Horizontal gene transfer in schistosomes: A critical assessment

Wijayawardena, Bhagya K.; Minchella, Dennis J.; DeWoody, J. Andrew

doi:10.1016/j.molbiopara.2015.05.008

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…The exact mechanisms of eukaryotic HT are unknown, though host-parasite interactions are among the main known gateways 32 . It is possible that HT in eukaryotic genomes is more common than currently appreciated with more evidence emerging from the rapidly expanding genomic and transcriptomic data 34 , 35 . Unique male-specific ampliconic testes-expressed sequences have been identified in every Y chromosome studied this far, yet their origin has remained puzzling.…”

Section: Resultsmentioning

confidence: 99%

Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes

et al. 2018

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Dynamic evolutionary processes and complex structure make the Y chromosome among the most diverse and least understood regions in mammalian genomes. Here, we present an annotated assembly of the male specific region of the horse Y chromosome (eMSY), representing the first comprehensive Y assembly in odd-toed ungulates. The eMSY comprises single-copy, equine specific multi-copy, PAR transposed, and novel ampliconic sequence classes. The eMSY gene density approaches that of autosomes with the highest number of retained X–Y gametologs recorded in eutherians, in addition to novel Y-born and transposed genes. Horse, donkey and mule testis RNAseq reveals several candidate genes for stallion fertility. A novel testis-expressed XY ampliconic sequence class, ETSTY7, is shared with the parasite Parascaris genome, providing evidence for eukaryotic horizontal transfer and inter-chromosomal mobility. Our study highlights the dynamic nature of the Y and provides a reference sequence for improved understanding of equine male development and fertility.

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Section: Resultsmentioning

confidence: 99%

Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes

et al. 2018

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“…Far less spectacular results reporting about 0.5% LGT for the same tardigrade tend more accurately to reflect nature's workings, but 0.5% is still way too much eukaryote LGT. Even the highly touted observations suggesting LGT in rotifers have found more sobering explanations, while LGT claims in schistosomes fail under critical inspection . In the face of pressure to publish evolutionary insights from genomic investigations – symptomatically when no other storyline is readily found in a given set of genome data – have evolutionary biologists become uncritical?…”

Section: Discussionmentioning

confidence: 99%

Too Much Eukaryote LGT

Martin

2017

BioEssays

116

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The realization that prokaryotes naturally and frequently disperse genes across steep taxonomic boundaries via lateral gene transfer (LGT) gave wings to the idea that eukaryotes might do the same. Eukaryotes do acquire genes from mitochondria and plastids and they do transfer genes during the process of secondary endosymbiosis, the spread of plastids via eukaryotic algal endosymbionts. From those observations it, however, does not follow that eukaryotes transfer genes either in the same ways as prokaryotes do, or to a quantitatively similar degree. An important illustration of the difference is that eukaryotes do not exhibit pangenomes, though prokaryotes do. Eukaryotes reveal no detectable cumulative effects of LGT, though prokaryotes do. A critical analysis suggests that something is deeply amiss with eukaryote LGT theories.

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