Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation

Hamad, Rania T.; Jayakumar, Calpurnia; Ranganathan, Punithavathi; Mohamed, Riyaz; El-Hamamy, Mahmoud Mohamed Ismail; Dessouki, Amina; Ibrahim, Abdelazim; Ramesh, Ganesan

doi:10.1111/1440-1681.12433

Cited by 47 publications

(22 citation statements)

References 25 publications

(34 reference statements)

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“…In addition, it was demonstrated that honey collected in the United Arab Emirates can protect liver and kidney during acute blood loss, food restriction, and after carbon tetrachloride intoxication [ 10 - 14 ]. Other studies found that honey from different regions showed a protective effect in cisplatin, carbon tetrachloride, and cyclophosphamide-induced kidney toxicity [ 15 - 17 ]. Honey treatment improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels and improved the morphology of the kidney cells of the melamine-fed rats [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats

Imtara¹,

Al-Waili²,

Bakour³

et al. 2018

Vet World

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Aim:The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide.Materials and Methods:Honey was collected in Tulkarm, Palestine, and its phenol, flavones, and flavonol content were assessed. The antioxidant activity was determined with the use of colorimetric assays, 1,1-diphenyl-2-picrylhydrazyl, ferric reducing antioxidant power, and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid). Two sets of experiments were conducted. First experiment: 18 rats were used for the evaluation of diuretic activity of honey. The rats received either honey or furosemide. Renal function test, uric acid, and serum and urine electrolytes assay were performed. Second experiment: 18 male mice were used to evaluate the wound healing property of honey. Wounds were created on mice skin and treated daily with honey or Madecassol. Measurements of wounds were performed over a period of 12 days.Results:The physical and chemical parameters of Tulkarm honey are within the limits of the European legislation and fulfilling the criteria described in the standard codex for honey. It contains antioxidant compounds and shows antioxidant activity. Oral honey increased creatinine clearance and urine volume, sodium, and chloride without causing hypokalemia or affecting blood urea, uric acid, or serum creatinine level. The diuretic activity of furosemide was associated with hypokalemia. Topical honey application enhanced wound closure when compared with the Madecassol application.Conclusion:The study is the first to report that honey collected from Tulkarm has a considerable diuretic effect without affecting serum electrolytes or kidney function test and exhibits strong antioxidant activity and wound healing property.

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Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats

Imtara¹,

Al-Waili²,

Bakour³

et al. 2018

Vet World

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“…Although the exact mechanism responsible for cisplatin-induced nephrotoxicity is not fully understood, there is growing evidence that multiple cellular and molecular mechanisms were found to be involved [ 3 ]. The generation of reactive oxygen species (ROS) and decrease of antioxidant enzymes was found to be involved [ 4 , 5 ]. Excessive ROS generation caused by cisplatin may lead to lipid peroxidation (LPO) and delayed-onset kidney injury.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis

et al. 2016

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Although cisplatin is an effective anti-cancer agent that is widely used for treating various types of malignant solid tumors, the nephrotoxicity induced by cisplatin severely limits its clinical application. The present study was designed to explore the potential protective effect of ginsenoside Rg5, a rare ginsenoside generated during steaming ginseng, on cisplatin-induced nephrotoxicity in a mouse experimental model. The possible mechanisms underlying this nephroprotective effect were also investigated for the first time. Rg5 was given at doses of 10 and 20 mg/kg for 10 consecutive days. On Day 7, a single nephrotoxic dose of cisplatin (25 mg/kg) was injected to mice. Cisplatin administration resulted in renal dysfunction as evidenced by increase in serum creatinine (CRE) and blood urea nitrogen (BUN) levels. In addition, cisplatin increased the level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), the makers of lipid peroxidation, and depleted glutathione (GSH) content and superoxide dismutase (SOD) activity in renal tissues. These effects were associated with the significantly increased levels of cytochrome P450 E1 (CYP2E1), 4-hydroxynonenal (4-HNE), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, nuclear factor-kappa B (NF-κB) p65, and cyclooxygenase-2 (COX-2) in renal tissues. However, pretreatment with ginsenoside Rg5 significantly attenuated the renal dysfunction, oxidative stress and inflammation response induced by cisplatin. Furthermore, ginsenoside Rg5 supplementation inhibited activation of apoptotic pathways through increasing Bcl-2 and decreasing Bax expression levels. Histopathological examination further confirmed the nephroprotective effect of Rg5. Collectively, these results clearly suggest that Rg5-mediated alleviation of cisplatin-induced nephrotoxicity may be related to its anti-oxidant, anti-apoptotic and anti-inflammatory effects.

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“…10,16 It has been reported that inhibition of NFκB signaling has protective effects on cisplatin nephropathy. [20][21][22][23][24] Our data indicated that DS-5272 inhibits NFκB signaling, which contributes to amelioration of cisplatin nephropathy in vivo and decreased cell injury in vitro. In this study, however, there were two major discrepancies between the time course of MDM2 expression and the effect of DS-5272.…”

Section: Discussionmentioning

confidence: 65%

MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition

Fujikura

Yasuda

Iwakura

et al. 2018

Pharmacology Res & Perspec

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Cisplatin is a platinum‐containing chemotherapeutic drug, which is widely used and highly effective. While effective against tumors, its use is limited by severe side effects such as nephrotoxicity and bone marrow suppression. Murine double minute 2 (MDM2) is the E3 ubiquitin ligase of the tumor suppressor gene, p53, and inhibition of MDM2 can suppress tumor cell growth. However, independent of p53, MDM2 acts as a co‐transcription factor for nuclear factor‐κB (NFκB), whose signaling can be involved in cisplatin‐induced tubular injury. We therefore examined the effects of MDM2 inhibitor on cisplatin cytotoxicity. In order to induce acute kidney injury and to investigate MDM2 inhibitory effects, we injected cisplatin into rats with or without the MDM2 inhibitor, DS‐5272, and analyzed kidney physiology/histology and NFκB signaling. Serum creatinine was significantly lower in the DS‐5272 group than in the vehicle group on day 3 (0.55 ± 0.069 vs 0.70 ± 0.072 mg/dL, P < 0.05). DS‐5272 also significantly decreased kidney injury molecule‐1 (KIM‐1) expression, improved tubular injury, and decreased apoptotic cells. Western blotting showed that cisplatin increased NFκB phosphorylation in kidneys, which was significantly suppressed by DS‐5272. In vitro, we treated HEK 293 cells with cisplatin, in the absence or presence of DS‐5272, and examined cytotoxicity and NFκB transcriptional activity. DS‐5272 co‐treatment reduced both cisplatin‐induced cell death and NFκB transcriptional activity. Collectively, these findings suggest that DS‐5272 can ameliorate cisplatin nephrotoxicity via NFκB signal inhibition.

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Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation

Cited by 47 publications

References 25 publications

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats

Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis

MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition

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