Hormonal and neurochemical mechanisms of aggression and a new classification of aggressive behavior

Chichinadze, Konstantin; Chichinadze, Nodar; Lazarashvili, Ann

doi:10.1016/j.avb.2011.03.002

Cited by 27 publications

(18 citation statements)

References 166 publications

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“…For example, it has been reported that plasma testosterone levels correlate with testes size (Denk and Kempenaers 2005;Garamszegi et al 2005), ornament size or color (Buchanan et al 2001;Redpath et al 2006), territorial and aggressive behavior, including mate guarding (Soma 2006), singing behavior (De Ridder et al 2000;Foerster et al 2002), courtship behavior (Fusani et al 2007), and mating success (Raouf et al 1997;Redpath et al 2006;Kempenaers et al 2008) in birds. Similar observations have also been made in mammals and humans (Beehner et al 2006;Mazur 2006;Wingfield et al 2006;Scotti et al 2008;Chichinadze et al 2009Chichinadze et al , 2010Chichinadze et al , 2011.…”

Section: Introductionsupporting

confidence: 76%

Testosterone dynamics during encounter: role of emotional factors

et al. 2012

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This study attempts to develop a new theory to explain the varying dynamics of testosterone levels in dominant (winners) and subordinate (losers) males, both pre- and post-encounter. The crux of our new theory consists of the following four theses: (1) the strengthening of testosterone synthesis is a result of not only the existence of challenges, but also of a positive mood before an encounter that is associated with the anticipation of a victory; (2) in situations where the anticipation of victory is present but the positive mood is absent, no rise in testosterone levels will occur; (3) testosterone acts as a "pleasure" hormone and usually releases in situations where the individual achieves or anticipates possible satisfaction; (4) an increased release of testosterone to the blood not only decreases anxiety but also elevates the mood, which increases animal's/human's assertiveness and consequently aggressiveness.

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Section: Introductionsupporting

confidence: 76%

Testosterone dynamics during encounter: role of emotional factors

et al. 2012

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“…Arguably, “violence and aggression are the most serious problems facing humanity” [Chichinadze et al, ]. One approach in the study of aggression and its etiology is at a biochemical level.…”

Section: Introductionmentioning

confidence: 99%

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry

Hagenbeek

Kluft

Hankemeier

et al. 2016

American J of Med Genetics Pt B

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Human aggression encompasses a wide range of behaviors and is related to many psychiatric disorders. We introduce the different classification systems of aggression and related disorders as a basis for discussing biochemical biomarkers and then present an overview of studies in humans (published between 1990 and 2015) that reported statistically significant associations of biochemical biomarkers with aggression, DSM-IV disorders involving aggression, and their subtypes. The markers are of different types, including inflammation markers, neurotransmitters, lipoproteins, and hormones from various classes. Most studies focused on only a limited portfolio of biomarkers, frequently a specific class only. When integrating the data, it is clear that compounds from several biological pathways have been found to be associated with aggressive behavior, indicating complexity and the need for a broad approach. In the second part of the paper, using examples from the aggression literature and psychiatric metabolomics studies, we argue that a better understanding of aggression would benefit from a more holistic approach such as provided by metabolomics. Key words: aggression; biomarkers; psychiatry; metabolomics INTRODUCTIONArguably, "violence and aggression are the most serious problems facing humanity" [Chichinadze et al., 2011]. One approach in the study of aggression and its etiology is at a biochemical level.Biochemical markers are intermediate to the outward phenotype and the underlying biology of aggression. They can aid in elucidating the causes and (patho) physiology of aggressive behavior [James et al., 2006;Scoriels et al., 2015]. One of the promises of 719Neuropsychiatric Genetics biochemical studies of central nervous system diseases is the development of biochemically based biomarkers [KaddurahDaouk and Krishnan, 2009]. Biomarkers can be applied in diagnosis, in assessment of disease stages, as indicators of disease prognosis, and for prediction or monitoring of interventions and treatment responses. Some biomarkers are "surrogate endpoints" which substitute clinical endpoints that reflect "how a patient feels, functions, or survives" [Atkinson et al., 2001]. There are several comprehensive overviews of biochemical compounds as potential biomarkers for aggression [e.g., Siever, 2008;Yanowitch and Coccaro, 2011], including reviews of neurotransmitters [e.g., de Almeida et al., 2005;Seo et al., 2008;Siever, 2008;Wallner and Machatschke, 2009;Chichinadze et al., 2011;Yanowitch and Coccaro, 2011;Haller, 2013;Umukoro et al., 2013;Morrison and Melloni, 2014;Narvaes and Almeida, 2014;Willner, 2015], hormonal networks [Simpson and Hons, 2001;Wingfield et al., 2006;Siever, 2008;Soma et al., 2008;Chichinadze et al., 2011;Eisenegger et al., 2011; Haller, 2014a,c;Soma et al., 2015], and cytokines [e.g., Zalcman and Siegel, 2006]. With a few exceptions [e.g., Siever, 2008], these reviews focus on a single biochemical class, studying biomarkers belonging to various different biochemical pathways in isolation. This makes it...

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“…Recently, much emphasis has been placed on the need to explore the different mechanisms underlying diverse types of aggression from both a developmental perspective (Tremblay & Côté, ) and in relation to parenting styles (Casas et al, ; Kuppens, Grietens, Onghena, & Michiels, ), as well as in connection with hormones and neurochemicals (Chichinadze, Chichinadze, & Lazarashvili, ). Our study takes into consideration two types of aggression that involve two clearly distinguishable strategies for coping with conflict, and for which clearly differentiated distal causes have been suggested.…”

Section: Introductionmentioning

confidence: 99%

“…From a hormonal perspective, androgens (mainly testosterone) are the hormones that have most consistently been linked to aggressive behavior (Chichinadze et al, ; Moya, Serrano, & Ramírez, ). A positive association has been established between the levels of diverse androgens (above all testosterone) and aggressive behavior in a wide range of species, including humans (Brain, ; Trainor, Sisk, & Nelson, ).…”

Section: Introductionmentioning

confidence: 99%

Parenting styles and hormone levels as predictors of physical and indirect aggression in boys and girls

Pascual-Sagastizábal

Azurmendi

Braza

et al. 2014

Aggressive Behavior

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This study examines the relationship between parenting style, androgen levels, and measures of physical and indirect aggression. Peer ratings of aggression were obtained from 159 eight-yearold children (89 boys and 70 girls). Parenting styles (authoritative, authoritarian or permissive)were assessed using the Parenting Styles and Dimensions Questionnaire (PSDQ).Saliva samples were obtained from children and assayed for testosterone and androstenedione concentrations. A regression analysis revealed that high testosterone levels were associated with a higher level of physical aggression in boys with authoritarian mothers. Testosterone was also found to moderate the relationship between father's authoritarian parenting and physical aggression in girls, with both moderate and high levels being significant. In relation to indirect aggression, moderate and high levels of testosterone were associated with higher levels of this type of aggression in girls with permissive mothers. Our results highlight the importance of taking into account the interaction of biological and psychosocial variables when investigating aggressive behavior.

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Hormonal and neurochemical mechanisms of aggression and a new classification of aggressive behavior

Cited by 27 publications

References 166 publications

Testosterone dynamics during encounter: role of emotional factors

Testosterone dynamics during encounter: role of emotional factors

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry

Parenting styles and hormone levels as predictors of physical and indirect aggression in boys and girls

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