Hopper Flow Electrostatics of Tableting Material I

Gold, Gerald; Palermo, Blaze T.

doi:10.1002/jps.2600540233

Cited by 21 publications

(3 citation statements)

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“…As such in many cases, particle charging has been found to decrease with increasing ambient relative humidity (RH) 75,106,107 . It has been suggested that moisture can reduce the surface contact, change the conductivity or other bulk properties of the particles, and hence facilitate charge neutralization.…”

Section: Relative Humiditymentioning

confidence: 98%

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik

Mukherjee

Chaudhuri

2016

International Journal of Pharmaceutics

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Section: Relative Humiditymentioning

confidence: 98%

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik

Mukherjee

Chaudhuri

2016

International Journal of Pharmaceutics

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“…A limited study of the development of static charges with different particle size granules of varying moisture content has been made (Gold and Palermo, 1965).…”

Section: Flow Of Granules Within the Hoppermentioning

confidence: 99%

Problems of powder flow in tabletting processes

Hersey

1965

Rheol Acta

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“…Thus, phenomena such as the surface exchange of charged species (i.e., electrons, ions, material fragments, or combinations thereof), known as tribo-charging, can develop more easily [14]. Powder tribo-charging has been suggested as a potential root cause for inaccuracy and inconsistency of the feeding process [15][16][17], the (fore)most critical step inherent to all CM processes [18]. Therefore, there is a growing interest in characterizing the tribo-charging tendency of powders as a critical material attribute for feeding performance [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders

et al. 2023

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Tribo-charging is often a root cause of mass flow deviations and powder adhesion during continuous feeding. Thus, it may critically impact product quality. In this study, we characterized the volumetric (split- and pre-blend) feeding behavior and process-induced charge of two direct compression grades of polyols, galenIQ™ 721 (G721) for isomalt and PEARLITOL® 200SD (P200SD) for mannitol, under different processing conditions. The feeding mass flow range and variability, hopper end fill level, and powder adhesion were profiled. The feeding-induced tribo-charging was measured using a Faraday cup. Both materials were comprehensively characterized for relevant powder properties, and their tribo-charging was investigated for its dependence on particle size and relative humidity. During split-feeding experiments, G721 showed a comparable feeding performance to P200SD with lower tribo-charging and adhesion to the screw outlet of the feeder. Depending on the processing condition, the charge density of G721 ranged from -0.01 up to -0.39 nC/g, and for P200SD from -3.19 up to -5.99 nC/g. Rather than differences in the particle size distribution of the two materials, their distinct surface and structural characteristics were found as the main factors affecting their tribo-charging. The good feeding performance of both polyol grades was also maintained during pre-blend feeding, where reduced tribo-charging and adhesion propensity was observed for P200SD (decreasing from -5.27 to -0.17 nC/g under the same feeding settings). Here, it is proposed that the mitigation of tribo-charging occurs due to a particle size-driven mechanism. Graphical abstract

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Hopper Flow Electrostatics of Tableting Material I

Cited by 21 publications

References 0 publications

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Problems of powder flow in tabletting processes

Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders

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