Hookworm infection among patients with pulmonary tuberculosis: Impact of co-infection on the therapeutic failure of pulmonary tuberculosis

Hasanain, Ahmad Farooq Alsayed; Zayed, Ali Abdel-Azeem Hasan; Mahdy, Reem Ezzat; Nafee, Amany Mohamed Adawi; Attia, Rasha Abdel-Monem Hassan; Mohamed, Asmaa

doi:10.1016/j.ijmyco.2015.09.002

Cited by 15 publications

(14 citation statements)

References 28 publications

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“…Our finding was high compared to a report in Egypt (16%) 9 and China (21.7%). 48 The Egyptian study 9 was only assessed the burden of a single parasite, which was not a dominant parasite in our finding. In our study, Ascaris lumbricoides was the dominant parasite.…”

Section: Discussioncontrasting

confidence: 82%

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Intestinal parasites and HIV in Ethiopian tuberclosis patients: A systematic review and meta-analysis

Dessie

Negesse

Wagnew

et al. 2020

Current Therapeutic Research

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Background The distribution of intestinal parasites among patients with tuberculosis in Ethiopia is not well understood. Objective This systematic review and meta-analysis was designed to determine the pooled national prevalence of intestinal parasites and its association with HIV among patients with tuberculosis in Ethiopia. Methods Original articles were searched in PubMed, Google Scholar, EMBASE, World Health Organization's HINARI portal, and supplemented by the hand searching of cross-references. Data were extracted using a standard data extraction checklist. Random-effects model was used to estimate the pooled prevalence of intestinal parasites and odds ratio of the association. The I 2 statistic was utilized to quantify statistical heterogeneity across studies. Funnel plot asymmetry and Egger regression tests were used to check for publication bias. The analysis was done by STATA version 14 for Windows. Results Of 725 identified studies, 12 articles were eligible for inclusion in the final analysis. The pooled national prevalence of intestinal parasites among patients with tuberculosis in Ethiopia was 36.1% (95% CI, 22.1–50.1; I 2 = 98.7%). Subgroup analysis based on study design indicated that the prevalence of intestinal parasite among case-control studies was 41.69% (95% CI, 28.6–54.8; I 2 = 95.1%). The odds of intestinal parasites among patients with tuberculosis–HIV coinfection was not significantly different compared with patients with tuberculosis without HIV/AIDS (odds ratio = 0.99; 95% CI, 0.7—4.7; P = 0.96). Conclusions In Ethiopia, at least 1 out of 3 patients with tuberculosis have an intestinal parasite. These findings suggest a need of more attention on increasing screening tuberculosis patients for intestinal parasites and deworming interventions. ( Curr Ther Res Clin Exp . 2020; 81:XXX–XXX)

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Section: Discussioncontrasting

confidence: 82%

“…7 In Africa, one-third of TB patients have an IPI 8 that contributes to the high rate of therapeutic failure of pulmonary TB. 9 …”

Section: Introductionmentioning

confidence: 99%

Intestinal parasites and HIV in Ethiopian tuberclosis patients: A systematic review and meta-analysis

Dessie

Negesse

Wagnew

et al. 2020

Current Therapeutic Research

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“…Among the 12 types of intestinal parasites identified, A.lumbricoides and H.worm were found to be the most frequently reported intestinal parasites. Likewise, studies from Tanzania [6] and Egypt [36] reported supportive findings. Among intestinal protozoans, G.lamblia was reported frequently compared with other intestinal protozoans.…”

Section: Discussionmentioning

confidence: 70%

Intestinal parasites co-infection among tuberculosis patients in Ethiopia: a systematic review and meta-analysis

