Hormesis

Jargin, Sergei V.

doi:10.1177/0960327114564796

Hum Exp Toxicol

2015

DOI: 10.1177/0960327114564796

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Hormesis

Sergei V. Jargin

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Cited by 6 publications

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“…Under such circumstances, which are common especially in gerontology, the hormesis concept can be precarious if used in the clinical decision-making. All clinically significant effects, hormetic or not, should be tested according to the principles of evidence-based medicine ( 25 ).…”

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Radiation Safety and Hormesis

Jargin

2020

Front. Public Health

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Radiation Safety and Hormesis

Jargin

2020

Front. Public Health

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“…Furthermore, the authors reveal that the biological responses induced by these homeopathic remedies show the traits that would normally characterize a hormetic dose–response mechanism. 6 – 11 Taking into account that both homeopathy and hormesis, as well as their mutual relationships, are attractors of criticism and controversy, 12 – 19 this result, in Calabrese’s opinion, is extremely significant. Using Calabrese’s words, it shows once again what happens when some scientists actually try to understand the physical system and what happens within it, while others are simply dismissive.…”

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Hormesis and Homeopathy: Toward a New Self-Consciousness

Dei

2017

Dose-Response

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Contrary to common belief, most new discoveries and theories are not merely additions to the existing stockpile of scientific knowledge; in order to assimilate them, the scientist usually has to rearrange his intellectual mind, discarding elements of his own previous theories. In this sense, he plays the role of a divergent thinker since the scientific community is often not ready to accept a new position for many reasons, among which not only lack of flexibility and open-mindedness but also political and economic interests. The gist of this thought 1 by Thomas Kuhn can be found in an important editorial by Edward Calabrese which recently appeared in Homeopathy. 2 The editorial concerns a manuscript published by Bellare and coworkers in the same issue of the journal, 3 in which the authors show that nanoparticles of different metals, that in previous articles had been unequivocally found at concentrations of a certain pg/mL in 30 CH and 200 CH homeopathic remedies, 4,5 induced a biological response. Furthermore, the authors reveal that the biological responses induced by these homeopathic remedies show the traits that would normally characterize a hormetic dose-response mechanism. 6-11 Taking into account that both homeopathy and hormesis, as well as their mutual relationships, are attractors of criticism and controversy, 12-19 this result, in Calabrese's opinion, is extremely significant. Using Calabrese's words, it shows once again what happens when some scientists actually try to understand the physical system and what happens within it, while others are simply dismissive. In this context, there are a few more points I want to mention here that deserve particular consideration. Two important sets of experiments have been reported in the last few years. The first concerns the above-mentioned studies by the Bellare group using electron diffraction and electron transmission microscopy techniques. 4,5 These studies show that, contrary to any previous beliefs, when homeopathic medicines containing metal nanoparticles are progressively diluted and succussed, highly diluted solutions contain an unexpected amount of the original substance. According to the authors, this is due to the formation of an enriched monolayer of nanoparticles on the surface due to froth flotation induced by succussion, that is, a particular vigorous shaking procedure. This

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Hormetic use of stress in gerontological interventions requires a cautious approach

Jargin

2015

Biogerontology

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Hormesis as a general principle is conceivable only for factors that are present in the natural environment. For such factors, existence of an optimal level can be assumed, which would correspond to the current environmental level or some average of historic levels. Theoretic basis of some hormetic mechanisms has been discussed within the scope of stress response pathways. Impacts of multiple stressing agents may produce combined effects larger than those expected from isolated impacts i.e. act synergistically. Adding the effect of a damaging stress to another damaging stress would possibly augment the damage; but if two mild stresses have positive hormetic effects, their combination can have additive positive effects. Potential adverse effects of excessive doses of hormetic agents should be pointed out particularly for senile age or a state close to decompensation when minor stimuli might be damaging. In conclusion, a hormetic use of stress in gerontological interventions requires a cautious approach.

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Hormesis

Cited by 6 publications

References 19 publications

Radiation Safety and Hormesis

Radiation Safety and Hormesis

Hormesis and Homeopathy: Toward a New Self-Consciousness

Hormetic use of stress in gerontological interventions requires a cautious approach

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