Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial

Awad, Osama G. Abdel-Naby; Hamad, Abdel-Monem H.

doi:10.1016/j.amjoto.2018.09.007

Cited by 25 publications

(7 citation statements)

References 18 publications

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“…In a clinical trial of 100 children aged 2–8, the group receiving a combination of honey and oral acyclovir had significantly earlier disappearance of herpes simplex gingivostomatitis than those receiving acyclovir alone. The treatment group also had significantly lower pain scores, better eating and drinking ability, and less analgesic need than the control group 26 . These studies confirm that honey is a potent antiherpetic agent and should be considered in a treatment regimen for lesions caused by the herpes virus.…”

Section: Human Herpesvirus Types 1 Andsupporting

confidence: 56%

“…The treatment group also had significantly lower pain scores, better eating and drinking ability, and less analgesic need than the control group. 26 These studies confirm that honey is a potent antiherpetic agent and should be considered in a treatment regimen for lesions caused by the herpes virus. psoriasis vulgaris improved with psoriasis area and severity index score to 80 1 month after finishing the honey treatment.…”

Section: Human Herpesvirus Types 1 Andmentioning

confidence: 55%

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Honey therapies for dermatological disorders: more than just a sweet elixir

Jodidio,

Schwartz

2023

Int J Dermatology

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Honey possesses antibacterial, anti‐inflammatory, and healing properties that benefit wound healing and tissue regeneration. For centuries, honey has been utilized in traditional medicine as a binder or vehicle for creams and lotions and also for therapeutic purposes. The overuse of antibiotics and antimicrobial agents leading to drug resistance has emphasized the resurgence of honey's application in wound care. For many dermatological disorders, there is an interest in developing therapeutics with fewer side effects than traditional therapies and enhanced wound healing abilities to expedite tissue regeneration. This paper reviews the properties and components of honey that contribute to its wound‐healing‐based applications, the types of honey employed in medicine, and its dermatological applications. Based on the evidence from case reports, clinical trials, and in vitro studies, honey has been characterized as a safe, cost‐effective, and readily available treatment option for many skin conditions, including microbial infections, atopic dermatitis, psoriasis, necrotizing fasciitis, ulcers, as well as thermal and other types of wounds.

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Section: Human Herpesvirus Types 1 Andsupporting

confidence: 56%

Section: Human Herpesvirus Types 1 Andmentioning

confidence: 55%

Honey therapies for dermatological disorders: more than just a sweet elixir

Jodidio,

Schwartz

2023

Int J Dermatology

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“…The third trial, a randomized double-blind placebo-controlled study examined the combined efficacy of commercially or locally (Egypt) available honey with acyclovir suspension compared to acyclovir alone in one hundred children aged 2-8 years. The combination of honey with acyclovir led to faster disappearance of the lesion (3 days vs. 6 days), fewer eating difficulties, and lower pain scores (all significant) [50].…”

Section: Discussionmentioning

confidence: 85%

Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores—A Clinical Study

et al. 2021

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Cold sores are nasolabial blisters caused by herpes simplex virus (HSV) infections. Novel therapies demonstrating simultaneously antiviral activity and improved wound healing are warranted. The aim of this study was to investigate the efficacy of medical-grade honey (MGH) for treating HSV-induced cold sores. A crossover trial was performed in patients with recurrent cold sores (n = 29). The majority (65.6%) of these patients experience four or more episodes per year, thus forming a valid self-control group. In this study, patients applied an MGH-based formulation (L-Mesitran Soft) on their cold sore at the onset of symptoms (62.1%) or appearing of blister (37.9%) and compared it to their conventional treatments. After complete healing, patients filled in a questionnaire evaluating healing, pain, and itching. The average absolute healing time was 72.4% slower with conventional treatment (10.0 days) compared to MGH (5.8 days). After MGH treatment, 86.2% of all patients experienced faster objective healing (6.9% similar and 6.9% slower) and the subjective healing score was higher in 79.3% of the patients (20.7% similar). If the patients normally experience pain and itching during their cold sores, these levels were lower with MGH therapy compared to conventional treatment in 72.7% and 71.4% of the patients, respectively. Moreover, 100% of the patients prefer MGH treatment over conventional treatment and will use it again on future cold sores. MGH is a promising alternative treatment for cold sores, likely by combining both increased antiviral and wound healing activities while alleviating pain and itching.

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“…In fact, honey can modulate the molecular targets involved in cellular signaling pathways, such as apoptosis and inflammation, as well as signaling cascades needed for virus replication and attachment to the host cells [103,104]. Varicella zoster [105], rubella [106], influenza [107], herpes simplex [108], respiratory syncytial virus [109], immunodeficiency virus [110], viral hepatitis A [110], are among the pathogens effectively inhibited by honey.…”

Section: Honey As a Co-adjuvant Of Sars-cov-2 Infection Treatmentmentioning

confidence: 99%

Honey as an Adjuvant in the Treatment of COVID-19 Infection: A Review

et al. 2022

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Since ancestor times, honey has been used to promote human health due to its medicinal, and nutritious properties, mainly due to bioactive compounds present, such as phenolic compounds. The emergence of COVID-19, caused by the SARS-CoV-2 virus, led to the pursuit of solutions for the treatment of symptoms and/or disease. Honey has proven to be effective against viral infections, principally due to its potential antioxidant and anti-inflammatory activities that attenuate oxidative damage induced by pathogens, and by improving the immune system. Therefore, the aim of this review is to overview the abilities of honey to attenuate different COVID-19 symptoms, highlighting the mechanisms associated with these actions and relating the with the different bioactive compounds present. A brief, detailed approach to SARS-CoV-2 mechanism of action is first overviewed to allow readers a deep understanding. Additionally, the compounds and beneficial properties of honey, and its previously application in other similar diseases, are detailed in depth. Despite the already reported efficacy of honey against different viruses and their complications, further studies are urgently needed to explain the molecular mechanisms of activity against COVID-19 and, most importantly, clinical trials enrolling COVID-19 patients.

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Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial

Cited by 25 publications

References 18 publications

Honey therapies for dermatological disorders: more than just a sweet elixir

Honey therapies for dermatological disorders: more than just a sweet elixir

Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores—A Clinical Study

Honey as an Adjuvant in the Treatment of COVID-19 Infection: A Review

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