Honey for wound care in the 21st century

Cooper, Rose

doi:10.12968/jowc.2016.25.9.544

Cited by 29 publications

(35 citation statements)

References 102 publications

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“…The literature includes reports on numerous honeys, from different floral sources, for in vitro antimicrobial activity in particular. Due to the pioneering work of the late Peter Molan 3 in New Zealand over the past 25 years, it has emerged that of the range of honeys tested, those from one source, manuka, has particularly high antimicrobial activity. 4 Subsequently many other reports have supported and clarified this activity this is summarised in a review by Carter et al 5 It is owing to a series of seminal articles by Molan 6 and colleagues 7,8 in 1999 that the modern approach to honey in wound can be traced.…”

Section: Biological Research Into Honeymentioning

confidence: 99%

“…13,26 This aspect of manuka action has recently been examined using 83 clinical isolates of six genera of wound pathogens. 3,27 The study involved measurement of both minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) and electron microscopy for evidence of cell lysis. The authors concluded that 'the findings provide optimism that topical manuka honey might have a role to play in limiting multidrug resistant Gram-negative bacteria'.…”

Section: Antimicrobial Actionmentioning

confidence: 99%

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Manuka honey in wound management: greater than the sum of its parts?

White

2016

J Wound Care

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Few involved in wound care will have escaped the considerable interest which has been generated by the resurgence in honey. Equally, there will be many clinicians around the globe who are wondering why all the fuss, as they will have been using honey all along. However, even with the advent of 'medical-grade' honey, combined with considerable research into the numerous potential modes of action, there remains a lingering scepticism regarding the value of honey as a justified, modern intervention in wound care. The purpose of this brief review is to summarise the ongoing chemical, biochemical and microbiological research and to correlate it with clinical outcomes. The purpose being to present the enquiring clinician with an evidence summary with which clinical choices may be made. While much of the early research was into generic honeys, one particular source, manuka, appears especially effective, and as such this has been the focus of recent studies.

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Section: Biological Research Into Honeymentioning

confidence: 99%

Section: Antimicrobial Actionmentioning

confidence: 99%

Manuka honey in wound management: greater than the sum of its parts?

White

2016

J Wound Care

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“…The chemical composition of honey makes it a complex natural mixture of chemical compounds allowing it to show important biological properties, such as the ability to promote wound healing [ 2 ] and its antimicrobial, anti-inflammatory, and antioxidant capacity [ 3 ]. The antioxidant and antimicrobial capacity of honey has been one of the biological properties most studied in honey and has been closely associated with its floral origin [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Botanical Origin and Chemical Composition on the Protective Effect against Oxidative Damage and the Capacity to Reduce In Vitro Bacterial Biofilms of Monofloral Honeys from the Andean Region of Ecuador

García-Tenesaca

Navarrete

Iturralde

et al. 2017

IJMS

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Three types of monofloral honey from the Andean regions of Ecuador (Avocado, Eucalyptus, and Rapeseed honey) were analyzed to determine their floral origin, physicochemical parameters, chemical composition, antioxidant capacity, and their capacity to reduce in vitro bacterial biofilms. The chemical composition varied considerably depending on floral origin. The highest values of bioactive compounds were found in Avocado honey, classified as dark amber in color, while the lowest values were found in Eucalyptus honey followed by Rapeseed honey, both classified as extra light amber. When compared to Eucalyptus and Rapeseed honey, Avocado honey showed a more effective superoxide scavenging activity, chelating metal ions capacity, and a higher ability to protect human erythrocyte membranes against lipid peroxidation. For antimicrobial activity, the hydrogen peroxide content and the capacity to inhibit the biofilm formation, and to remove preformed biofilm from Staphylococcus aureus and Klebsiella pneumoniae was determined. Avocado honey showed the highest values of hydrogen peroxide content, as well as the highest capacity to reduce in vitro bacterial biofilms. A correlation between color vs. phenolics content vs. superoxide scavenging activity vs. chelating metal ions capacity, and the capacity to protect human erythrocyte membranes against lipid peroxidation was found.