2020

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Background: Tuberculosis and intestinal parasites are mostly affecting poor people. They are in a vicious since one is the risk factor for the other. However, the comprehensive report on the burden and coincidence of intestinal parasites and tuberculosis in Ethiopia is scant. This systematic review and meta-analysis aimed to provide abridge conclusive evidence on the intestinal parasite-tuberculosis co-infection in Ethiopia. Methods: A total of 414 articles published in English were searched from both electronic databases (CINAHL, DOAJ, Embase, Emcare, Medline, ProQuest, and PubMed, Science Direct, and Web of Science) and other sources. The qualities of the included studies were assessed using the Joanna Briggs Institute Critical Appraisal tools and the publication bias was measured using the funnel plot and Eggers regression test. Comprehensive meta-analysis (CMA) Version 3.3.07 and Review Manager software were used to estimate pooled prevalence and associations of intestinal parasites and tuberculosis infection. Results: Eleven articles with a total of 3158 tuberculosis patients included in the analysis based on the eligibility criteria. The estimated pooled prevalence of intestinal parasites co-infection was 33% (95% CI: 23.3, 44.3) using the random-effects model. The most common intestinal parasites were Ascaris lumbricoides 10.5% (95% CI: 6.0, 17.5), Hookworm 9.5% (95% CI: 6.10, 14.4), Giardia lamblia 5.7% (95% CI: 2.90, 10.9) and Strongyloides sterocoralis 5.6% (95% CI: 3.3, 9.5). The odds of intestinal parasites infection was higher among tuberculosis patients compared to tuberculosis free individuals (OR = 1.76; 95% CI: 1.17, 2.63). A significant difference was observed among TB patients for infection with intestinal helminths (OR = 2.01; 95% CI: 1.07, 3.80) but not for intestinal protozoans when compared with their counterparts. The odds of multiple parasitic infections was higher among tuberculosis patients (OR = 2.59, 95% CI: 1.90, 3.55) compared to tuberculosis free individuals. However, intestinal parasites co-infection was not associated with HIV status among tuberculosis patients (OR = 0.97; 95% CI: 0.71, 1.32). Conclusion: One-third of tuberculosis patients are co-infected with one or more intestinal parasites, and they are more likely to be infected with intestinal helminths and multiple intestinal parasitic infections compared to TB free individuals. We recommend routine screening of tuberculosis patients for intestinal parasites. The effect of mass deworming on tuberculosis incidence would be important to be considered in future researches. Trial registration: Registered on PROSPERO with reference number ID: CRD42019135350.

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“…As shown in Fig 1, we found a total of 1594 papers following the initial search of databases, and after excluding duplicates and/or non-eligible papers, 20 articles had eligibility to be considered in the current systematic review and meta-analysis [9,12,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. The Kappa test between the reviewers showed interobserver agreement of 93.75%, which was considered to be an excellent result.…”

Section: Study Characteristicsmentioning

confidence: 99%

Are intestinal helminths playing a positive role in tuberculosis risk? A systematic review and meta-analysis

et al. 2019

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Background Co-infection of intestinal helminthic infections (IHIs) and tuberculosis (TB) has appeared as a public health issue, especially in developing countries. Some recent studies have been carried out on the possible relevance of IHIs to TB. The current systematic review and metaanalysis was conducted to assess the prevalence and odds ratio (OR) of IHIs among TB patients and clarify the relationship between IHIs and TB disease. Methods For the purpose of the study, five English databases including PubMed, Science Direct, Scopus, Web of Science (ISI), and Google scholar were searched (up to January 30, 2019) in order to find the related studies. Random-effects meta-analysis model was used to estimate the pooled prevalence, odds ratio (OR), and 95% confidence interval (CI). Inclusion and exclusion criteria were applied. Results A total of 20 studies including 10 studies with case-control design (2217 patients and 2520 controls) and 10 studies with cross-sectional design (a total of 2415 participants) met the eligibility criteria. As shown by the random-effects model, the pooled prevalence of IHIs in TB patients was estimated to be 26% (95% CI, 17-35%; 1249/4632). The risk of IHI was higher in TB patients compared to controls but this was not statistically significant. However, according to genus/species, the pooled OR of Strongyloides stercoralis (S. stercoralis) (OR, 2.68; 95% CI, 1.59-4.54) had a significantly higher risk in TB patients compared to controls.

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Hookworm infection among patients with pulmonary tuberculosis: Impact of co-infection on the therapeutic failure of pulmonary tuberculosis

Cited by 15 publications

References 28 publications

Intestinal parasites and HIV in Ethiopian tuberclosis patients: A systematic review and meta-analysis

Intestinal parasites and HIV in Ethiopian tuberclosis patients: A systematic review and meta-analysis

Intestinal parasites co-infection among tuberculosis patients in Ethiopia: a systematic review and meta-analysis

Are intestinal helminths playing a positive role in tuberculosis risk? A systematic review and meta-analysis

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