Honey bee Apis mellifera larvae gut microbial and immune, detoxication responses towards flumethrin stress

Yu, Longtao; Yang, Heyan; Cheng, Fu-Ping; Wu, Zhihao; Huang, Qiang; He, Xingjian; Wei, Yan; Zhang, Lizhen; Wu, Xiaobo

doi:10.1016/j.envpol.2021.118107

Cited by 27 publications

(13 citation statements)

References 49 publications

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“…This finding supported the hypothesis that Wolbachia increases host resistance to imidacloprid by increasing the expression of the gene encoding the enzyme responsible for its metabolism, NlCYP4CE1 ( Cai et al, 2021 ). The gut microbiome of pollinators like the honeybee ( Apis mellifera ) increases tolerance to pesticides like thiacloprid, tau-fluvalinate, and flumethrin by promoting the expression of genes involved in immunity and detoxification ( Wu et al, 2020 ; Yu et al, 2021 ). When creating novel pest control methods or reducing pests’ vector competence, it is important to keep an eye on the role of the pests’ microbial partners.…”

Section: Resistance In Invasive Insectsmentioning

confidence: 99%

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

et al. 2023

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Threatening the global community is a wide variety of potential threats, most notably invasive pest species. Invasive pest species are non-native organisms that humans have either accidentally or intentionally spread to new regions. One of the most effective and first lines of control strategies for controlling pests is the application of insecticides. These toxic chemicals are employed to get rid of pests, but they pose great risks to people, animals, and plants. Pesticides are heavily used in managing invasive pests in the current era. Due to the overuse of synthetic chemicals, numerous invasive species have already developed resistance. The resistance development is the main reason for the failure to manage the invasive species. Developing pesticide resistance management techniques necessitates a thorough understanding of the mechanisms through which insects acquire insecticide resistance. Insects use a variety of behavioral, biochemical, physiological, genetic, and metabolic methods to deal with toxic chemicals, which can lead to resistance through continuous overexpression of detoxifying enzymes. An overabundance of enzymes causes metabolic resistance, detoxifying pesticides and rendering them ineffective against pests. A key factor in the development of metabolic resistance is the amplification of certain metabolic enzymes, specifically esterases, Glutathione S-transferase, Cytochromes p450 monooxygenase, and hydrolyses. Additionally, insect guts offer unique habitats for microbial colonization, and gut bacteria may serve their hosts a variety of useful services. Most importantly, the detoxification of insecticides leads to resistance development. The complete knowledge of invasive pest species and their mechanisms of resistance development could be very helpful in coping with the challenges and effectively developing effective strategies for the control of invasive species. Integrated Pest Management is particularly effective at lowering the risk of chemical and environmental contaminants and the resulting health issues, and it may also offer the most effective ways to control insect pests.

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Section: Resistance In Invasive Insectsmentioning

confidence: 99%

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

et al. 2023

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“…This result suggested that Wolbachia enhances the resistance of hosts to imidacloprid by promoting the expression of NlCYP4CE1 [ 88 ]. For pollinators such as the honeybee ( Apis mellifera ), the gut microbiota promotes the expression of some immune-related genes (hymenoptaecin, defensin1) and detoxification-related genes ( CYP450s , GST, and catalase ), and thus increase honeybee tolerance to thiacloprid, tau-fluvalinate, or flumethrin [ 89 , 90 ].…”

Section: Association Between Gut Bacteria and Insects’ Adaptation To ...mentioning

confidence: 99%

The Role of Insect Symbiotic Bacteria in Metabolizing Phytochemicals and Agrochemicals

Zhao

Lin

Guo

2022

Insects

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The diversity and high adaptability of insects are heavily associated with their symbiotic microbes, which include bacteria, fungi, viruses, protozoa, and archaea. These microbes play important roles in many aspects of the biology and physiology of insects, such as helping the host insects with food digestion, nutrition absorption, strengthening immunity and confronting plant defenses. To maintain normal development and population reproduction, herbivorous insects have developed strategies to detoxify the substances to which they may be exposed in the living habitat, such as the detoxifying enzymes carboxylesterase, glutathione-S-transferases (GSTs), and cytochrome P450 monooxygenases (CYP450s). Additionally, insect symbiotic bacteria can act as an important factor to modulate the adaptability of insects to the exposed detrimental substances. This review summarizes the current research progress on the role of insect symbiotic bacteria in metabolizing phytochemicals and agrochemicals (insecticides and herbicides). Given the importance of insect microbiota, more functional symbiotic bacteria that modulate the adaptability of insects to the detrimental substances to which they are exposed should be identified, and the underlying mechanisms should also be further studied, facilitating the development of microbial-resource-based pest control approaches or protective methods for beneficial insects.

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“…For instance, exposure to sublethal doses of thiacloprid significantly aggravated the proliferation of black queen cell virus (BQCV) on host larval and boost the harmful effects of the virus on honey bees ( Doublet et al, 2015 ). Sublethal pesticide exposure in honey bees larvae can cause oxidative stress by increasing the levels of reactive oxygen species (ROS) in the bees’ bodies, which can cause damage to cellular components such as DNA, proteins, and lipids ( Prezenska et al, 2019 ; Yu et al, 2021 ). The GST (glutathione S-transferase) gene family encodes enzymes that participates in the process of ROS removal by interaction with glutathione ( Schultzhaus et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Exposure of chlorothalonil and acetamiprid reduce the survival and cause multiple internal disturbances in Apis mellifera larvae reared in vitro

Lü

Gao²,

Wu³

et al. 2023

Front. Physiol.

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Background: Chlorothalonil and acetamiprid are chemical pesticides commonly used in agricultural production and have been shown to have negative effects on bee’s fitness. Despite many studies have revealed that honey bee (Apis mellifera L.) larvae are posting a high risk on exposure to pesticides, but the toxicology information of chlorothalonil and acetamiprid on bee larvae remain limited.Results: The no observed adverse effect concentration (NOAEC) of chlorothalonil and acetamiprid for honey bee larvae were 4 μg/mL and 2 μg/mL, respectively. Except for CarE, the enzymic activities of GST and P450 were not influenced by chlorothalonil at NOAEC, while chronic exposure to acetamiprid slightly increased the activities of the three tested enzymes at NOAEC. Further, the exposed larvae showed significantly higher expression of genes involved in a series of different toxicologically relevant process following, including caste development (Tor (GB44905), InR-2 (GB55425), Hr4 (GB47037), Ac3 (GB11637) and ILP-2 (GB10174)), immune system response (abaecin (GB18323), defensin-1 (GB19392), toll-X4 (GB50418)), and oxidative stress response (P450, GSH, GST, CarE).Conclusion: Our results suggest that the exposure to chlorothalonil and acetamiprid, even at concentrations below the NOAEC, showed potentially effects on bee larvae’s fitness, and more important synergistic and behavioral effects that can affect larvae fitness should be explored in the further.

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Honey bee Apis mellifera larvae gut microbial and immune, detoxication responses towards flumethrin stress

Cited by 27 publications

References 49 publications

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies

The Role of Insect Symbiotic Bacteria in Metabolizing Phytochemicals and Agrochemicals

Exposure of chlorothalonil and acetamiprid reduce the survival and cause multiple internal disturbances in Apis mellifera larvae reared in vitro

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