Hormesis and Aging

Rattan, Suresh I. S.; Demirovic, Dino

doi:10.1007/978-1-60761-495-1_9

Cited by 55 publications

(79 citation statements)

References 143 publications

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“…It has been hypothesized that exposure to mild stressors activates homeodynamic pathways of maintenance and repair triggering beneficial effects on brain functions 24 . Indeed, although high levels or chronic stress have been associated with reduced synaptic plasticity in the hippocampus, a mild or acute stress has been demonstrated to increase LTP induction 25 .…”

Section: Corticosterone Mimics Fr Effects On Visual Cortex Plasticitymentioning

confidence: 99%

Food restriction enhances visual cortex plasticity in adulthood

Spolidoro¹,

Baroncelli²,

Putignano

et al. 2011

Nat Commun

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neural circuits display a heightened sensitivity to external stimuli during well-established windows in early postnatal life. After the end of these critical periods, brain plasticity dramatically wanes. The visual system is one of the paradigmatic models for studying experiencedependent plasticity. Here we show that food restriction can be used as a strategy to restore plasticity in the adult visual cortex of rats. A short period of food restriction in adulthood is able both to reinstate ocular dominance plasticity and promote recovery from amblyopia. These effects are accompanied by a reduction of intracortical inhibition without modulation of brainderived neurotrophic factor expression or extracellular matrix structure. our results suggest that food restriction could be investigated as a potential way of modulating plasticity.

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Section: Corticosterone Mimics Fr Effects On Visual Cortex Plasticitymentioning

confidence: 99%

Food restriction enhances visual cortex plasticity in adulthood

Spolidoro¹,

Baroncelli²,

Putignano

et al. 2011

Nat Commun

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show abstract

“…In fact, polymorphisms of the Nrf-2 encoding gene have been associated with endurance performance of athletes (He et al 2007;Eynon et al 2010). These adaptive responses to exercise and toxic insults are known as hormesis, a concept that increases cytoprotection and promotes longevity (Motta et al 2004;Rattan 2008a). In this regard, any natural or synthetic compound which activates a stress response resulting in positive effects is known as hormetin (Rattan 2008b).…”

Section: Tac In Aging and Detraining: Is The Lack Of Exercise The Orimentioning

confidence: 99%

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Ferrari

2011

Frontiers in Life Science

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The objective of this article was to review the biochemical basis of the total antioxidant capacity (TAC) test and its applications to exercise science and promotion of healthy aging. Measurement of TAC allows evaluation of the antioxidant content of muscle, heart and other exercise-target organs. Acute non-regular physical exercise and body exposition to higher altitude have been associated with a considerable decrease of blood TAC. However, regular practice of physical activity and exercise is associated with improved antioxidant response increasing TAC levels. TAC methodologies did not address lipophylic antioxidants and have some other limitations. However, TAC is useful as a complementary test for the evaluation of antiperoxidation assays and blood, erythrocyte and cytosolic antioxidant enzyme assays (glutathion reductase, glutathion peroxidase, superoxide dismutase and catalase). Exercise induces both molecular antioxidant and hormetic responses which have been suggested to be linked with a healthy aging.

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“…Hormesis in cells and organisms consists in a mild stressinduced stimulation of protective mechanisms resulting in biologically beneficial effects, and cell death being the final manifestation of the failure in adaptation or unsuccessful adaptation (1,2). Hormetic responses are induced by low doses of toxic agents, irradiation, and reactive oxygen species (ROS), in addition to dietary caloric restriction, moderate exercise, and heat stress (2)(3)(4)(5). Considering that hormesis is a dose-time-response in the low-dose range with beneficial characteristics, responses at high-dose ranges and/or after prolonged exposure to the stressor are potentially harmful (2,6).…”

Section: Introductionmentioning

confidence: 99%

“…Hormetic responses are induced by low doses of toxic agents, irradiation, and reactive oxygen species (ROS), in addition to dietary caloric restriction, moderate exercise, and heat stress (2)(3)(4)(5). Considering that hormesis is a dose-time-response in the low-dose range with beneficial characteristics, responses at high-dose ranges and/or after prolonged exposure to the stressor are potentially harmful (2,6). One such example is the oxidative stress phenomenon characterized by the imbalance in the pro-oxidant/antioxidant equilibrium in favor of the pro-oxidants (7), which triggers different types of responses depending on the cell type, the level of ROS achieved, and the duration of the exposure (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress

Videla

2010

IUBMB Life

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SummaryThyroid hormone (L-3,3 0 ,5-triiodothyronine, T 3 ) exerts calorigenic effects by accelerating mitochondrial O 2 consumption through transcriptional activation of respiratory genes, with consequent increased reactive oxygen species (ROS) production. In the liver, ROS generation occurs at different sites of hepatocytes and in the respiratory burst of Kupffer cells, triggering the activation of the transcription factors nuclear factor-jB, signal transducer and activator of transcription 3, and activating protein 1. Under these conditions, the redox upregulation of Kupffer cell-dependent expression of cytokines [tumor necrosis factor-a, interleukin (IL)-1, and IL-6] is achieved, which upon interaction with specific receptors in hepatocytes trigger the expression of antioxidant enzymes (manganese superoxide dismutase, inducible nitric oxide synthase), antiapoptotic proteins (Bcl-2), and acute-phase proteins (haptoglobin, b-fibrinogen). These responses and the promotion of hepatocyte and Kupffer cell proliferation observed represent hormetic effects re-establishing redox homeostasis, promoting cell survival, and protecting the liver against ischemia-reperfusion (IR) injury. It is proposed that hormesis underlying T 3 action may constitute a novel preconditioning strategy for IR injury during liver surgery in man or in liver transplantation using reduced-size grafts from living donors, considering that (i) with the exception of the controversial ischemic preconditioning, all other studied strategies have failed to reach the clinical setting and (ii) T 3 is a well-tolerated therapeutic agent that either lacks major adverse effects or has minimal and controlled side effects. IUBMBIUBMB Life, 62(6): [460][461][462][463][464][465][466] 2010

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Hormesis and Aging

Cited by 55 publications

References 143 publications

Food restriction enhances visual cortex plasticity in adulthood

Food restriction enhances visual cortex plasticity in adulthood

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress

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