Hormesis, Adaptive Epigenetic Reorganization, and Implications for Human Health and Longevity

Vaiserman, Alexander

doi:10.2203/dose-response.09-014.vaiserman

Cited by 47 publications

(46 citation statements)

References 31 publications

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“…However, there is not enough information about its use in forestry. Although little is known about the basic nature of this phenomenon, Vaiserman (2010) had indicated the possible relationship between the hormesis and epigenetic effects. The application of low-dose ionizing radiation could produce in coniferous species hormetics radiostimulants effects through genetic and epigenetic changes that manifest as adaptive responses.…”

Section: Introductionmentioning

confidence: 99%

Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species

Iglesias-Andreu¹,

Octavio‐Aguilar²,

Bello-Bello³

2012

Gamma Radiation

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Section: Introductionmentioning

confidence: 99%

Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species

Iglesias-Andreu¹,

Octavio‐Aguilar²,

Bello-Bello³

2012

Gamma Radiation

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“…All authors of this issue were of the opinion that mild stress could be used in human beings, even if they wondered how and when using it to get the best effects. Particularly, one of the problems is ''when'' (Kahn and Olsen 2010;Pardon 2010;Vaiserman 2010). In the event a mild stress improving health span were discovered, would it be necessary to apply it at young age, at old age, or throughout life?…”

Section: Introductionmentioning

confidence: 99%

A cold stress applied at various ages can increase resistance to heat and fungal infection in aged Drosophila melanogaster flies

Bourg¹

2010

Biogerontology

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A cold stress applied to young flies can have positive effects on longevity, behavioral aging, and resistance to heat and infection. However, the same mild stress, if applied at older ages, i.e. in frailer flies, could be a strong stress with negative effects. Cold stress was applied at various ages (weeks 1-2, 2-3, 3-4, and 4-5) and its effect on longevity and on resistance at 6 weeks of age to heat or fungal infection was observed. In males, the cold stress had positive effects on longevity and resistance to infection, except when applied at the oldest age. No positive effect on longevity or resistance to infection was detected in cold-stressed females, as already observed in previous experiments using a cold stress at young age only. By contrast, cold stress applied at various ages increased resistance to heat in both sexes. Therefore, a mild stress can have positive effects on longevity and resistance to strong stresses not only when used at a young age, but also at older ages.

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Section: Endogenous Amplification Phenomena In Complex Adaptive Systemsmentioning

confidence: 99%

“…However, the direction of change from adaptation to a low dose that the organism can survive instead enhances resistance against the adverse effects of the same agent [97,98,[103][104][105]. Furthermore, such beneficial changes can modify responses to not only the same, but also a cross-adapted agent or stressor.…”

Section: Impact After 1 Hour On Injury-related Edema Compared With Samentioning

confidence: 99%

“…The discrete nanomedicine dose constitutes the pulsed input signal. The result is resistance or cross-resistance (adaptation or cross-adaptation) to same or similar biological stressor or injury, whether they already have occurred or might occur at higher intensities in the future [97][98][99][100][101].The purpose of homeopathic treatment is not to force a specific change in a single target tissue with continuous dosing, in the manner of a conventional bulk form drug. Instead, the intent is to stimulate a cascade of multiple systemic adaptations around the network, all set into motion by the original salient stimulus of a discrete low dose of specific NPs [21].…”

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confidence: 99%

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Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Bell

Sarter

Koithan

et al. 2013

J Nanomed Nanotechol

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The purpose of the present paper is (a) to outline the self-organized, complex adaptive network nature of the organism as recipient of nanomedicines; (b) to propose several nonlinear endogenous amplification processes by which pulsed low doses of traditional, homeopathically-manufactured natural product nanomedicines may stimulate a return toward healthier function; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. Homeopathy is an over 200-year-old system of complementary and alternative medicine (CAM) that uses low doses of natural plant-, mineral-, and animal-sourced nanomedicines. Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. Agitation within glass containers at room temperature may also contribute nanosilica and nanosilicon as drug delivery vehicles and biological amplifiers. The medicine selection is matched to the recipient organism's systemic patterns of dysfunction and pulsed in the timing of the discrete doses. Endogenous amplification processes within the recipient organism may involve hormesis, time-dependent sensitization, and/or stochastic resonance. Effects are adaptive and systemically diffuse, i.e., causally indirect, rather than pharmacological and local, i.e., direct. All of these nonlinear response processes require interaction of the nanoparticle (NP) dose with the organism as a complex adaptive system. The pulsed NP dose serves as a low intensity salient danger signal for the organism to make network-wide adaptive changes that can lead to healing. The historically safe therapeutic approach of homeopathic nanomedicine dosing avoids risks of high, continuous doses and cumulative toxicity that contemporary nanomedicine researchers are now trying to solve while using NPs as if they were conventional bulk drugs. Integrating the insights, technical procedures, and clinical dosing approaches from modern and homeopathic nanomedicine could lead to major advances in the field for more effective and safer translational applications.NPs in homeopathic medicines [3]. NP concentrations are low, but measurable [3]. Like modern manufactured NPs [13], homeopathicallymanufactured medicines in solution also can exhibit aging effects [9,14]. These nanomedicines are delivered either in ethanolic liquids or sprayed and dried onto lactose or lactose/sucrose pellets for oral administration.Homeopathic manufacturing materials and methods are inherently "green" [15,16]. Previous papers have addressed the striking similarities between modern top-down mechanical attrition procedures for making nanoparticles (NPs) [17] and historical homeopathic medicine manufacturing methods and materials [15,[18][19][20][21]. These similarities include mechanically grinding source materials in lactose for hours and repeatedly agitating ethanol-water solutions containing the source Citation: Bell IR, Sarter B, Koithan M, Standish LJ, Banerji P, et al. (2013) Nonlinea...

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Hormesis, Adaptive Epigenetic Reorganization, and Implications for Human Health and Longevity

Cited by 47 publications

References 31 publications

Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species

Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species

A cold stress applied at various ages can increase resistance to heat and fungal infection in aged Drosophila melanogaster flies

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

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