Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

Cançado, Guilherme Grossi Lopes; Fiuza, Jacqueline Araújo; Paiva, Nívia Carolina Nogueira de; Lemos, Lucas de Carvalho Dhom; Ricci, Natasha Delaqua; Gazzinelli-Guimarães, Pedro Henrique; Martins, Virgillio Gandra; Bartholomeu, Daniella Castanheira; Negrão-Corrêa, Déborah; Carneiro, Cláudia Martins; Fujiwara, Ricardo Toshio

doi:10.1002/ibd.21629

Cited by 87 publications

(74 citation statements)

References 69 publications

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“…A growing body of literature suggests that much of this protection against inflammation is mediated by soluble molecules released by the parasites. Some examples include protection in the dinitrobenzene sulfonic acid (DNBS) model of colitis utilizing soluble somatic extracts from Trichinella spiralis (34) and Hymenolepis diminuta (35), as well as the use of ES products from Ancylostoma ceylanicum, a relative of A. caninum, in the DSS model of colitis (36). Furthermore, AcES and Schistosoma mansoni somatic proteins alleviated pathology associated with TNBSmediated colitis (22).…”

Section: Discussionmentioning

confidence: 99%

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺IL-10⁺CD4⁺T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺IL-10⁺CD4⁺T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

et al. 2013

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“…[104][105][106] It is tempting to speculate that immunomodulatory virulence factors, such as hookworm TIMPs, might indeed be these elusive molecules, and the development of recombinant proteins derived from these agents might unlock novel therapeutics for allergic and autoimmune disorders.…”

Section: Molecular Mechanisms Associated With Host Defense and Immunementioning

confidence: 99%

Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines

Pearson¹,

Tribolet²,

Cantacessi³

et al. 2012

Journal of Allergy and Clinical Immunology

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“…Indeed, a number of parasite-derived products have shown some protective ability in immunopathology models [16,17]. Products of Ancylostoma caninum [43,44] . We report below that co-administration of HES with sensitising allergen inhibits both innate and adaptive arms of the immune response, including eosinophilia, type 2 innate response markers, antibody generation and effector T-cell reactivity.…”

mentioning

confidence: 99%

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

McSorley

O'Gorman

Blair³

et al. 2012

Eur J Immunol

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Allergic asthma is less prevalent in countries with parasitic helminth infections, and mice infected with parasites such as Heligmosomoides polygyrus are protected from allergic airway inflammation. To establish whether suppression of allergy could be mediated by soluble products of this helminth, we tested H. polygyrus excretory-secretory (HES) material for its ability to impair allergic inflammation. When HES was added to sensitising doses of ovalbumin, the subsequent allergic airway response was suppressed, with ablated cell infiltration, a lower ratio of effector (CD4 + CD25 + Foxp3 − ) to regulatory (CD4 + Foxp3 + ) T (Treg) cells, and reduced Th1, Th2 and Th17 cytokine production. HES exposure reduced IL-5 responses and eosinophilia, abolished IgE production and inhibited the type 2 innate molecules arginase-1 and RELM-α (resistin-like molecule-α). Although HES contains a TGF-β-like activity, similar effects in modulating allergy were not observed when administering mammalian TGF-β alone. HES also protected previously sensitised mice, suppressing recruitment of eosinophils to the airways when given at challenge, but no change in Th or Treg cell populations was apparent. Because heat-treatment of HES did not impair suppression at sensitisation, but compromised its ability to suppress at challenge, we propose that HES contains distinct heat-stable and heat-labile immunomodulatory molecules, which modulate pro-allergic adaptive and innate cell populations.Keywords: Allergy r Eosinophils r IgE r Infection r Macrophages IntroductionAllergic asthma has dramatically increased in prevalence in developing countries, exceeding 5% of the Western European and North American populations [1]. This contrasts with much lower asthma incidence in tropical countries that have significant levels of parasite infections, and these observations have stimulated research into the effects of parasitic organisms on human allergy [2][3][4]. From these studies, it has emerged that allergic diseases are least common in parts of the world with high helminth endemicity, and that within endemic populations the prevalence of atopy is significantly lower in individuals with chronic worm infections [5][6][7][8][9][10].Correspondence: Dr. Rick M. Maizels e-mail: rick.maizels@ed.ac.ukWhile a causal link between human helminth infections and reduced allergy has yet to be proven [2], chemotherapeutic clearance of intestinal helminths can result in accentuated atopic responsiveness [11][12][13] and helminth infection blocks overt allergy in a number of animal models [14][15][16][17]. The degree to which helminths may influence allergy, however, is clearly variable between different parasite species [18], and is probably dependent upon the duration and intensity of infection [2,19], each factors that need to be taken into account in assessing this interaction.The concept that helminths may act in a beneficial way for therapy of immunological disorders is one that has been gaining * These author contributed equally to this work. Eur. J. Immunol. 20...

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Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

Cited by 87 publications

References 69 publications

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺IL-10⁺CD4⁺T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺IL-10⁺CD4⁺T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

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Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

Cited by 87 publications

References 69 publications

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+IL-10+CD4+T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+IL-10+CD4+T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

Contact Info

Product

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Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺IL-10⁺CD4⁺T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺IL-10⁺CD4⁺T Cell Responses and Suppress Pathology in a Mouse Model of Colitis