Hope for vascular cognitive impairment: Ac-YVAD-cmk as a novel treatment against white matter rarefaction
Yun-An Lim,
Li Si Tan,
Wei Thye Lee
et al.
Abstract:Vascular cognitive impairment (VCI) is the second leading cause of dementia with limited treatment options, characterised by cerebral hypoperfusion-induced white matter rarefaction (WMR). Subcortical VCI is the most common form of VCI, but the underlying reasons for region susceptibility remain elusive. Recent studies employing the bilateral cortical artery stenosis (BCAS) method demonstrate that various inflammasomes regulate white matter injury and blood-brain barrier dysfunction but whether caspase-1 inhibi… Show more
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