Horizontal glottectomy: is it an out-of-date procedure?

Alicandri‐Ciufelli, Matteo; Molteni, Gabriele; Mattioli, Francesco; Bergamini, Giuseppe; Tassi, Sauro; Monzani, Daniele; Presutti, Livio; D'Angeli, Ilaria; Izzo, Paolo; Izzo, Luciano

doi:10.1016/j.amjoto.2010.11.016

Cited by 3 publications

(10 citation statements)

References 16 publications

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“…According to Silver et al there has been a decline of open larynx surgeries performed in early glottic cancer, however, external procedures are still utilized . The authors want to focus on a group of T1b glottic cancer patients with the anterior commissure (AC) involvement.…”

Section: Introductionmentioning

confidence: 99%

“…It is a segmental resection of the glottis performed by 2 horizontal incisions: the lower through the cricothyroid membrane and the upper across the wings of the thyroid cartilage. The resulting defect is closed by approximating the cricoid to the thyroid remnants (cricothyropexy) . The procedure, while quite effective for treatment of bilateral and anterior commissure lesions, has never gained general acceptance in the United States .…”

Section: Introductionmentioning

confidence: 99%

“…According to Silver et al 1 there has been a decline of open larynx surgeries performed in early glottic cancer, however, external procedures are still utilized. [2][3][4] The authors want to focus on a group of T1b glottic cancer patients with the anterior commissure (AC) involvement. The primary treatment of AC carcinoma was widely described in 2006 by Bradley et al 5 : radiotherapy, open partial surgery, and endoscopic partial surgery were discussed.…”

Section: Introductionmentioning

confidence: 99%

“…The resulting defect is closed by approximating the cricoid to the thyroid remnants (cricothyropexy). 2,8 The procedure, while quite effective for treatment of bilateral and anterior commissure lesions, has never gained general acceptance in the United States. 8 In the authors' clinical practice, lesions with anterior commissure involvement had never been qualified for TLM and only few patients were selected for primary XRT.…”

Section: Introductionmentioning

confidence: 99%

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Value of open horizontal glottectomy in the treatment for T1b glottic cancer with anterior commissure involvement

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Value of open horizontal glottectomy in the treatment for T1b glottic cancer with anterior commissure involvement

et al. 2013

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“…Twenty‐six (48.1%) patients underwent total laryngectomy, whereas the remaining 28 (51.9%) were treated by partial laryngectomy, in particular OPHL type 1, 2, 3 3 and horizontal glottectomy. 11 , 12 The distribution of the enrolled patients according to the treatment choice is resumed in Table II .…”

Section: Resultsmentioning

confidence: 99%

pT3 N0 Laryngeal Squamous Cell Carcinoma: Oncologic Outcomes and Prognostic Factors of Surgically Treated Patients

et al. 2021

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Objectives/Hypothesis: To assess the disease control, survival rates, and prognostic factors of exclusive surgical treatment for patients with pT3 N0 laryngeal squamous cell carcinoma (LSCC).Study Design: Multicentric retrospective cohort study. Methods: Multicentric retrospective case series of previously untreated patients with pT3 R0N0 LSCC, who received exclusive surgery between 2011 and 2019. Tumor location; subsite involvement; grading; and lymphatic, vascular, and perineural invasion were reported. Overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were measured.Results: Fifty-four patients (mean age 67.1; male sex 83.3%; mean follow-up period 37 months) underwent total laryngectomy (48.1%) or partial laryngectomy (51.9%). Ipsilateral or bilateral neck dissection was performed in 46 (85.2%) cases. Perineural invasion was more frequent in case of supraglottic involvement than glottic involvement (85.7% vs. 14.3%, P = .03). Five (9.3%) patients experienced recurrence (3 local recurrences, 1 nodal recurrence, 1 distant recurrence). Rate of recurrence differed between glottic (0%), supraglottic (80%), and transglottic (20%) tumors (P = .01), with a lower risk yielded by glottic involvement (odds ratio [OR], 0.05, 95% confidence interval [95% CI], 0.01-0.56, P = .01). A higher risk was recorded in case of perineural invasion (OR, 66.0, 95% CI, 1.41-3085.3, P = .03). The OS, DSS, and DFS were 79.6%, 96.3%, and 90.7%, without differences regarding the type of surgery. The DFS was lower in case of supraglottic involvement when compared to purely glottic LSCC (83.9% vs. 100%, P = 0.02).Conclusions: Exclusive surgery is a safe option for patients with pT3 R0N0 LSCC. Adjuvant treatments or closer followup monitoring might be considered in case of supraglottic involvement or perineural invasion.

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Oncological and Functional Outcomes for Horizontal Glottectomy: A Systematic Review

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Manto

Lotto

et al. 2023

JCM

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Horizontal glottectomy (HG) is a particular type of partial laryngectomy indicated for exclusive glottic tumor with anterior commissure involvement. The purpose of this study is to systematically review the literature about functional and oncological outcome of HG. This systematic review adhered to the recommendations of the PRISMA (Preferred Reporting Items of Systematic Reviews and Meta-analysis) 2009 guidelines. Articles mentioning patients undergoing HG for laryngeal squamous cell carcinoma were included. A total of 14 articles were selected and reviewed from 19 identified. The whole study population consisted of 420 patients who underwent HG. Three hundred and thirty-nine patients out of 359 were staged as T1. The range of post-operative follow-up was 5 months to 10 years. Fifty-five recurrences were experienced, being local, regional and distant in 35, 12 and 8 patients, respectively. Laryngeal preservation rate was 93.6%. Nasogastrict tube was removed on average after 10.1 days. The tracheostomy was maintained for 11.3 days. Mean hospitalization lasted for 11.7 days. According to the results of this systematic review, HG is an oncologically safe surgical option for T1a–T1b glottic tumors with oncological outcomes comparable to other treatment. HG could be a good therapeutical choice whenever poor laryngeal exposure and/or patient’s refusal of radiotherapy are encountered, or when patient’s medical history represents a contraindication for radiation therapy.

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Horizontal glottectomy: is it an out-of-date procedure?

Cited by 3 publications

References 16 publications

Value of open horizontal glottectomy in the treatment for T1b glottic cancer with anterior commissure involvement

Value of open horizontal glottectomy in the treatment for T1b glottic cancer with anterior commissure involvement

pT3 N0 Laryngeal Squamous Cell Carcinoma: Oncologic Outcomes and Prognostic Factors of Surgically Treated Patients

Oncological and Functional Outcomes for Horizontal Glottectomy: A Systematic Review

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