investigated further in future studies.

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Section: Correlation Between Luts and Edmentioning

confidence: 56%

Correlation between LUTS (AUA-SS) and erectile dysfunction (SHIM) in an age-matched racially diverse male population: data from the Prostate Cancer Awareness Week (PCAW)

et al. 2005

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“…6,7 Declining T is often blamed for the sexual decline in elderly males, but statistically controlling on T does not fully explain male decline in sexuality with age. 8,9 Unless very low, T is not well correlated with sexual behavior, and T replacement therapy is usually ineffective for erectile dysfunction (ED) in elderly men. 10,11 Health and fitness Poor health is sufficient to eliminate sexual interest and ability in aged men, and ED may foretell vascular disease.…”

Section: Testosterone (T)mentioning

confidence: 99%

Causes of sexual decline in aging married men: Germany and America

et al. 2002

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Married men in Germany (n ¼ 48) and America (n ¼ 50) between 50 and 80 years old, none in poor health, provided comparable information on sexual behavior and attitudes, and gave saliva samples from which testosterone was assayed. Sexuality declines with age, as expected. Neither testosterone nor psychological depression explain levels of sexuality. In both nations, wife's desire for intercourse, subject's ability to maintain an erection, and subject's imagination about other women, explain certain aspects of sexuality. Subject's health and marital satisfaction are related to sexuality among Americans but not among Germans. Behavioral models for the two nations are compared.

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“…57,58 This may suggest such changes in sexual behavior are androgen dependent, but this does not prove the cause. Although erectile dysfunction in older men is often of nonhormonal etiology, T deficiency accounts for 6%-45% of all cases.…”

Section: Sexual Functionmentioning

confidence: 99%

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Lang

Samaras

2012

Rejuvenation Research

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Testosterone replacement therapy is often equated with the macho male physique and virility and is viewed by some as an antiaging tonic. The growth in testosterone's reputation and its increased use by men of all ages has seemed to outpace the scientific evidences. This review will aim to examine the uncertainty regarding the nature and the clinical importance of the age-related reduction in the testosterone levels. Considerations will be given both to clinical symptoms, biochemical and clinical diagnostic criteria, and to the risk-to-benefit ratio of reversing late-onset hypogonadism in aging and older men.

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Hormonal Changes and Sexual Function in Aging Men*

Cited by 359 publications

References 20 publications

Correlation between LUTS (AUA-SS) and erectile dysfunction (SHIM) in an age-matched racially diverse male population: data from the Prostate Cancer Awareness Week (PCAW)

Correlation between LUTS (AUA-SS) and erectile dysfunction (SHIM) in an age-matched racially diverse male population: data from the Prostate Cancer Awareness Week (PCAW)

Causes of sexual decline in aging married men: Germany and America

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

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