2010
DOI: 10.2203/dose-response.09-014.vaiserman View full text |Buy / Rent full text
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Abstract: ᮀ Hormesis is a common phenomenon in a number of biomedical areas. However, the basic nature of this phenomenon remains largely unknown. Therefore, significant uncertainty is inevitable in attempts to apply hormesis as a pro-health and anti-aging tool. Evidence supporting that hormetic-like effects may be the result of a generalized wholeorganism adaptive epigenetic response is reviewed. Specific hormesis-inducing interventions during development would allow to achieve an optimal balance between activation and… Show more

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“…However, there is not enough information about its use in forestry. Although little is known about the basic nature of this phenomenon, Vaiserman (2010) had indicated the possible relationship between the hormesis and epigenetic effects. The application of low-dose ionizing radiation could produce in coniferous species hormetics radiostimulants effects through genetic and epigenetic changes that manifest as adaptive responses.…”
Section: Introductionmentioning
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“…However, there is not enough information about its use in forestry. Although little is known about the basic nature of this phenomenon, Vaiserman (2010) had indicated the possible relationship between the hormesis and epigenetic effects. The application of low-dose ionizing radiation could produce in coniferous species hormetics radiostimulants effects through genetic and epigenetic changes that manifest as adaptive responses.…”
Section: Introductionmentioning
“…All authors of this issue were of the opinion that mild stress could be used in human beings, even if they wondered how and when using it to get the best effects. Particularly, one of the problems is ''when'' (Kahn and Olsen 2010;Pardon 2010;Vaiserman 2010). In the event a mild stress improving health span were discovered, would it be necessary to apply it at young age, at old age, or throughout life?…”
Section: Introductionmentioning
“…The discrete nanomedicine dose constitutes the pulsed input signal. The result is resistance or cross-resistance (adaptation or cross-adaptation) to same or similar biological stressor or injury, whether they already have occurred or might occur at higher intensities in the future [97][98][99][100][101].…”
Section: Endogenous Amplification Phenomena In Complex Adaptive Systemsmentioning
“…However, the direction of change from adaptation to a low dose that the organism can survive instead enhances resistance against the adverse effects of the same agent [97,98,[103][104][105]. Furthermore, such beneficial changes can modify responses to not only the same, but also a cross-adapted agent or stressor.…”
Section: Impact After 1 Hour On Injury-related Edema Compared With Samentioning
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