Honeycomb-Structured Films by Multifunctional Amphiphilic Biodegradable Copolymers: Surface Morphology Control and Biomedical Application as Scaffolds for Cell Growth

Zhu, Yingdan; Sheng, Ruilong; Luo, Ting; Li, Hui; Sun, Junqi; Chen, Shengdian; Sun, Wenyan; Cao, Amin

doi:10.1021/am200371c

Cited by 73 publications

(51 citation statements)

References 68 publications

(132 reference statements)

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“…Furthermore, since P3 possesses too much PDMAEMA, some droplets are still forced to coalesce, thus interconnected pores and irregular surface are formed. It has been reported that molecular hydrophilicity can affect the pore size and regularity of honeycomb fi lms in earlier studies; [ 6,12,14 ] however, to the best of our knowledge, it is the fi rst time that molecular hydrophilicity has been found to play a crucial role in the porous layers of honeycomb fi lms.…”

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confidence: 87%

“…[ 11,12 ] For instance, superhydrophobic property is highly desirable when honeycomb fi lms are employed as hydrophobic and lipophobic materials such as self-cleaning surface, [ 8 ] whereas applications in the fi eld of biology, such as cell-based biosensor technologies, microfl uidic cell screening systems, tissue engineering, call for well-ordered hexagonal porous arrays with hydrophilic character since the interaction between surface and cells can be enhanced by the increased hydrophilicity. [ 1,13,14 ] Accordingly, if the surface wettability of honeycomb fi lms can be reversibly changed by external stimuli, the fi lms will have much wider applications, ranging from hydrophilic to hydrophobic areas. Furthermore, simply employing triggers to regulate surface wettability of honeycomb fi lms will replace cumbersome work Adv.…”

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confidence: 99%

“…Further increase of PDMAEMA units will greatly raise molecular hydrophilicity and hydrophilic volume. In some cases, the enhanced hydrophilicity is able to uptake bigger water droplets and results in bigger pore size, [ 6,14 ] but it works in an opposite way in this case. Since fi ve PDMAEMA units versus 220 PS units already provides suffi cient hydrophilicity for the stabilization of water droplets, and if PDMAEMA units further increase, more surface area of water droplets is required to attract extra PDMAEMA segments; otherwise, the droplets will be forced to aggregate by the increased hydrophilic volume.…”

mentioning

confidence: 99%

“…In earlier studies, [ 1,3,[12][13][14]32,33 ] honeycomb-patterned porous fi lms have been proven to be excellent candidates as scaffolds for cell culture applications owing to their greatly enlarged surface area and regular pores with narrow size distribution, which are favorable for cell attachment and spreading. However, only hydrophilic surface is suitable for cell adhesion and growth as most of the cells cannot attach on hydrophobic surface.…”

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confidence: 99%

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CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

Yin

Bulteau

Feng

et al. 2016

Adv Materials Inter

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of developing different polymers to fabricate honeycomb fi lms with different surface wettability. The reversible control of wettability enables fi lms to be recycled and reused, as a result, the production cost will be largely reduced. Moreover, adjustable wettability of interfacial materials has versatile potentials in many applications, such as controlled drug delivery, cells capture and release, and oil/water separation, in which wettability acts as a switch. [ 15 ] Therefore, development of honeycomb fi lms with tunable and reversible surface wettability is of great importance for both fundamental research and practical applications.Wettability is largely dependent on surface structure and chemical composition of the materials. [ 13,16,17 ] Generally, honeycomb fi lm surface exhibits hydrophobic characteristics derived from the hydrophobic polymer and the presence of micron-sized holes which is similar to the "lotus-effect" of plant leaves. [ 13,18 ] Considering the special morphology of honeycomb fi lms, introduction of stimuli-responsive groups on fi lm surface makes it an appropriate way to realize the adjustment of surface wettability since the reversible physical properties change can be easily achieved upon exposure to external stimulation. Hence, two approaches have been developed to introduce sensitive groups on honeycomb fi lm surface. One is based on the strategy of posttreatment on an as-prepared fi lm. [ 1,5,13 ] That is, to prepare a normal honeycomb fi lm fi rst and then stimuli-responsive moieties are introduced by further surface modifi cation. For example, Stenzel and co-workers prepared the fi rst example of thermoresponsive honeycomb structured porous polymer fi lm by grafting poly( N -isopropylacrylamide) (PNIPAAm) onto a honeycomb fi lm via reversible additionfragmentation transfer polymerization. [ 13 ] The modifi ed fi lm surface changes from hydrophobic to hydrophilic when temperature declines from 45 to 25 °C. However, postmodifi cation on honeycomb fi lm is, in fact, rather complicated, usually including several steps. In contrast, the strategy that directly employs stimuli-responsive polymer to fabricate honeycomb fi lm with smart surface is more preferred due to its simplicity and effi ciency. [ 16,17,19,20 ] In this case, the hydrophilic sensitive groups concentrate on the inner surfaces of the pores or further form nanophase structures inside the walls of the honeycomb fi lms, thereby conferring the fi lms tunable surfaces wettability. [ 16,19 ] For instance, Hu and co-workers reported the fi rst pH-responsive honeycomb fi lm by polystyrene-b -polyacrylic acid (PS-b -PAA) self-assembly. [ 17 ] The water contact angle (CA) of the original fi lm with 1.5 µm pore diameter is 96°, while it increases to 120° after the treatment with an acid aqueous solution (pH 4.0), it sharply decreases to 10° after the treatment of a base aqueous solution (pH 10.0), ascribing to the protonation of carboxylic acid groups that leads to an increase of hydrophilicity. Later, Billon and co-workers [ 19...

