Hookworm infection aggravates metabolic disorder in obesity

Silva, Vivian Jordania da; Dias, Sílvia Regina Costa; Alves, William Pereira; Furtado, Luis Fernando Viana; Serafim, Luciana Ribeiro; Moreira, Thayse Batista; Aguiar, Pedro Henrique Nascimento; Faria, Ana Maria Caetano; Rabelo, Élida Mara Leite

doi:10.1016/j.molbiopara.2019.111200

Cited by 6 publications

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ancylostoma ceylanicum, primarily described as a dog and cat nematode, is highly prevalent in humans in Southeast Asia, including Malaysia and Indonesia 30 . Although it has been consistently used as an experimental model for studies in Brazil 31,32 , A. ceylanicum has never been described in animal or human populations in this country. However, the migratory flow of tourists and workers to Brazil observed in recent decades must be carefully analyzed, since this migration has already been responsible for introducing A. ceylanicum species to countries in which it had not been previously described 33 .…”

Section: Discussionmentioning

confidence: 99%

Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine

Furtado

Dias

Rodrigues

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Hookworms are intestinal parasites that cause major public health problems, especially in developing countries. To differentiate eggs from different hookworm species, it is necessary to use molecular methodologies, since the eggs are morphologically similar. Here, we performed the molecular identification of single hookworm eggs from six Brazilian states. Of the 634 eggs individually analyzed, 98.1% (622/634) represented Necator americanus, and surprisingly, 1.9% (12/634 eggs from the same patient) represented Ancylostoma caninum. DnA analysis of the A. caninum-positive stool sample revealed no contamination with animal feces. This is the first report of the presence of A. caninum eggs in human feces, which may have a direct implication for the epidemiology of hookworm infection caused by this species. This suggests the need for special attention regarding prophylaxis, as different reservoirs, previously not described, may have great relevance for the spread of A. caninum.

show abstract

Section: Discussionmentioning

confidence: 99%

Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine

Furtado

Dias

Rodrigues

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…ceylanicum infection in hamster models does contribute to accentuate weight loss in obese models, infection leads to an aggravation of the metabolic disorder. Obese animals infected showed enlargement of the spleen, accumulation of lipids in the liver and faeces and higher inflammation with elevated macrophage and neutrophil activation in adipose tissue 115 …”

Section: Hookworm Therapymentioning

confidence: 99%

Immunopathology and modulation induced by hookworms: From understanding to intervention

Magalhães

Passos

Fujiwara

et al. 2020

Parasite Immunology

View full text Add to dashboard Cite

Hookworm infection is considered the most prevalent human soil‐transmitted helminth infection affecting approximately 500 million people and accounting for 3.2 million disability‐adjusted life years lost annually. As with many other neglected tropical diseases, no international surveillance mechanisms that show accurate data on the prevalence of hookworm infection are in place, thus hindering strategies to control parasite transmission. In this review, we unravel the current knowledge in immunopathology and immunoregulation of hookworm infection and present discoveries in drug therapies based on the capability of hookworms to regulate inflammation to treat allergic, inflammatory and metabolic diseases. Additionally, we highlight potential vaccine development and treatments and propose avenues for further inquiry.

show abstract

“…It mainly causes iron deficiency anemia and malnutrition [ 4 – 7 ], leading to more serious consequences such as lethargy, impaired physical and cognitive development, and poor pregnancy outcomes [ 2 , 8 ]. Other consequences, such as obscure overt gastrointestinal bleeding [ 9 ] and metabolic disorder in obese individuals [ 10 ], were also reported. Of the two species, N .…”

Section: Introductionmentioning

confidence: 99%

National surveillance of hookworm disease in China: A population study

et al. 2022

View full text Add to dashboard Cite

Background Hookworm disease is endemic in China and is widespread globally. The disease burden to humans is great. Methods The study described the national surveillance of hookworm implemented in 31 provinces/autonomous regions/municipalities (P/A/Ms) of China in 2019. Each P/A/M determined the number and location of surveillance spots (counties). A unified sampling method was employed, and at least 1000 subjects were investigated in each surveillance spot. The modified Kato-Katz thick smear method was employed for stool examination. Fifty samples positive with hookworm eggs were cultured in each surveillance spot to discriminate species between A. duodenale and N. americanus. Twenty-five soil samples were collected from each surveillance spot and examined for hookworm larva. The 2019 surveillance results were analyzed and compared with that of 2016–2018. Results A total of 424766 subjects were investigated in 31 P/A/Ms of China in 2019, and the overall hookworm infection rate was 0.85% (3580/424766). The weighted infection and standard infection rates were 0.66% (4288357/648063870) and 0.67% (4343844/648063870), respectively. Sichuan province had the highest standard infection rate (4.75%) in 2019, followed by Chongqing (2.54%) and Hainan (2.44%). The standard infection rates of other P/A/Ms were all below 1%, with no hookworm detected in 15 P/A/Ms. The standard hookworm infection rate in the males and the females were 0.61% (2021216/330728900) and 0.71% (2267141/317334970), respectively, with a significant difference between different genders (χ2 = 17.23, P<0.0001). The highest standard hookworm infection rate (1.97%) was among age ≥ 60 years, followed by 45~59 years (0.77%), 15~44 years (0.37%), and 7~14 years (0.20%). The lowest standard infection rate was among the 0~6 years age group (0.12%). A significant difference was observed among different age groups (χ2 = 2 305.17, P<0.0001). The constitute ratio for N. americanus, A. duodenale, and coinfection was 78.70% (1341/1704), 2.03% (346/1704), and 1.00% (17/1704), respectively. The detection rate of hookworm larva from soil was 3.45% (71/2056). Conclusion The national surveillance showed that the hookworm infection rate has been decreasing annually from 2016 to 2019, and it is now below 1%. China has made significant progress in controlling hookworm. The national surveillance system is an important way to understand the endemic status and provide important information in this process and thus needs to be continually optimized.

show abstract

Hookworm infection aggravates metabolic disorder in obesity

Cited by 6 publications

References 67 publications

Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine

Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine

Immunopathology and modulation induced by hookworms: From understanding to intervention

National surveillance of hookworm disease in China: A population study

Contact Info

Product

Resources

About