High-rise buildings are highly sensitive to horizontal loads. Therefore, any changes made to the arrangement, size, or shape of the shear walls will have significant effects on the strength and performance of the building. In this article, the author conducted an investigation on specific cases: walls located at the corner of the building, walls present in both directions, and reinforced concrete frames. The results of the analysis suggest that changing the placement of walls located at the four corners of the structure will significantly influence the bending moment, shear force, and axial force observed at the base of the columns. At the same time, it also affects the top displacement based on the direction of the main bearing of the structure. The survey results include diagrams showing the bending moment, the shear force, and the axial force in the main frame of the building. These values are then compared with each other at BoC in the main frame. It is evident that the bending moment and shear force values for Case 1 and Case 3 are significantly lower compared to Case 2. This suggests that Case 1 and Case 3 are the most favorable options for calculating and designing the structure of this high-rise building.