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confidence: 87%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

Yin

Bulteau

Feng

et al. 2016

Adv Materials Inter

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“…[ 40 ] By controlling these variables, the quality, pore size, pore size distribution, and pattern regularity can be fi nely tuned and optimized. The mean pore size usually shows a monotonic correlation with concentration [ 71,72 ] and humidity. [ 73,74 ] At the same time, the regularity of the pattern will also be affected.…”

Section: Infl Uence Of C a And Rh On The Surface Morphologymentioning

confidence: 99%

Fabrication of Durable Honeycomb‐Patterned Films of Poly(ether sulfone)s via Breath Figures

Liu

Tian

et al. 2014

Macro Chemistry & Physics

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Honeycomb-patterned porous fi lms of poly(ether sulfone) (PES) are prepared via breath fi gures (BF), in which dichloromethane (DCM) is used as the solvent, although the solubility of PES in DCM is relatively low. It is found that the use of a DCM suspension of PES as the casting solution and the addition of an amphiphilic block copolymer, poly(styrene-co -maleic acid) partial isobutyl ester (PSME), assist the stabilization of water-droplet arrays during the BF process, contributing to improved pattern regularity, and fi nally leading to the formation of highly ordered honeycomb-patterned fi lms of PES. A synergetic effect of concentration and humidity on the fi lm morphology is discovered and systematically investigated. Moreover, the resultant fi lms possess enhanced resistance to strong acid and base solutions under heating, indicating their promising applications under harsh conditions. and induces water droplets with equal diameter to condense from the humid air and eventually arrange into a honeycomb pattern. Thus, a fi lm with regular honeycomb pores can be obtained after the complete evaporation of solvent and water droplets. Recently, reported BF processes help achieve membranes and microsieves with perforated-pores and highly effi cient separation behaviors by applying special substrates [ 9 ] or pumping out excess casting solution. [ 12 ] Taking advantage of the self-assembly behavior in the BF process or post surface modifi cation, micro-patterning of proteins, [13][14][15] quantum dots, [ 16 ] nanoparticles, [ 16 ] graphene, [ 17 ] and metal oxides [ 18 ] was realized to generate advanced functional fi lms. As a replica template, the honeycomb fi lm also allows for easy transfer of its special morphology to other materials. [19][20][21] Accompanied by these remarkable progresses, the honeycomb pattern prepared by the BF strategy is strongly desired to have excellent long-term durability for extending the use of fi lms in practical applications with less limitation.The stability of honeycomb-patterned fi lms in harsh environments such as elevated temperature and acid/ base solutions is a crucial issue that has to be addressed effi ciently, so that the fi lms will remain in satisfactory

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Beyond State of the Art Honeycomb Membranes: High Performance Ordered Arrays from Multiprogrammable Linear‐Dendritic Block Copolymers

Mongkhontreerat

Walter

Andrén

et al. 2015

Adv Funct Materials

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A new generation of honeycomb membranes is herein described from a novel library of multipurpose linear-dendritic block copolymers. These are accomplished by combining atom transfer radical polymerization together with dendrimer chemistry and click reactions. The resulted amorphous block copolymers, with T g between 30 and 40 °C, display three important functions, i.e., pore generating aromatic groups, crosslinking azides, and multiple dendritic functional groups. All block copolymers enable the successful fabrication of honeycomb membranes through the facile breath fi gure method. The peripheral dendritic functionality is found to infl uence the porous morphologies from closed pored structure with pore size of 1.12 µm 2 to open pore structure with pore size 10.26 µm 2 . Facile UV crosslinking of the azides yields membranes with highly durable structural integrity. Upon crosslinking, the pH and thermal stability are extended beyond the noncrosslinked membranes in which the porous integrity is maintained up to 400 °C and pH 1-14. Taking into account the straightforward and cost-effi cient strategy to generate ordered, functional, and structurally stable honeycomb membranes on various solid substrates, it is apparent that these multipurpose block copolymers may unlock future applications including use as molds for soft lithography.

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Honeycomb-Structured Films by Multifunctional Amphiphilic Biodegradable Copolymers: Surface Morphology Control and Biomedical Application as Scaffolds for Cell Growth

Cited by 73 publications

References 68 publications

CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

Fabrication of Durable Honeycomb‐Patterned Films of Poly(ether sulfone)s via Breath Figures

Beyond State of the Art Honeycomb Membranes: High Performance Ordered Arrays from Multiprogrammable Linear‐Dendritic Block Copolymers

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Honeycomb-Structured Films by Multifunctional Amphiphilic Biodegradable Copolymers: Surface Morphology Control and Biomedical Application as Scaffolds for Cell Growth

Cited by 73 publications

References 68 publications

CO2‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

CO2‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

Fabrication of Durable Honeycomb‐Patterned Films of Poly(ether sulfone)s via Breath Figures

Beyond State of the Art Honeycomb Membranes: High Performance Ordered Arrays from Multiprogrammable Linear‐Dendritic Block Copolymers

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CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion

CO₂‐Induced Tunable and Reversible Surface Wettability of Honeycomb Structured Porous Films for Cell Adhesion