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“…The development of wound care products including honey is continuing rapidly. It is used in wound dressings or in tube form for wound treatments [7,8]. Manuka honey is scientifically recognized for its antimicrobial and wound healing properties and is now used in topical treatment of wound infections in clinics [17].…”

Section: Groupmentioning

confidence: 99%

“…Honey has antibacterial effect and many other therapeutic properties supporting healing [4,7,8]. Honey creates a cleansing effect on the wound and debride the necrotic tissue.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Manuka Honey (Manuka Nd, G) and Etacridine Lactate (Rivanol) Applications in the Treatment of Infected Wounds in Cats

Kemiksiz

Akçay

2019

Acta Scientiae. Vet.

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Background: Ethacridine lactate (Rivanol) has been used as an antibacterial drug in the treatment of infected wounds for many years. Although Manuka honey has been used in the treatment of burns, ulcers and infected wounds in human medicine for many years, its use in veterinary medicine is new. Manuka honey has been found to provide rapid cicatrization and lower chronic pain levels, to prevent bad odor, and has antibacterial properties. The aim of this study was to compare the effects of Etacridine lactate and Manuka honey in the treatment of infected wounds in cats.Materials, Methods & Results: In this study, 32 cats, with infected wounds in different areas on their body, were used. Cats were divided into two groups. The Rivanol group (n = 16) consisted of 6 female and 10 male cats aged 4 ± 3 years from different breeds and in several weights. Manuka group (n = 16) consisted of 7 male and 9 female cats of different breeds and weight and aged 4 ± 2 years. Rivanol was applied to the first group and Manuka honey (Manuka Nd, G) was applied to the second group. First measurements were recorded after the surgical debridement of the wound area. Four measurements were made every 3 days. The size (length - width) of the wounds was measured and recorded. Parenteral Marbofloxacin was administered orally in all cases. In order to prevent the contact of the cases with the dressing, the collar was worn. In the Rivanol group, when the first measurement values (length: 4.29 ± 2.78 cm, width: 2.13 ± 0.58 cm) and the 4th measurement values (length: 2.21 ± 1.37 cm, width: 1.06 ± 0.41 cm) were compared, there was a decrease in the wound size. In the Manuka group, when the first measurement values (length 2.84 ± 1.51 cm, width: 2.01 ± 1.03cm) and the 4th measurement values (length: 1.42 ± 1.10 cm, width: 0.90 ± 0.72cm) were compared, the wound sizes were diminished as in the Rivanol group. In all measurement days, the differences between of Rivanol and Manuka groups concerning the width, length and wound sizes were not statistically significant (P > 0.05). Wound size, length and width showed a linear decrease over the measurement days. These decreases were similar in Rivanol and Manuka group. There was no statistically significant difference between Rivanol (12.44 ± 3.74 days) and Manuka (12.44 ± 4.68 days) groups over the cicatrization period (P > 0.05).Discussion: Rivanol and Manuka honey were effective in wound healing. Although there were no differences between the two groups, the wound sizes decreased in each measurement of the wounds. A moist environment was formed on the wound, debrideman accelerated and granulation tissue formation was encouraged with the application of both topical agents. Therefore, it was considered that wound healing in our cases was successful. It has been found that honey is frequently applied in wound treatment and in many areas in human medicine. However, in the field of veterinary medicine, there were few investigations. In the treatment of infected wounds of cats, it was determined that the application of Rivanol and Manuka honey yielded similar results in terms of time and there was no statistically significant difference. Manuka honey was found to be an alternative to Rivanol in the treatment of infected cat wounds. Manuka honey preparations (pad or pomade) were preferred because of the ease of use. In order to determine the efficacy of manuka honey in wound healing, it was thought that many further clinical or experimental studies should be carried out using microbiological, biochemical and histopathological parameters.

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Honey for wound care in the 21st century

Cited by 29 publications

References 102 publications

Manuka honey in wound management: greater than the sum of its parts?

Manuka honey in wound management: greater than the sum of its parts?

Influence of Botanical Origin and Chemical Composition on the Protective Effect against Oxidative Damage and the Capacity to Reduce In Vitro Bacterial Biofilms of Monofloral Honeys from the Andean Region of Ecuador

Comparison of Manuka Honey (Manuka Nd, G) and Etacridine Lactate (Rivanol) Applications in the Treatment of Infected Wounds in Cats

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