Hormonal and nutritional regulation of insect fat body development and function

Liu, Ying; Liu, Hanhan; Liu, Shumin; Wang, Sheng; Jiang, Rong‐Jing; Li, Sheng

doi:10.1002/arch.20291

Cited by 7 publications

(9 citation statements)

References 47 publications

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“…Glucose, apart from its use in energy metabolism and heat generation during the cold, is important in the chitinous exoskeleton in insects while fatty acids are an important energy reserve for skeletal muscular activities such as hopping and flying, as well as secretion of pheromones and eicosanoids [ 7 ]. However, carbohydrate in insects is converted to trehalose (a disaccharide with O-α-D-Glucopyranosyl-(1 → 1)-α-D-glucopyranoside structure) and delivered to the fat body for storage in the form of glycogen [ 8 ]. Glycogen can be broken down to trehalose, which is secreted into the haemolymph for utilization [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Lipids on the other hand are digested to diacylglycerol. During the feeding period, most of the diacylglycerol is hydrolyzed to fatty acid and stored as triacylglycerol which can be converted back during molting, flight and oogenesis, and even stress conditions such as starvation, hypoxia and long-distance flight [ 8 , 10 ]. Amino acids from ingested proteins are also absorbed from the mid gut into the haemolymph from where they are transported to the fat body for storage.…”

Section: Introductionmentioning

confidence: 99%

“…It is responsible for storage of lipid, glycogen and protein. The fat body also senses, coordinates, and integrates multiple hormonal and nutritional signals involved in insect development and metamorphosis [ 8 ]. Apart from carrying out the crucial function of sensing energy and nutrient availability, and coordinating the appropriate metabolic and survival responses, it is also the site of coordination of responses to pathogen with metabolic status [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Fat body, fat pad and adipose tissues in invertebrates and vertebrates: the nexus

2014

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The fat body in invertebrates was shown to participate in energy storage and homeostasis, apart from its other roles in immune mediation and protein synthesis to mention a few. Thus, sharing similar characteristics with the liver and adipose tissues in vertebrates. However, vertebrate adipose tissue or fat has been incriminated in the pathophysiology of metabolic disorders due to its role in production of pro-inflammatory cytokines. This has not been reported in the insect fat body. The link between the fat body and adipose tissue was examined in this review with the aim of determining the principal factors responsible for resistance to inflammation in the insect fat body. This could be the missing link in the prevention of metabolic disorders in vertebrates, occasioned by obesity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fat body, fat pad and adipose tissues in invertebrates and vertebrates: the nexus

2014

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“…Furthermore, the fat body is involved in various humoral functions, including nutrition, reproduction, and longevity ( Ottaviani et al 2011 ). The transport of FAs from the fat body to other tissues is an aspect of lipid metabolism that is essential for insect development andmetamorphosis, and this transport is determined by developmental stage, nutritional state, sex, and migratory flight ( Arrese et al 2006 ; Liu et al 2009 ). Taken together, these observations suggest that AccFABP may be associated with the regulation of tissue-specific gene expression and lipid metabolism during honeybee development.…”

Section: Discussionmentioning

confidence: 99%

Identification and Expression Analysis of a Putative Fatty Acidbinding Protein Gene in the Asian Honeybee,Apis cerana cerana

Kang

Liu

et al. 2013

Journal of Insect Science

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Fatty acid-binding proteins (FABPs) play pivotal roles in cellular signaling, gene transcription, and lipid metabolism in vertebrates and invertebrates. In this study, a putative FABP gene, referred to as AccFABP, was isolated from the Asian honeybee, Apis cerana cerana Fabricius (Hymenoptera: Apidae). The full-length cDNA consisted of 725 bp, and encoded a protein of 204 amino acids. Homology and phylogenetic analysis indicated that AccFABP was a member of the FABP multifamily. The genomic structure of this gene, which was common among FABP multifamily members, spanned 1,900 bp, and included four exons and three introns. Gene expression analysis revealed that AccFABP was highly expressed in the dark-pigmented phase of pupal development, with peak expression observed in the fat bodies of the dark-pigmented phase pupae. The AccFABP transcripts in the fat body were upregulated by exposure to dietary fatty acids such as conjugated linoleic acid, docosahexaenoic acid, and arachidonic acid. Transcription factor binding sites for Caudal-Related Homeobox and functional CCAAT/enhancer binding site, which were respectively associated with tissue expression and lipid metabolism, were detected in the 5′ promoter sequence. The evidence provided in the present study suggests that AccFABP may regulate insect growth and development, and lipid metabolism.

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“…The fat body is essential for coordinating metabolism through different hormonal and nutritional signals regulating insect development, metamorphosis, and reproduction (Canavoso et al, 2001;Colombani et al, 2005;King-Jones & Thummel, 2005;Nelliot et al, 2006;Aguila et al, 2007). Indeed, a strong Drosophila hexamerin promoter (previously characterized by us; Beneš et al, 1996) was successfully used for transgenic ablation of the larval fat body and proved its indispensability for pupal metamorphosis and adult development (Liu et al, 2009). Using mathematical modelling, Phuc et al (2007) showed that a late-acting lethality was more effective in a population limited by density-dependent effects (e.g.…”

Section: Discussionmentioning

confidence: 99%

Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes

Totten

Vuong

Літвінова

et al. 2012

Insect Molecular Biology

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As the fat body is a critical tissue for mosquito development, metamorphosis, immune and reproductive system function, characterization of regulatory modules targeting gene expression to the female mosquito fat body at distinct life stages is much needed for multiple, varied strategies for controlling vector-borne diseases such as dengue and malaria. The hexameric storage protein, Hexamerin-1.2, of the mosquito, Aedes atropalpus, is female-specific and uniquely expressed in the fat body of fourth-instar larvae and young adults. We have identified in the Hex-1.2 gene, a short regulatory module that directs female-, tissue-, and stage-specific lacZ reporter gene expression using a heterologous promoter in transgenic lines of the dengue vector, Aedes aegypti. Male transgenic larvae and pupae of one line expressed no E. coli β-galactosidase or transgene product; in two other lines reporter gene activity was highly female-biased. All transgenic lines expressed the reporter only in the fat body. However, lacZ mRNA levels were no different in males and females at all stages examined, suggesting that the gene regulatory module drives female-specific expression by post-transcriptional regulation in the heterologous mosquito. This regulatory element from the Hex-1.2 gene thus provides a new molecular tool for transgenic mosquito control as well as functional genetic analysis in aedine mosquitoes.

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Hormonal and nutritional regulation of insect fat body development and function

Cited by 7 publications

References 47 publications

Fat body, fat pad and adipose tissues in invertebrates and vertebrates: the nexus

Fat body, fat pad and adipose tissues in invertebrates and vertebrates: the nexus

Identification and Expression Analysis of a Putative Fatty Acidbinding Protein Gene in the Asian Honeybee,Apis cerana cerana

Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes

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