“…It is important to note that the strain of mouse used for most of these studies has been C57BI/6 mice, which has a nonfunctional allele of Nramp1, a divalent metal (iron and manganese) transporter that renders them more susceptible to infections (Canonne-Hergaux et al, 1999; Fritsche et al, 2012; Loomis et al, 2014; Powell and Frelinger, 2017; Soe-Lin et al, 2009). In humans, clinical data support our findings that dietary iron supplementation provides beneficial outcomes, especially in developing countries where low iron status may be prevalent (Loukas et al, 2016; Mwangi et al, 2017; Oppenheimer, 1989, 1998, 2001). However in malaria endemic areas, iron supplementation was associated with a negative outcome for patients (Clark et al, 2014).…”