Hormonal and Nutritional Regulation of IGF-I and Its Binding Proteins

Underwood, Louis E.; Thissen, Jean Paul; Lemozy, S; Ketelslegers, J. M.; Clemmons, David R.

doi:10.1159/000184187

Cited by 213 publications

(116 citation statements)

References 39 publications

(46 reference statements)

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“…It is well known that nutritional status effects IGF-I levels more than IGFBP-3 levels (Baxter and Martin, 1986;Thissen et al, 1994). Low IGF-I levels were observed in chronic disease and malnutrition whereas IGFBP-3 remains relatively unchanged (Baxter and Martin, 1986;Thissen et al, 1994;Underwood et al, 1994). IGFBP-3 correlated with anthropometric measurements in boys but not in girls, suggesting sexual dimorphism.…”

Section: Discussionmentioning

confidence: 93%

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

et al. 2006

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Objectives: The effect of economic status (ES) on growth, insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in healthy children is not well characterized. We aimed to study the interrelationship between height, weight, IGF-I, IGFBP-3, mid-parental height (MPH) and ES. Design/subjects: Eight hundred and fourteen healthy children (428 boys, 386 girls; age 3-18 years) were classified according to income of the families as low, middle and high. Standard deviation scores (SDSs) of height, weight, MPH, IGF-I and IGFBP-3 were compared between the groups. The combined effect of these parameters and ES on height SDS was investigated with complex statistical models. Results: There was a significant trend for height and weight SDSs to increase with higher income levels in boys, but not in girls. Body mass index (BMI) SDSs were similar in three groups. There was a general trend for MPH SDS to increase with income levels in both sexes. In boys, IGF-I SDS was significantly higher in high ES group than low ES. In girls, IGFBP-3 SDSs were significantly higher in high ES group than in middle ES group. For both genders, height SDS was highly correlated with weight SDS and moderately correlated with BMI SDS, MPH SDS and IGF-1 SDS. All correlations were significant and positive. Complex models showed that MPH (19%), IGF-I (13%) and ES (3%) in boys, and MPH (16%) and IGF-I (7%) in girls have significant contribution to height SDSs. Conclusions: ES per se, independent of overt malnutrition, affects height, weight, IGF-I and IGFBP-3 with some gender differences in healthy children. Influence of income on height and weight show sexual dimorphism, a slight but significant effect is observed only in boys. MPH is the most prominent variable effecting height in healthy children. Higher height and MPH SDSs observed in higher income groups suggest that secular trend in growth still exists, at least in boys, in a country of favorable economic development.

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Section: Discussionmentioning

confidence: 93%

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

et al. 2006

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“…Linear growth is directly controlled by GH, in part via IGF-I (26,27), with other factors such as nutrition and the hormonal environment playing modulatory roles (10,28). To the best of our knowledge, the effect of malnutrition on the IGF-I system during puberty has not been reported previously.…”

Section: Discussionmentioning

confidence: 95%

“…Undernutrition, or poor nutrition, inhibits growth in the laboratory rat (5,10,11) and is one of the major causes of short stature in humans (31,32). In agreement, we now show that undernutrition of peripubertal rats significantly reduced body weight, which at this age is directly proportional to linear growth (33).…”

Section: Discussionmentioning

confidence: 99%

Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis

Goya

García‐Segura²,

Ramos³

et al. 2002

European Journal of Endocrinology

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Objective: In malnutrition both the GH -IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. Design and methods: Peripubertal (30 days of age) female rats were either sham operated or ovariectomized. Five days later half of each group was submitted to a protein-caloric restriction diet. All rats were killed at 60 days of age. Results: Growth was decreased in all rats submitted to calorie restriction and this was consistent with a decrease in circulating IGF-I concentrations and liver IGF-I mRNA expression. While in normally fed rats ovariectomy had no significant effect on serum IGF-I concentrations, ovariectomized and underfed rats had significantly higher levels than intact underfed rats. In undernourished rats, serum IGF-binding proteins (IGFBP)-1, -2 and -3 concentrations were significantly reduced and this was not modified by ovariectomy. In contrast, liver mRNA concentrations of IGFBP-1 and -2 were increased and IGFBP-3 unchanged in intact undernourished animals, suggesting that undernutrition could be affecting the proteolysis of these binding proteins, and this response was significantly modulated by ovariectomy. Conclusion: These results indicate that the presence of circulating ovarian hormones significantly affects the response of the IGF system to undernutrition.

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“…Nutrition is a major regulator of IGF-1 (Underwood, 1996). Fasting results in a decrease while overnutrition results in an increase in IGF-1 levels although the exact nature of the dose -response relationship between food intake and levels of IGFs in circulation remains to be determined.…”

Section: Glycemic Index In Chronic Diseasementioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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Hormonal and Nutritional Regulation of IGF-I and Its Binding Proteins

Cited by 213 publications

References 39 publications

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis

Glycemic index in chronic disease: a review

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