The topic of this review is the particle astrophysics of high energy neutrinos. High energy is defined as E ν > 100 MeV. Main topics include: -atmospheric neutrinos and muons from π, K and charm decay. They probe uncharted territory in neutrino oscillations and constitute both the background and calibration of high energy neutrino telescopes, -sources of high energy neutrino beams: the galactic plane, the sun, X-ray binaries, supernova remnants and interactions of extra-galactic cosmic rays with background photons, -an extensive review of the mechanisms by which active galaxies may produce high energy particle beams, -high energy neutrino signatures of cold dark matter and, -a brief review of detection techniques (water and ice Cherenkov detectors, surface detectors, radio-and acoustic detectors, horizontal airshower arrays) and the instruments under construction.