Hopper Flow Electrostatics of Tableting Material II

Effect of Concentration and Size of Lubricant on Flow Rate of Granules

“…Again the flow rate was decreased as the concentration of the stearic acid was increased to 0.2%; as the concentration was increased to 0.5 % stearic acid, the maximum flow rate was attained. An electrostatic effect was observed on the stearic acid particles and was assumed to be responsible for this variation (13). The action of lubricants has been studied from the viewpoint of concentration, but apparently no research has been reported concerning the influence of size of the lubricant on flowability.…”

Tabletler Ve Tablet Basimina Etki Eden Kuvvetlerin Belirlenmesinde Kullanilabilecek Bazi Yeni Esitlikler

“…(20). Lubrikantlar tablet üretiminde gerçekleştirilen temel işlemlerde toz partiküller arasındaki sürtünmeyi azaltarak glidant gibi toz akışını iyileştirebilirler, kütlenin zımbaya yapışmasını engellerler ve tabletlerin mührede ve zımbada sıkışmasını minimuma indirgerler (21,22). Lubrikantlar, tablet granülasyonu esnasında formülasyona ilave edildiklerinde, granüller etrafında tabaka oluşturmaktadır.…”